26 research outputs found
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Investigating the role of the Liver X Receptor in Potentiating Mitotane Therapy in Adrenocortical Carcinoma
No full textAdrenocortical carcinoma (ACC) is a rare, aggressive malignancy. Adjuvant mitotane improves survival but is limited by its narrow therapeutic window and escape from therapeutic efficacy. Mitotane modulates its adrenolytic effect through SOAT1 antagonism and consequent free cholesterol accumulation. Liver X receptors (LXRs), are highly expressed in adrenal tissue and mediate cholesterol homeostasis. We hypothesise that selective antagonism of LXRα increases toxic lipid accumulation in adrenocortical cells and potentiates the adrenolytic effect of mitotane
The treatment of acute agitation associated with schizophrenia or bipolar disorder: investigational drugs in early stages of their clinical development, and their clinical context and potential place in therapy
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Video Display Terminal Operation: A Potential Risk in the Etiology and Maintenance of Temporomandibular Disorders
No full textNeuroleptic medication and prescription practices with sheltered-care residents: a 12-year perspective.
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Use of the Social Behaviour Assessment Schedule (SBAS) in a trial of maintenance antipsychotic therapy in schizophrenic outpatients: Pimozide versus fluphenazine
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