Fibrin adhesive implant in wound healing repair of dental sockets with topical application of epsilon aminocaproic acid: Histological analysis

The aim of the study was to evaluate wound healing repair of dental sockets after topical application of 5% epsilon-aminocaproic acid (EACA) and the use of fibrin adhesive implant in rats under anticoagulant therapy with warfarin. Sixty Albinus wistar rats were used, divided into three groups of 20. In Group I, the animals were given 0.1 mL/100 mg of 0.9% saline solution per day, beginning 6 days before dental extraction and continuing throughout the experimental period. In Group II, the animals received 0.03 mL of sodium warfarin daily, beginning 6 days before the surgery and continuing until the day of sacrifice; after tooth extractions, the sockets were filled with fibrin adhesive material. In Group III the animals were treated as in Group II, and after extractions, the sockets were irrigated with 5 mL of 5% EACA and filled with the same fibrin adhesive material. All groups presented biological phases of wound healing repair, the differences being evident only in the chronology. The results obtained in Group III were very similar to those of Group I in the last period of wound repair, whereas Group II presented a late chronology compared to the other groups. © 2005 Wiley Periodicals, Inc

Antifibrinolytic Drugs (Aminocaproic Acid and Tranexamic Acid): Treatment Perspectives for Dental Surgery

The purpose of the review was to evaluate the risks and benefits of antifibrinolytic drugs, aminocaproic acid and tranexamic acid, with respect to dental surgery. The literature supports the utilization of antifibrinolytic drugs particularly with regard to hemophilia and other bleeding dyscrasias. Systemic therapy has potential risks, although blood studies allow for the safe utilization of antifibrinolytics. The use of topical antifibrinolytic drugs demonstrates benefit without significant risk