El propóleo una alternativa de todos los tiempos

Se tiene conocimiento de que el empleo del propóleo en diversas afecciones data de miles de años. Fue utilizado por los egipcios, griegos y romanos. Actualmente el propóleo ha despertado un gran interés en científicos de todo el mundo, ya que ha demostrado una potente actividad biológica, desde el punto de vista terapéutico y nutricional. En nuestro país se han comprobado sus diferentes acciones farmacológicas, tales como: acción bactericida, antiviral, anestésica local y analgésica, inmunoestimulante, antioxidante, cicatrizante y regeneradora de tejidos, anticaries dentarias, antiinflamatoria, antitrombótica, antiulceroso. Resalta el hecho de que en nuestra provincia se usa principalmente en la estomatología. Basados en este argumento se realizó una búsqueda exhaustiva del tema para mostrar las consideraciones preventivas y terapéuticas actuales del propóleo y sus propiedades ventajosas de su uso, consultando 21 fuentes de las más actuales y fiables en Cuba y el resto del mundo

Effect of remote ischaemic conditioning on clinical outcomes in patients with acute myocardial infarction (CONDI-2/ERIC-PPCI): a single-blind randomised controlled trial.

BACKGROUND: Remote ischaemic conditioning with transient ischaemia and reperfusion applied to the arm has been shown to reduce myocardial infarct size in patients with ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PPCI). We investigated whether remote ischaemic conditioning could reduce the incidence of cardiac death and hospitalisation for heart failure at 12 months. METHODS: We did an international investigator-initiated, prospective, single-blind, randomised controlled trial (CONDI-2/ERIC-PPCI) at 33 centres across the UK, Denmark, Spain, and Serbia. Patients (age >18 years) with suspected STEMI and who were eligible for PPCI were randomly allocated (1:1, stratified by centre with a permuted block method) to receive standard treatment (including a sham simulated remote ischaemic conditioning intervention at UK sites only) or remote ischaemic conditioning treatment (intermittent ischaemia and reperfusion applied to the arm through four cycles of 5-min inflation and 5-min deflation of an automated cuff device) before PPCI. Investigators responsible for data collection and outcome assessment were masked to treatment allocation. The primary combined endpoint was cardiac death or hospitalisation for heart failure at 12 months in the intention-to-treat population. This trial is registered with ClinicalTrials.gov (NCT02342522) and is completed. FINDINGS: Between Nov 6, 2013, and March 31, 2018, 5401 patients were randomly allocated to either the control group (n=2701) or the remote ischaemic conditioning group (n=2700). After exclusion of patients upon hospital arrival or loss to follow-up, 2569 patients in the control group and 2546 in the intervention group were included in the intention-to-treat analysis. At 12 months post-PPCI, the Kaplan-Meier-estimated frequencies of cardiac death or hospitalisation for heart failure (the primary endpoint) were 220 (8·6%) patients in the control group and 239 (9·4%) in the remote ischaemic conditioning group (hazard ratio 1·10 [95% CI 0·91-1·32], p=0·32 for intervention versus control). No important unexpected adverse events or side effects of remote ischaemic conditioning were observed. INTERPRETATION: Remote ischaemic conditioning does not improve clinical outcomes (cardiac death or hospitalisation for heart failure) at 12 months in patients with STEMI undergoing PPCI. FUNDING: British Heart Foundation, University College London Hospitals/University College London Biomedical Research Centre, Danish Innovation Foundation, Novo Nordisk Foundation, TrygFonden

Señales aterogénicas tempranas en un área de salud del municipio Consolación del Sur

