The Zero-Point Field and Inertia

A brief overview is presented of the basis of the electromagnetic zero-point field in quantum physics and its representation in stochastic electrodynamics. Two approaches have led to the proposal that the inertia of matter may be explained as an electromagnetic reaction force. The first is based on the modeling of quarks and electrons as Planck oscillators and the method of Einstein and Hopf to treat the interaction of the zero-point field with such oscillators. The second approach is based on analysis of the Poynting vector of the zero-point field in accelerated reference frames. It is possible to derive both Newton's equation of motion, F=ma, and its relativistic co-variant form from Maxwell's equations as applied to the zero-point field of the quantum vacuum. This appears to account, at least in part, for the inertia of matter.Comment: 8 pages, no fig

Penetration of boundary-driven flows into a rotating spherical thermally stratified fluid

Motivated by the dynamics within terrestrial bodies, we consider a rotating, strongly thermally stratified fluid within a spherical shell subject to a prescribed laterally inhomogeneous heat-flux condition at the outer boundary. Using a numerical model, we explore a broad range of three key dimensionless numbers: a thermal stratification parameter (the relative size of boundary temperature gradients to imposed vertical temperature gradients), 10^−3 ≤ S ≤ 10^4, a buoyancy parameter (the strength of applied boundary heat-flux anomalies), 10^−2 ≤ B ≤ 10^6, and the Ekman number (ratio of viscous to Coriolis forces), 10^−6 ≤ E ≤ 10^−4. We find both steady and time-dependent solutions and delineate the regime boundaries. We focus on steady-state solutions, for which a clear transition is found between a low S regime, in which buoyancy dominates the dynamics, and a high S regime, in which stratification dominates. For the low-S regime, we find that the characteristic flow speed scales as B^2/3, whereas for high-S, the radial and horizontal velocities scale respectively as ur ~ S^−1, uh ~S^−3/4 B^1/4 and are confined within a thin layer of depth (SB)^−1/4 at the outer edge of the domain. For the Earth, if lower mantle heterogeneous structure is due principally to chemical anomalies, we estimate that the core is in the high-S regime and steady flows arising from strong outer boundary thermal anomalies cannot penetrate the stable layer. However, if the mantle heterogeneities are due to thermal anomalies and the heat-flux variation is large, the core will be in a low-S regime in which the stable layer is likely penetrated by boundary-driven flows

Fast Directional Changes during Geomagnetic Transitions: Global Reversals or Local Fluctuations?

Paleomagnetic investigations from sediments in Central and Southern Italy found directional changes of the order of 10∘ per year during the last geomagnetic field reversal (which took place about 780,000 years ago). These values are orders of magnitudes larger than what is expected from the estimated millennial timescales for geomagnetic field reversals. It is yet unclear whether these extreme changes define the timescale of global dipolar change or whether they indicate a rapid, but spatially localised feature that is not indicative of global variations. Here, we address this issue by calculating the minimum amount of kinetic energy that flows at the top of the core required to instantaneously reproduce these two scenarios. We found that optimised flow structures compatible with the global-scale interpretation of directional change require about one order of magnitude more energy than those that reproduce local change. In particular, we found that the most recently reported directional variations from the Sulmona Basin, in Central Italy, can be reproduced by a core-surface flow with rms values comparable to, or significantly lower than, present-day estimates of about 8 to 22 km/y. Conversely, interpreting the observations as global changes requires rms flow values in excess of 77 km/y, with pointwise maximal velocities of 127 km/y, which we deem improbable. We therefore concluded that the extreme variations reported for the Sulmona Basin were likely caused by a local, transient feature during a longer transition

Thermal Structure of Eastern Australia's Upper Mantle and Its Relationship to Cenozoic Volcanic Activity and Dynamic Topography

Funder: Geoscience AustraliaFunder: Shell Global, Shell Exploration and Production Company; Id: http://dx.doi.org/10.13039/100011092Abstract: Spatio‐temporal changes of upper mantle structure play a significant role in generating and maintaining surface topography. Although geophysical models of upper mantle structure have become increasingly refined, there is a paucity of geologic constraints with respect to its present‐day state and temporal evolution. Cenozoic intraplate volcanic rocks that crop out across eastern Australia provide a significant opportunity to quantify mantle conditions at the time of emplacement and to independently validate geophysical estimates. This volcanic activity is divided into two categories: age‐progressive provinces that are generated by the sub‐plate passage of mantle plumes and age‐independent provinces that could be generated by convective upwelling at lithospheric steps. In this study, we acquired and analyzed 78 samples from both types of provinces across Queensland. These samples were incorporated into a comprehensive database of Australian Cenozoic volcanism assembled from legacy analyses. We use geochemical modeling techniques to estimate mantle temperature and lithospheric thickness beneath each province. Our results suggest that melting occurred at depths ≤80 km across eastern Australia. Prior to, or coincident with, onset of volcanism, lithospheric thinning as well as dynamic support from shallow convective processes could have triggered uplift of the Eastern Highlands. Mantle temperatures are inferred to be ∼50–100°C hotter beneath age‐progressive provinces that demarcate passage of the Cosgrove mantle plume than beneath age‐independent provinces. Even though this plume initiated as one of the hottest recorded during Cenozoic times, it appears to have thermally waned with time. These results are consistent with xenolith thermobarometric and geophysical studies

