Clinically significant drug-drug interactions between oral anticancer agents and nonanticancer agents: Profiling and comparison of two drug compendia

10.1345/aph.1L255Annals of Pharmacotherapy42121737-1748APHR

Rotating-disk-type flow over loose boundaries

Rotating-disk-type flow of a liquid over a loose boundary, such as a layer of sand, is investigated. For this flow the formation of a new large-scale spiral pattern has been discovered. The new pattern is reminiscent of the Type-I spiral-vortex structures which characterize the laminar-turbulent transition region of boundary layers over rigid rotating disks. Flow visualizations reveal that the new pattern and the Type-I spiral vortices co-exist in the loose-boundary flow. The research investigating the origin of the new large-scale pattern is reviewed. Then photographs from flow visualizations are analysed to obtain estimates for the critical Reynolds number for which Type-I spiral vortices first appear for the loose-boundary flow and for the critical Reynolds numbers for the laminar-turbulent transition of the boundary layer. The results suggest that Type-I vortices appear at much lower Reynolds numbers over loose boundaries in comparison with flow over rigid rotating disks and that transition also appears to be advanced to much lower Reynolds numbers. The discussion of the results suggests that advanced transition arises from disturbances introduced into the flow after the loose boundary has been mobilized and not from disturbances associated with the roughness that the surfaces of the granular layer represents to the flow while grains are at rest

Personalized medicine in psychiatry: problems and promises

The central theme of personalized medicine is the premise that an individual’s unique physiologic characteristics play a significant role in both disease vulnerability and in response to specific therapies. The major goals of personalized medicine are therefore to predict an individual’s susceptibility to developing an illness, achieve accurate diagnosis, and optimize the most efficient and favorable response to treatment. The goal of achieving personalized medicine in psychiatry is a laudable one, because its attainment should be associated with a marked reduction in morbidity and mortality. In this review, we summarize an illustrative selection of studies that are laying the foundation towards personalizing medicine in major depressive disorder, bipolar disorder, and schizophrenia. In addition, we present emerging applications that are likely to advance personalized medicine in psychiatry, with an emphasis on novel biomarkers and neuroimaging