Introduction: The World Health Organization has acknowledged that atherosclerosis is the most worrisome epidemic in the world due to its functional consequences.Objective: To identify early atherogenic signs in children between 5 and 11 years of age who belong to an urban health area. Method: An observational descriptive cross-sectional study was conducted. The universe consisted of 470 children, between 5 and 11 years of age, who receive primary health care in the Villa 1 People's Council of the 27 de Noviembre Polyclinic in Consolación del Sur, Pinar del Rio, Cuba. The sample was selected using the simple random method, and consisted of 148 children whose parents gave informed consent for their participation in the study. Sociodemographic, anthropometric and other variables of interest were studied, including blood pressure, birth weight, and a family history of hypertension and diabetes mellitus. Results: 58.1% of the schoolchildren in the study were male; 15 subjects (10.1%) had low birth weight and 22 (14.9%) were obese. A total of 15 schoolchildren (10.1%) were identified as hypertensives. Conclusions: There was a predominance of males, where anthropometric values were slightly elevated compared to females. Overweight, obesity, a family history of disease and hypertension were identified as the most common atherosclerotic signs.Introducción: La Organización Mundial de la Salud ha reconocido que la aterosclerosis constituye la epidemia más preocupante en el mundo debido a sus consecuencias orgánicas. Objetivo: Identificar las señales aterogénicas tempranas en niños entre 5 y 11 años de edad, pertenecientes a un área de salud urbana. Método: Estudio observacional descriptivo con diseño transversal. El universo estuvo constituido por los 470 niños entre 5 y 11 años de edad que reciben atención primaria de salud en el Consejo Popular Villa 1 del Policlínico “27 de noviembre” de Consolación del Sur, en Pinar del Río, Cuba. La muestra, seleccionada por el método aleatorio simple, quedó constituida por 148 niños cuyos padres ofrecieron el consentimiento informado para participar en el estudio. Se estudiaron variables sociodemográficas, antropométricas y otras de interés: tensión arterial, peso al nacer, antecedentes patológicos familiares de hipertensión y diabetes mellitus. Resultados: El 58,1 % de los escolares estudiados fueron del sexo masculino, 15 (10,1 %) presentaron bajo peso al nacer y 22 (14,9 %), eran obesos. Se detectaron 15 escolares (10,1 %) hipertensos. Conclusiones: Predominó el sexo masculino, donde los valores antropométricos fueron ligeramente elevados con respecto al sexo femenino. Se identificaron al sobrepeso, la obesidad, los antecedentes patológicos familiares y a la hipertensión arterial como las señales ateroscleróticas más frecuentes

Memorias del primer Simposio Nacional de Ciencias Agronómicas

Primer simposio nacional de Ciencias Agronómicas: El renacer del espacio de discusión científica para el Agro colombiano

Memorias del primer Simposio Nacional de Ciencias Agronómicas

Primer simposio nacional de Ciencias Agronómicas: El renacer del espacio de discusión científica para el Agro colombiano

Revista Temas Agrarios Volumen 26; Suplemento 1 de 2021

1st International and 2nd National Symposium of Agronomic Sciences: The rebirth of the scientific discussion space for the Colombian Agro.1 Simposio Intenacional y 2 Nacional de Ciencias Agronómicas: El renacer del espacio de discusión científica para el Agro colombiano

High PEEP with recruitment maneuvers versus Low PEEP During General Anesthesia for Surgery -a Bayesian individual patient data meta-analysis of three randomized clinical trials

Background: The influence of high positive end-expiratory pressure (PEEP) with recruitment maneuvers on the occurrence of postoperative pulmonary complications after surgery is still not definitively established. Bayesian analysis can help to gain further insights from the available data and provide a probabilistic framework that is easier to interpret. Our objective was to estimate the posterior probability that the use of high PEEP with recruitment maneuvers is associated with reduced postoperative pulmonary complications in patients with intermediate-to-high risk under neutral, pessimistic, and optimistic expectations regarding the treatment effect. Methods: Multilevel Bayesian logistic regression analysis on individual patient data from three randomized clinical trials carried out on surgical patients at Intermediate-to-High Risk for postoperative pulmonary complications. The main outcome was the occurrence of postoperative pulmonary complications in the early postoperative period. We studied the effect of high PEEP with recruitment maneuvers versus Low PEEP Ventilation. Priors were chosen to reflect neutral, pessimistic, and optimistic expectations of the treatment effect. Results: Using a neutral, pessimistic, or optimistic prior, the posterior mean odds ratio (OR) for High PEEP with recruitment maneuvers compared to Low PEEP was 0.85 (95% Credible Interval [CrI] 0.71 to 1.02), 0.87 (0.72 to 1.04), and 0.86 (0.71 to 1.02), respectively. Regardless of prior beliefs, the posterior probability of experiencing a beneficial effect exceeded 90%. Subgroup analysis indicated a more pronounced effect in patients who underwent laparoscopy (OR: 0.67 [0.50 to 0.87]) and those at high risk for PPCs (OR: 0.80 [0.53 to 1.13]). Sensitivity analysis, considering severe postoperative pulmonary complications only or applying a different heterogeneity prior, yielded consistent results. Conclusion: High PEEP with recruitment maneuvers demonstrated a moderate reduction in the probability of PPC occurrence, with a high posterior probability of benefit observed consistently across various prior beliefs, particularly among patients who underwent laparoscopy