Aspergillus fumigatus and its Allergenic Ribotoxin Asp f I: Old Enemies but New Opportunities for Urine-based Detection of Invasive Pulmonary Aspergillosis using Lateral-Flow Technology

This is the final version. Available on open access from MDPI via the DOI in this recordData Availability Statement: The data presented in this study are available on request from the corresponding author. The data are not publicly available due to commercial confidentialities.Invasive pulmonary aspergillosis (IPA) caused by Aspergillus fumigatus is a life-threatening lung disease of immunocompromised patients. Diagnosis currently relies on non-specific chest CT, culture of the fungus from invasive lung biopsy, and detection of the cell wall carbohydrate galactomannan (GM) in serum or in BAL fluids recovered during invasive bronchoscopy. Urine provides an ideal bodily fluid for the non-invasive detection of pathogen biomarkers, with current urine-based immunodiagnostics for IPA focused on GM. Surrogate protein biomarkers might serve to improve disease detection. Here, we report the development of a monoclonal antibody (mAb), PD7, which is specific to A. fumigatus and related species in the Section Fumigati, and which binds to its 18 kDa ribotoxin Asp f I. Using PD7, we show that the protein is secreted during hyphal development, and so represents an ideal candidate for detecting invasive growth. We have developed a lateral-flow device (Afu-LFD®) incorporating the mAb which has a limit of detection of ~15 ng Asp f I/mL urine. Preliminary evidence of the test’s diagnostic potential is demonstrated with urine from a patient with acute lymphoid leukaemia with probable IPA. The Afu-LFD® therefore provides a potential novel opportunity for non-invasive urine-based detection of IPA caused by A. fumigatus.Innovate U

Impact of the Mk VI SkinSuit on skin microbiota of terrestrial volunteers and an International Space Station-bound astronaut

Microgravity induces physiological deconditioning due to the absence of gravity loading, resulting in bone mineral density loss, atrophy of lower limb skeletal and postural muscles, and lengthening of the spine. SkinSuit is a lightweight compression suit designed to provide head-to-foot (axial) loading to counteract spinal elongation during spaceflight. As synthetic garments may impact negatively on the skin microbiome, we used 16S ribosomal RNA (rRNA) gene amplicon procedures to define bacterial skin communities at sebaceous and moist body sites of five healthy male volunteers undergoing SkinSuit evaluation. Each volunteer displayed a diverse, distinct bacterial population at each skin site. Short (8 h) periods of dry hyper-buoyancy flotation wearing either gym kit or SkinSuit elicited changes in the composition of the skin microbiota at the genus level but had little or no impact on community structure at the phylum level or the richness and diversity of the bacterial population. We also determined the composition of the skin microbiota of an astronaut during pre-flight training, during an 8-day visit to the International Space Station involving two 6–7 h periods of SkinSuit wear, and for 1 month after return. Changes in composition of bacterial skin communities at five body sites were strongly linked to changes in geographical location. A distinct ISS bacterial microbiota signature was found which reversed to a pre-flight profile on return. No changes in microbiome complexity or diversity were noted, with little evidence for colonisation by potentially pathogenic bacteria; we conclude that short periods of SkinSuit wear induce changes to the composition of the skin microbiota but these are unlikely to compromise the healthy skin microbiome

Identification of Ventricular Tachycardia Using Intracavitary Ventricular Electrograms: Analysis of Time and Frequency Domain Patterns

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/74961/1/j.1540-8159.1988.tb06279.x.pd

Early and efficient detection of Mycobacterium tuberculosis in sputum by microscopic observation of broth cultures.

Early, efficient and inexpensive methods for the detection of pulmonary tuberculosis are urgently needed for effective patient management as well as to interrupt transmission. These methods to detect M. tuberculosis in a timely and affordable way are not yet widely available in resource-limited settings. In a developing-country setting, we prospectively evaluated two methods for culturing and detecting M. tuberculosis in sputum. Sputum samples were cultured in liquid assay (micro broth culture) in microplate wells and growth was detected by microscopic observation, or in Löwenstein-Jensen (LJ) solid media where growth was detected by visual inspection for colonies. Sputum samples were collected from 321 tuberculosis (TB) suspects attending Bugando Medical Centre, in Mwanza, Tanzania, and were cultured in parallel. Pulmonary tuberculosis cases were diagnosed using the American Thoracic Society diagnostic standards. There were a total of 200 (62.3%) pulmonary tuberculosis cases. Liquid assay with microscopic detection detected a significantly higher proportion of cases than LJ solid culture: 89.0% (95% confidence interval [CI], 84.7% to 93.3%) versus 77.0% (95% CI, 71.2% to 82.8%) (p = 0.0007). The median turn around time to diagnose tuberculosis was significantly shorter for micro broth culture than for the LJ solid culture, 9 days (interquartile range [IQR] 7-13), versus 21 days (IQR 14-28) (p<0.0001). The cost for micro broth culture (labor inclusive) in our study was US $4.56 per sample, versus US$11.35 per sample for the LJ solid culture. The liquid assay (micro broth culture) is an early, feasible, and inexpensive method for detection of pulmonary tuberculosis in resource limited settings