Prognostic significance of anti-p53 and anti-KRas circulating antibodies in esophageal cancer patients treated with chemoradiotherapy

<p>Abstract</p> <p>Background</p> <p>P53 mutations are an adverse prognostic factor in esophageal cancer. P53 and KRas mutations are involved in chemo-radioresistance. Circulating anti-p53 or anti-KRas antibodies are associated with gene mutations. We studied whether anti-p53 or anti-KRas auto-antibodies were prognostic factors for response to chemoradiotherapy (CRT) or survival in esophageal carcinoma.</p> <p>Methods</p> <p>Serum p53 and KRas antibodies (abs) were measured using an ELISA method in 97 consecutive patients treated at Saint Louis University Hospital between 1999 and 2002 with CRT for esophageal carcinoma (squamous cell carcinoma (SCCE) 57 patients, adenocarcinoma (ACE) 27 patients). Patient and tumor characteristics, response to treatment and the follow-up status of 84 patients were retrospectively collected. The association between antibodies and patient characteristics was studied. Univariate and multivariate survival analyses were conducted.</p> <p>Results</p> <p>Twenty-four patients (28%) had anti-p53 abs. Abs were found predominantly in SCCE (p = 0.003). Anti-p53 abs were associated with a shorter overall survival in the univariate analysis (HR 1.8 [1.03-2.9], p = 0.04). In the multivariate analysis, independent prognostic factors for overall and progression-free survival were an objective response to CRT, the CRT strategy (alone or combined with surgery [preoperative]) and anti-p53 abs. None of the long-term survivors had p53 abs. KRas abs were found in 19 patients (23%, no difference according to the histological type). There was no significant association between anti-KRas abs and survival neither in the univariate nor in the multivariate analysis. Neither anti-p53 nor anti-KRas abs were associated with response to CRT.</p> <p>Conclusions</p> <p>Anti-p53 abs are an independent prognostic factor for esophageal cancer patients treated with CRT. Individualized therapeutic approaches should be evaluated in this population.</p

Pain after total hip arthroplasty: a psychiatric point of view

After total hip arthroplasty (THA), many studies report that a small percentage of patients mention painful symptoms, whose origin remains more or less obscure. We investigated 1,000 patients who had undergone a THA at least one year before their inclusion in the survey protocol. Among these 1,000 patients, 64 were complaining of pain in the region of the operated hip. These were later examined and investigated, both clinically (physical and psychiatric examination) and paraclinically (radiography, biology). Those requiring it received adequate treatment and the others were only regularly followed up. We identified the cause of all but one patient’s pain. In all cases except one, the symptoms of pain without physical cause had a psychiatric origin. The results of our study show that, if the clinical picture is not perfectly clear, a psychiatric screening before surgery could contribute to decreasing the incidence of pain syndrome after THA

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Réactions chimiques et diffusion : sources de structuration spatio-temporelle

On traite des structures spatiales induites par le couplage entre réaction chimique et diffusion des especes en solution aqueuse, en réacteur ouvert ou non. Après un rappel théorique, on décrit les désormais classiques structures cibles et spirales, puis differentes structures spatiales entretenues unidimensionnelles (stationnaires ou oscillantes) ou bidimensionnelles (ondes d’excitation cycliques) de découverte récente

Matériaux composites carbone carbone conditions de fabrication par dépôt chimique en phase vapeur microstructures et propriétés physiques

Les conditions expérimentales du dépôt chimique en phase vapeur de Carbone sur un substrat fibreux, conduisant à un composite Carbone/Carbone, sont systématiquement étudiées en fonction des contraintes : température de dépôt, débit et taux de méthane, taux initial de fibres du substrat. Les différentes microstructures de pyrocarbone (laminaire rugueux, laminaire lisse, isotrope) sont caractérisées par microscopie optique et microscopie électronique en transmission, densité de grain et mesures magnétiques (susceptibilité et anisotropie). En choisissant des couples de contraintes, on a établi plusieurs coupes du diagramme d'existence de chaque microstructure. Enfin, une évaluation des caractéristiques mécaniques en flexion “trois points” conduit à une tentative de corrélation entre la résistance mécanique, la microstructure de la matrice de pyrocarbone et les conditions de fabrication du matériau composite

Étude de la structure électronique de carbones prégraphitiques

On a étudié l’effet Hall, la magnétorésistance, la résistivité, la susceptibilité magnétique, et la résonance paramagnétique électronique d’un coke de brai, ainsi que l’évolution de ces propriétés au cours de la graphitisation. Les résultats sont généralement en bone accord avec ceux d’études antérieures menées sur des carbones de ce type. Certaines convergences qualitatives permettent de distinguer deux domaines « critiques » de températures de traitement. Le nombre des porteurs de charges libres déterminé par la résonance paramagnétique concorde remarquablement avec celui que l’on obtient à partir du diamagnétisme à basse température