Outcomes and organ dysfunctions of critically ill patients with systemic lupus erythematosus and other systemic rheumatic diseases

Our objective was to compare the pattern of organ dysfunctions and outcomes of critically ill patients with systemic lupus erythematosus (SLE) with patients with other systemic rheumatic diseases (SRD). We studied 116 critically ill SRD patients, 59 SLE and 57 other-SRD patients. The SLE group was younger and included more women. Respiratory failure (61%) and shock (39%) were the most common causes of ICU admission for other-SRD and SLE groups, respectively. ICU length-of-stay was similar for the two groups. The 60-day survival adjusted for the groups’ baseline imbalances was not different (P = 0.792). Total SOFA scores were equal for the two groups at admission and during ICU stay, although respiratory function was worse in the other-SRD group at admission and renal and hematological functions were worse in the SLE group at admission. The incidence of severe respiratory dysfunction (respiratory SOFA >2) at admission was higher in the other-SRD group, whereas severe hematological dysfunction (hematological SOFA >2) during ICU stay was higher in the SLE group. SLE patients were younger and displayed a decreased incidence of respiratory failure compared to patients with other-SRDs. However, the incidences of renal and hematological failure and the presence of shock at admission were higher in the SLE group. The 60-day survival rates were similar

Sólidos totais do leite em amostras de tanque nos estados do Paraná, Santa Catarina e São Paulo Milk total solids in bulk tank samples of Paraná, Santa Catarina and São Paulo States

Objetivou-se, neste trabalho, estudar a variação dos sólidos totais em amostras de leite de tanques de 32.590 rebanhos dos estados do Paraná, Santa Catarina e São Paulo. Foram analisadas 257.540 amostras de leite de tanques coletadas entre janeiro de 1999 e novembro de 2001, no Laboratório Central do Programa de Análise de Rebanhos Leiteiros do Paraná (PARLPR), da Associação Paranaense de Criadores de Bovinos da Raça Holandesa. Utilizando-se o método dos quadrados mínimos, foram estudados os efeitos de rebanho, região, mês e ano de análise, idade da amostra e escore de células somáticas sobre os sólidos totais, em amostras de leite de tanques. As médias ajustadas dos sólidos totais por região variaram de 11,78 a 12,83%; a maior média foi verificada em maio de 2001 e a menor, em janeiro de 2000; os sólidos totais não demonstraram variação até o quinto dia de análise; o efeito de escore de células somáticas foi contraditório, se comparado aos relatados por outros autores. Todos os fatores incluídos no modelo linear foram altamente significativos sobre as características analisadas. O coeficiente de correlação entre sólidos totais e seus componentes foi de 0,875 para gordura, 0,653 para proteína, 0,237 para lactose, e 0,643 para sólidos não-gordurosos. A correlação de sólidos totais com contagem de células somáticas foi 0,012, e com escore de células somáticas, de 0,023.<br>The objective of this research was to study the variation of total solids in bulk tank milk samples in 32,590 herds of Paraná, Santa Catarina and São Paulo states, in Brazil. A total of 257,540 bulk tank samples collected between January 1999 and November 2001 were analyzed at the Central Laboratory of the Programa de Análise dos Rebanhos Leiteiros do Paraná (PARLPR) of the Holstein Association of the state of Paraná. Least Square Means Method procedures were used to study the effects of herd, region, month and year of test, age of the sample and somatic cell score on total solids of bulk tank milk. The adjusted means of total solids by region ranged from 11.78 to 12.83%; the greatest means were in May 2001 and the smallest in January 2000; total solids did not show variation until the fifth day of analysis; the effect of cell score was contradictory, when compared with other authors. All factors included in the linear model had highly significant effect on the trait analyzed. The correlation coefficient between total solids and their components were 0.875 for fat, 0.653 for protein, 0.237 for lactose, and 0.643 for solids not fat. Correlation of total solids with somatic cell count was 0.012, and 0.023 with somatic cell score