Accompagnare al riconoscimento delle Competenze Chiave Europee nelle Piccole e Medie Imprese: il ruolo dell'analisi del lavoro

Il presente contributo affronta il tema del riconoscimento e validazione delle competenze chiave europee in contesto lavorativo e nelle situazioni di lavoro e produzione. La ricerca-intervento presentata, condotta in un distretto di artigianato industriale della moda di lusso italiano, illustra alcuni fattori per un\u2019efficace progettazione e conduzione del dispositivo al fine di giungere all\u2019auspicata trasformazione delle pratiche, delle rappresentazioni dei ruoli organizzativi e del genere professionale: la tipologia di apprendimenti, prevalentemente taciti e situati, la necessit\ue0 di repertori contestualizzati alle situazioni di lavoro, la personalizzazione dell\u2019accompagnamento in funzione delle capacit\ue0 riflessive e di concettualizzazione degli attori aziendali e, non ultimo, la valorizzazione della dimensione collettiva. L\u2019analisi del lavoro e la Didattica Professionale possono fornire il quadro teorico e gli strumenti metodologici per rispondere a tali esigenze, sia sul piano della progettazione formativa, che della progettazione e conduzione dell\u2019accompagnamento

The candidates’ counselling in the validation of informal and nonformal learning

The validation of the competences acquired other than by formal means is a current preoccupation at national and European policies level, an opportunity for the young and the adult people alike, a desire, but at the same time a reality of everyday life. The optimal conducting of the validation of nonformal and informal learning entails, according to the European documents, the supporting of candidates. The article presents, in its first part three case studies from different national contexts, Romania, France and Italy, focused on the counselling activity, In its second part, the article analyses the perception of a counselling framework possibly to be implemented in the human resources departments of Romanian companies as a complementary manner to the counselling offered by accredited evaluation centres

V617F Jak2 mutation in children with essential thrombocythemia (ET)

none5noneRANDI M.L.; PUTTI MC; SCAPIN M; PACQUOLA E; FABRIS FRandi, MARIA LUIGIA; Putti, Mc; Scapin, M; Pacquola, E; Fabris, Fabrizi

Gestione dell’ittero ostruttivo da neoplasia bilio-pancreatica

ackground: Neoplasms of the bilio-pancreatic tract are often disgnosed in an advanced stage. Palliation of these patients is focused on resolution of biliary obstruction. Methods: From 1 January 2003 to 31 January 2009 we managed 39 patients with a palliative procedure, 8 of them were treated by a surgical by-pass, the endoscopic procedures were 21, while the transepatic percutaneous drainages were 12. Discussion: Surgical palliation is reserved for patients with a good performance status and expected survival of over 6 mounths, it is also indicated for whom, affected by pancreatic carcinoma, developed duodenal obstruction associated to jaundice. If the biliary obstruction is near the papillary region the treatment of choice is endoscopic drainage, if the obstruction is distal these region the way of choice is the transepatic one. Metallic stents have a greater initial cost but a less risk of obstruction than the plastic stents, these are indicated in patients with a short survival expectance. Conclusions: Endoscopic drainage is the gold standard of treatment for obstructive jaundice, percutaneous biliary decompressione is the treatment of choice for palliation of distal bile obstruction

Pediatric patients with essential thrombocythemia are mostly polyclonal and V617FJAK2 negative.

Essential thrombocythemia (ET) is rare in children, and little or no information is available about clonality or JAK2 mutations. However, the analyses in this work prove useful for the diagnosis of adult myeloproliferative disorders (MPDs). We evaluated the clonality status and V617FJAK2 mutation in 20 children affected by ET and compared them with 47 consecutive adult ET cases. Clonality was evaluated on the DNA of granulocytes and on the RNA of platelets. V617FJAK2 was analyzed by sequencing tests, allele-specific polymerase chain reaction (PCR), and digestion by BsaXI. A monoclonal pattern was found in 4 (28.5%) of 14 children and in 45% of informative adults. Heterozygous V617FJAK2 was found less frequently in children than in adults (P < .009). Only 2 girls showed both the V617FJAK2 mutation and a monoclonal pattern; one of them was the only child presenting a major thrombotic complication. In contrast to adults, most children with ET do not show either a clonal disorder or the V617FJAK2 mutation

Role of blood cells dynamism on hemostatic complications in low-risk patients with essential thrombocythemia.

Patients with essential thrombocythemia (ET) aged less than 60 years, who have not suffered a previous vascular event (low-risk patients), may develop thrombotic or hemorrhagic events. So far, it has not been possible to identify useful markers capable of predicting which of these patients are more likely to develop an event and therefore who needs to be treated. In the present study, we analysed the relationship between vascular complications and longitudinal blood counts of 136 low-risk ET patients taken over a sustained period of time (blood cells dynamism). After a median follow-up of 60 months, 45 out of 136 patients (33 %) suffered 40 major thrombotic and 5 severe hemorrhagic complications. A total number of 5,781 blood counts were collected longitudinally. Thrombotic and hemorrhagic events were studied together (primary endpoint) but also separately (thrombotic alone = secondary endpoint; hemorrhagic alone = tertiary endpoint). The primary endpoint showed no significant association between platelet and WBC count at diagnosis and risk of any event (platelet, p = 0.797; WBC, p = 0.178), while Hb at baseline did show an association (p = 0.024). In the dynamic analysis with Cox regression model, where the blood count values were studied by time of follow-up, we observed that the risk for Hb was 1.49 (95 % CI 1.13-1.97) for every increase of 1 g/dL, and that this risk then marginally decreased during follow-up. WBC was associated with an increased risk at baseline for every increase of 1 7 109/L (hazard ratio (HR) 1.07, 95 % CI 1.01-1.13, p = 0.034), the risk was stable during follow-up (HR 0.95, p = 0.187 at 60 months). Also, for each increment at baseline of 100 7 109 platelets/L, HR was increased by 1.08 (95 % CI 0.97-1.22, p = 0.159) and decreases during follow-up. In conclusion, this study is the first to evaluate in ET low-risk patients, the risk of developing a thrombotic/hemorrhagic event considering blood counts over time. Overall our study shows that the risk changes over time. For example, the risk associated with WCC is not linear as previously reported. An interesting new finding is that PLT and even Hb contribute to the risk of developing vascular events. Future treatments should take into consideration these findings and aim to control all parameters over time. We believe this early study may help develop a dynamic analysis model to predict thrombosis in the single patient. Further studies are now warranted to further validate our findings