Survival and success of zirconia compared with titanium implants: a systematic review and meta-analysis.

OBJECTIVE: This systematic review assessed the available evidence on the survival and success rate of zirconia and titanium implants. As secondary outcomes, aesthetic, radiographic and clinical parameters, as well as biological and mechanical complications, were considered. MATERIALS AND METHODS: A systematic search was performed up to March 2022 to identify CCTs/RCTs comparing zirconia and titanium implants with a minimum of 12 months of follow-up. Meta-analysis was performed when ≥ 2 articles with similar characteristics were retrieved. RESULTS: Four published articles with two RCTs (2 different patient populations) with 100 zirconia and 99 titanium implants that were followed up over 12-80 months were selected out of the 6040 articles. A non-statistically significant difference between zirconia and titanium implant survival at 12 months was suggested (P = 0.0938). The success rates were 57.5-93.3% and 57.1-100% for zirconia and titanium implants, respectively. The pink aesthetic score (PES) was higher for zirconia (10.33 ± 2.06 to 11.38 ± 0.92) compared to titanium implants (8.14 ± 3.58 to 11.56 ± 1.0). CONCLUSION: Based on the 2 RCTs retrieved in the literature, similar survival rates were reported for zirconia and titanium implants in the short term (12 months of follow-up). Future RCTs are warranted to evaluate the long-term outcomes of zirconia implants. CLINICAL RELEVANCE: Zirconia implants may be the procedure of choice, particularly in the aesthetic zone, since they show a similar survival and success rate as titanium implants on a short-term follow-up. TRIAL REGISTRATION: Systematic review registration number-CRD42021288704 (PROSPERO)

Digital printing of enzymes on textile substrates as functional materials

Recently, there have been significant developments in inkjet printing for applications in various fields such as medicine, biomaterials and sensors. In this research, enzymes like horseradish peroxidase (HRP) and glucose oxidase (GOx) were directly printed by inkjet printer onto flexible textile fabric in predefined patterns to produce a functional material. The functionality of the printed enzymes (bioink) was investigated by chemical reaction after printing fresh and stored bio-ink in a digital printer. The results indicated that these enzymes can be effectively printed individually or in combination, which retains their functionality after printing. Furthermore, HRP was coupled and printed with fluorescent group, the result confirmed that the printed enzyme was still active and retained its functionality despite the printing process. Hence, the digital printing technique can be used as a novel method for producing functional textiles for advanced applications in monitoring health and security

An Unusual Foreign Body in the Maxillary Antrum: A Case Report and Pertinent Review of Literature

Maxillary sinus is the largest of the paranasal sinuses and occupies the body of Maxilla. It is pyramidal in shape with base toward lateral wall of nose and apex directed laterally into thezygomatic process. It is roof is formed by the floor of the orbit and grooved by infraorbital nerve. Foreign bodies may present in the paranasal sinuses through a variety of traumatic andiatrogenic events. We describe a case where a sharp foreign body penetrated into the maxillary sinus. We used the open surgical approach, for the removal of sinus foreign body

Biogeography of the water flea Daphnia O. F. Müller (Crustacea: Branchiopoda: Anomopoda) on the Indian subcontinent

© 2016, Journal of Limnology. All rights reserved.Studies on Daphnia distribution in Indian subcontinent have been few and regionally restricted despite Daphnia being by far the most studied cladoceran. We here present a first biogeographical assessment of the genus on the Indian subcontinent (Afghanistan, Pakistan, India, Nepal, Bhutan, Bangladesh and Sri Lanka). We collected all pertinent literature and considered nineteen bioclimatic variables along with latitude, longitude, and altitude for statistical analysis of factors governing distribution in space. Significant variables (determined by Kruskal Wallis test) were tested by nonparametric multivariate analysis of variance (PERMANOVA) to clarify whether Daphnia species had specific environmental requirements. Canonical correspondence analysis was used to understand how environmental variables affected distribution. Eight Daphnia (Ctenodaphnia) and 4 Daphnia s.str. occurred at 100 different localities. The variables temperature, altitude and latitude differed among species and so did their bio-climatic requirements. Daphnia distribution responded positively to altitude and negatively to a decrease in latitude and temperature. We confirm the existence of three complexes of Daphnia in the Indian subcontinent: i) widely distributed species and species complexes; ii) high altitude endemics; and iii) low latitude D. (Ctenodaphnia) species

Binuclear Manganese(III) Complexes as Electron Donors in D1/D2/Cytochrome b559 Preparations Isolated from Spinach Photosystem II Membrane Fragments

