The effect of dopamine agonists on adaptive and aberrant salience in Parkinson's disease

Clinical evidence suggests that after initiation of dopaminergic medications some patients with Parkinson's disease (PD) develop psychotic symptoms, such as hallucinations and delusions. Here, we tested the hypothesis that the neurocognitive basis of this phenomenon can be defined as the formation of arbitrary and illusory associations between conditioned stimuli and reward signals, called aberrant salience. Young, never-medicated PD patients and matched controls were assessed on a speeded reaction time task in which the probe stimulus was preceded by conditioned stimuli that could signal monetary reward by color or shape. The patients and controls were re-evaluated after 12 weeks during which the patients received a dopamine agonist (pramipexole or ropinirole). Results indicated that dopamine agonists increased both adaptive and aberrant salience in PD patients, that is, formation of real and illusory associations between conditioned stimuli and reward, respectively. This effect was present when associations were assessed by means of faster responding after conditioned stimuli signaling reward (implicit salience) and overt rating of stimulus-reward links (explicit salience). However, unusual feelings and experiences, which are subclinical manifestations of psychotic-like symptoms, were specifically related to irrelevant and illusory stimulus-reward associations (aberrant salience) in PD patients receiving dopamine agonists. The learning of relevant and real stimulus-reward associations (adaptive salience) was not related to unusual experiences. These results suggest that dopamine agonists may increase psychotic-like experiences in young patients with PD, possibly by facilitating dopaminergic transmission in the ventral striatum, which results in aberrant associations between conditioned stimuli and reward

Dentists make larger holes in teeth than they need to if the teeth present a visual illusion of size

Background: Health care depends, in part, on the ability of a practitioner to see signs of disease and to see how to treat it. Visual illusions, therefore, could affect health care. Yet there is very little prospective evidence that illusions can influence treatment. We sought such evidence. Methods & Results: We simulated treatment using dentistry as a model system. We supplied eight, practicing, specialist dentists, endodontists, with at least 21 isolated teeth each, randomly sampled from a much larger sample of teeth they were likely to encounter. Teeth contained holes and we asked the endodontists to cut cavities in preparation for filling. Each tooth presented a more or less potent version of a visual illusion of size, the Delboeuf illusion, that made the holes appear smaller than they were. Endodontists and the persons measuring the cavities were blind to the parameters of the illusion. We found that the size of cavity endodontists made was linearly related to the potency of the Delboeuf illusion (pd) of 1.41. When the illusion made the holes appear smaller, the endodontists made cavities larger than needed. Conclusions: The visual context in which treatment takes place can influence the treatment. Undesirable effects of visual illusions could be counteracted by a health practitioner’s being aware of them and by using measurement

Submarine canyons and gullies

Submarine canyons are deep incisions observed along most of the world’s continental margins. Their topographic relief is as dramatic as that of any canyon or river valley on land but is hidden beneath the surface of the ocean. Our knowledge of canyons has therefore come primarily from remote sensing and sampling, and has involved contributions from various oceanographic disciplines. Canyons are a critical link between coastal and shelf waters and abyssal depths; water masses, sediment, nutrients, and even litter and pollutants are carried through them. Advances in technology continue to provide new insights into canyon environments by pushing the frontier of deep marine observations and measurements. In this chapter we describe the main geomorphic features of submarine canyons and what is known about their formation and the processes that shape them. We also consider submarine gullies, which are small valleys commonly found within or alongside submarine canyons on the continental slope and may represent an incipient stage of canyon development. © 2018, Springer International Publishing AG