Altered functional brain network connectivity and glutamate system function in transgenic mice expressing truncated Disrupted-in-Schizophrenia 1

Considerable evidence implicates DISC1 as a susceptibility gene for multiple psychiatric diseases. DISC1 has been intensively studied at the molecular, cellular and behavioral level, but its role in regulating brain connectivity and brain network function remains unknown. Here, we utilize a set of complementary approaches to assess the functional brain network abnormalities present in mice expressing a truncated Disc1 gene (Disc1tr Hemi mice). Disc1tr Hemi mice exhibited hypometabolism in the prefrontal cortex (PFC) and reticular thalamus along with a reorganization of functional brain network connectivity that included compromised hippocampal–PFC connectivity. Altered hippocampal–PFC connectivity in Disc1tr Hemi mice was confirmed by electrophysiological analysis, with Disc1tr Hemi mice showing a reduced probability of presynaptic neurotransmitter release in the monosynaptic glutamatergic hippocampal CA1–PFC projection. Glutamate system dysfunction in Disc1tr Hemi mice was further supported by the attenuated cerebral metabolic response to the NMDA receptor (NMDAR) antagonist ketamine and decreased hippocampal expression of NMDAR subunits 2A and 2B in these animals. These data show that the Disc1 truncation in Disc1tr Hemi mice induces a range of translationally relevant endophenotypes underpinned by glutamate system dysfunction and altered brain connectivity

Land resource assessment of Northern Belize (NRI Bulletin 43, Volume 2 of 2)

The land resource assessment was undertaken from July 1989 to June 1990 by the Natural Resources Institute (NRI) of the Overseas Development Administration (ODA), assisted by Mr. A. C. S. Wright, and Dr. M. Holder of Central Farm. The main object of the survey was to produce an updated land suitability assessment of Orange Walk, Corozal, Belize and Cayo districts which had not already been surveyed by Jenkin et al. (1976) and King et al. (1989). In addition, this survey would provide a land suitability assessment for the Belize Valley based on the soil mapping of )en kin et al. Thus, together with the land resource assessments of Toledo and Stann Creek districts (King et al., 1986, 1989 respectively), a land suitability assessment for the whole of Belize is now available

Land resource assessment of Northern Belize (NRI Bulletin 43, Volume 1 of 2)

The land resource assessment was undertaken from July 1989 to June 1990 by the Natural Resources Institute (NRI) of the Overseas Development Administration (ODA), assisted by Mr. A. C. S. Wright, and Dr. M. Holder of Central Farm. The main object of the survey was to produce an updated land suitability assessment of Orange Walk, Corozal, Belize and Cayo districts which had not already been surveyed by Jenkin et al. (1976) and King et al. (1989). In addition, this survey would provide a land suitability assessment for the Belize Valley based on the soil mapping of )en kin et al. Thus, together with the land resource assessments of Toledo and Stann Creek districts (King et al., 1986, 1989 respectively), a land suitability assessment for the whole of Belize is now available

Finite temperature pion vector form factors in Chiral Perturbation Theory

We discuss the thermal behaviour of the pion vector form factors and calculate them in one-loop Chiral Perturbation Theory. The perturbative result is used to analyze the $T$-dependent electromagnetic pion charge radius, obtaining a rough estimate of the deconfinement critical temperature. Imposing thermal unitarity, we generate the $\rho$ resonance pole for the form factor in the center of mass frame. The $\rho$ peak height in the modulus of the form factor decreases for increasing temperature, while its width increases and the peak position is slightly shifted downwards for $T\simeq$ 150 MeV. These results point in the direction suggested by many analysis of dilepton production data in relativistic heavy ion collisions.Comment: 15 pages, 4 figures, final version to appear in Phys.Lett.B, added references and comments, abstract change

Defects and glassy dynamics in solid He-4: Perspectives and current status

We review the anomalous behavior of solid He-4 at low temperatures with particular attention to the role of structural defects present in solid. The discussion centers around the possible role of two level systems and structural glassy components for inducing the observed anomalies. We propose that the origin of glassy behavior is due to the dynamics of defects like dislocations formed in He-4. Within the developed framework of glassy components in a solid, we give a summary of the results and predictions for the effects that cover the mechanical, thermodynamic, viscoelastic, and electro-elastic contributions of the glassy response of solid He-4. Our proposed glass model for solid He-4 has several implications: (1) The anomalous properties of He-4 can be accounted for by allowing defects to freeze out at lowest temperatures. The dynamics of solid He-4 is governed by glasslike (glassy) relaxation processes and the distribution of relaxation times varies significantly between different torsional oscillator, shear modulus, and dielectric function experiments. (2) Any defect freeze-out will be accompanied by thermodynamic signatures consistent with entropy contributions from defects. It follows that such entropy contribution is much smaller than the required superfluid fraction, yet it is sufficient to account for excess entropy at lowest temperatures. (3) We predict a Cole-Cole type relation between the real and imaginary part of the response functions for rotational and planar shear that is occurring due to the dynamics of defects. Similar results apply for other response functions. (4) Using the framework of glassy dynamics, we predict low-frequency yet to be measured electro-elastic features in defect rich He-4 crystals. These predictions allow one to directly test the ideas and very presence of glassy contributions in He-4.Comment: 33 pages, 13 figure

Planck 2015 results. XXVII. The Second Planck Catalogue of Sunyaev-Zeldovich Sources

We present the all-sky Planck catalogue of Sunyaev-Zeldovich (SZ) sources detected from the 29 month full-mission data. The catalogue (PSZ2) is the largest SZ-selected sample of galaxy clusters yet produced and the deepest all-sky catalogue of galaxy clusters. It contains 1653 detections, of which 1203 are confirmed clusters with identified counterparts in external data-sets, and is the first SZ-selected cluster survey containing > $10^3$ confirmed clusters. We present a detailed analysis of the survey selection function in terms of its completeness and statistical reliability, placing a lower limit of 83% on the purity. Using simulations, we find that the Y5R500 estimates are robust to pressure-profile variation and beam systematics, but accurate conversion to Y500 requires. the use of prior information on the cluster extent. We describe the multi-wavelength search for counterparts in ancillary data, which makes use of radio, microwave, infra-red, optical and X-ray data-sets, and which places emphasis on the robustness of the counterpart match. We discuss the physical properties of the new sample and identify a population of low-redshift X-ray under- luminous clusters revealed by SZ selection. These objects appear in optical and SZ surveys with consistent properties for their mass, but are almost absent from ROSAT X-ray selected samples

Detector Description and Performance for the First Coincidence Observations between LIGO and GEO

For 17 days in August and September 2002, the LIGO and GEO interferometer gravitational wave detectors were operated in coincidence to produce their first data for scientific analysis. Although the detectors were still far from their design sensitivity levels, the data can be used to place better upper limits on the flux of gravitational waves incident on the earth than previous direct measurements. This paper describes the instruments and the data in some detail, as a companion to analysis papers based on the first data.Comment: 41 pages, 9 figures 17 Sept 03: author list amended, minor editorial change