The capability of different manganese complexes to act as PS II electron donors in D1/D2/ cytochrome b 559 complexes has been analyzed by measuring actinic light-induced absorption changes at 680 nm (650 nm) and 340 nm, reflecting the photoaccumulation of Pheophytin- (Pheo-) and the reduction of NADP+ respectively. The data obtained reveal: a) the donor capacity of synthetic binuclear Mn(III)2 complexes containing aromatic ligands significantly exceeds that for MnCl2 in both cases, i.e. Pheo- photoaccumulation and NADP+ reduction; b) manganese complexes can serve as suitable electron donors for light-induced NADP+ reduction catalyzed by D1/D2/cytochrome b559 complexes and ferredoxin plus ferredoxin- NADP+ reductase under anaerobic conditions and c) the specific turnover rate of the system leading to NADP+ reduction is extremely small. The implications of these findings are briefly discussed

Finite size scaling in the solar wind magnetic field energy density as seen by WIND

Statistical properties of the interplanetary magnetic field fluctuations can provide an important insight into the solar wind turbulent cascade. Recently, analysis of the Probability Density Functions (PDF) of the velocity and magnetic field fluctuations has shown that these exhibit non-Gaussian properties on small time scales while large scale features appear to be uncorrelated. Here we apply the finite size scaling technique to explore the scaling of the magnetic field energy density fluctuations as seen by WIND. We find a single scaling sufficient to collapse the curves over the entire investigated range. The rescaled PDF follow a non Gaussian distribution with asymptotic behavior well described by the Gamma distribution arising from a finite range Lévy walk. Such mono scaling suggests that a Fokker-Planck approach can be applied to study the PDF dynamics. These results strongly suggest the existence of a common, nonlinear process on the time scale up to 26 hours

Finite time singularities in a class of hydrodynamic models

Models of inviscid incompressible fluid are considered, with the kinetic energy (i.e., the Lagrangian functional) taking the form ${\cal L}\sim\int k^\alpha|{\bf v_k}|^2d^3{\bf k}$ in 3D Fourier representation, where $\alpha$ is a constant, $0<\alpha< 1$. Unlike the case $\alpha=0$ (the usual Eulerian hydrodynamics), a finite value of $\alpha$ results in a finite energy for a singular, frozen-in vortex filament. This property allows us to study the dynamics of such filaments without the necessity of a regularization procedure for short length scales. The linear analysis of small symmetrical deviations from a stationary solution is performed for a pair of anti-parallel vortex filaments and an analog of the Crow instability is found at small wave-numbers. A local approximate Hamiltonian is obtained for the nonlinear long-scale dynamics of this system. Self-similar solutions of the corresponding equations are found analytically. They describe the formation of a finite time singularity, with all length scales decreasing like $(t^*-t)^{1/(2-\alpha)}$, where $t^*$ is the singularity time.Comment: LaTeX, 17 pages, 3 eps figures. This version is close to the journal pape

Hamiltonian magnetohydrodynamics: symmetric formulation, Casimir invariants, and equilibrium variational principles

The noncanonical Hamiltonian formulation of magnetohydrodynamics (MHD) is used to construct variational principles for symmetric equilibrium configurations of magnetized plasma including flow. In particular, helical symmetry is considered and results on axial and translational symmetries are retrieved as special cases of the helical configurations. The symmetry condition, which allows the description in terms of a magnetic flux function, is exploited to deduce a symmetric form of the noncanonical Poisson bracket of MHD. Casimir invariants are then obtained directly from the Poisson bracket. Equilibria are obtained from an energy-Casimir principle and reduced forms of this variational principle are obtained by the elimination of algebraic constraints.Comment: submitted to Physics of Plasmas, 16 page

DNAJA1 controls the fate of misfolded mutant p53 through the mevalonate pathway

Stabilization of mutant p53 (mutp53) in tumours greatly contributes to malignant progression. However, little is known about the underlying mechanisms and therapeutic approaches to destabilize mutp53. Here, through high-throughput screening we identify statins, cholesterol-lowering drugs, as degradation inducers for conformational or misfolded p53 mutants with minimal effects on wild-type p53 (wtp53) and DNA contact mutants. Statins preferentially suppress mutp53-expressing cancer cell growth. Specific reduction of mevalonate-5-phosphate by statins or mevalonate kinase knockdown induces CHIP ubiquitin ligase-mediated nuclear export, ubiquitylation, and degradation of mutp53 by impairing interaction of mutp53 with DNAJA1, a Hsp40 family member. Knockdown of DNAJA1 also induces CHIP-mediated mutp53 degradation, while its overexpression antagonizes statin-induced mutp53 degradation. Our study reveals that DNAJA1 controls the fate of misfolded mutp53, provides insights into potential strategies to deplete mutp53 through the mevalonate pathway–DNAJA1 axis, and highlights the significance of p53 status in impacting statins’ efficacy on cancer therapy