A Computational Model for Continuous Cooling of Injection Moulding Processes

This paper discusses the approaches and techniques used to build a realistic numerical model to analyse the cooling phase of the injection moulding process. The procedures employed to select an appropriate mesh and the boundary and initial conditions for the problem are discussed and justified. The final model is validated using direct comparisons with experimental results generated in an earlier study. The model is shown to be a useful tool for further studies aimed at optimising the cooling phase of the injection moulding process. Using the numerical model provides additional information relating to changes in conditions throughout the process, which otherwise could not be deduced or assessed experimentally. These results, and other benefits related to the use of the model, are also discussed in the paper

Component test facilities for marine renewable energy converters

This paper describes how the PRIMaRE group at University Exeter is engaging in the establishment of appropriate reliability methods suitable for application to marine renewable devices with a key area being the production of suitable failure rate data for the marine renewable energy industry. This activity seeks to mitigate uncertainties and cost implications associated with the reliability assessment of marine energy converters (MECs) due to an omnipresent lack of applicable failure rate data. The capability of two facilities, namely i) the South Western Mooring Test Facility (SWMTF) and ii) the Dynamic Marine Component Test facility (DMaC), to perform specimen and accelerated component testing is discussed. A case study, using data from wave tank tests and numerical simulations performed for the SWMTF, serves to illustrate how evidence of component reliability under operational conditions could be provided.The authors would like to acknowledge the support of the South West Regional Development Agency through the PRIMaRE institution. They would also like to acknowledge the European Community's Sixth Framework Programme HYDRALAB III, Contract no. 022441 (RII3). The second author would like to acknowledge the funding support from the Engineering and Physical Sciences Research Council (EPSRC) under the SUPERGEN Marine Doctoral Programme. Thanks also to Orcina for provision of their Orcaflex software

Microstructural investigation of bonding and melting-induced rebound of HVOF sprayed Ni particles on an aluminum substrate

In this study, nickel powder was sprayed on a polished aluminum substrate using the high-velocity oxy-fuel spraying process. Detailed microstructural characterization was conducted to analyse the mechanims of splat formation, with particular attention to the changes occurring at the splat-substrate interface and the subsequent bonding behaviour due to the impact of high thermal and kinetic energy particles with a soft, low melting point substrate. Characterization was performed using scanning electron microscopy, focused ion beam microscopy, transmission electron microscopy, together with the scanning transmission electron microscopy and energy-dispersive X-ray spectroscopy. It was observed that a large number of particles had rebounded upon impact, which was correlated with the degree of substrate melting and the associated time for re-solidification. The remnant splats that adhered to the substrate surface were found to exhibit both mechanical and metallurgical bonding with the substrate. The experimental results were supported by transient finite element based thermal simulation

A comparison of EEG spectral entropy with conventional quantitative EEG at varying depths of sevoflurane anaesthesia

Background and Aim: Recently an electroencephalographic (EEG) spectral entropy module (M-ENTROPY) for an anaesthetic monitor has become commercially available. We compared its performance as an indicator of the state of anaesthesia with that of an older conventional quantitative EEG (QEEG) module (M-EEG) by the same manufacturer (Datex-Ohmeda Division, Instrumentarium Corp., Helsinki, Finland). Methods: There were 40 ASA class I or II subjects, aged between 16-60 years, who underwent elective abdominal surgery. EEG data were collected from the printouts of the respective modules. The data presented here were related to four levels of anaesthesia: Pre-anaesthetic wakefulness (state A), 2% sevoflurane endtidal (ET) concentration after completion of surgery (state B), low ET sevoflurane concentrations (~ 0.5%) just prior to regaining responsiveness (state C), and post-anaesthetic responsiveness (state D). Results: In terms of the prediction probability (Pk statistic), response entropy (RE) and state entropy (SE) produced higher values (0.95-1.0) than the best performing QEEG variable, frontal amplitude (0.86-0.95). Only RE scores did not overlap between states A and B or between B and D. The misclassification of subjects between states C and D was far lower for RE (28%) than for any of the conventional QEEG measures (>90%). Conclusion: In on-line monitoring spectral entropy is superior in distinguishing states of anaesthesia and is also easier to use than conventional QEEG. It is speculated that the artefact rejection strategies accorded spectral entropy might significantly benefit conventional QEEG analysis.Key words: EEG spectral entropy, conventional QEEG, sevoflurane anaesthesiaSouthern African Journal of Anaesthesia & Analgesia Vol. 11 (3) 2005: 89-9

Microstructural evolution and bonding of HVOF sprayed Ni particles on both mild and stainless-steel substrates

In the present study, Ni powder was sprayed onto both mild and stainless-steel substrates using high-velocity oxy-fuel (HVOF) deposition to comparatively analyse the effect of substrate material properties and surface condition on splat formation. A range of microscopy techniques including scanning electron microscopy (SEM), focused ion beam (FIB) microscopy, transmission electron microscopy (TEM), scanning transmission electron microscopy (STEM) and energy dispersive X-ray spectroscopy (EDX) were employed to characterize both the splat morphologies, including their cross-sectional structure, as well as the nature of the splat-substrate interface. It was shown that the majority of the particles reached the substrate surface in a partially melted form owing to the high velocity typical in the HVOF process. Despite some splat splashing observed on the stainless-steel sample, the diffusion profiles, determined by STEM-EDX line scans, revealed evidence of elemental interdiffusion at the splat-substrate interface, suggesting metallurgical bonding in this sample. It was observed that splat morphologies, their frequency of occurrence and splat-substrate bond quality are all greatly affected by the surface condition of the substrate. These microstructural observations were correlated with the thermo-mechanical characteristics of the substrates to explain the mechanisms driving splat formation. Differences in the degree of plastic deformation of the substrates due to particle impact are also discussed

Luminosities of AGB Variables

The prevailing evidence suggests that most large-amplitude AGB variables follow the period luminosity (PL) relation that has been established for Miras in the LMC and galactic globular clusters. Hipparcos observations indicate that most Miras in the solar neighbourhood are consistent with such a relation. There are two groups of stars with luminosities that are apparently greater than the PL relation would predict: (1) in the LMC and SMC there are large amplitude variables, with long periods, P> 420 days, which are probably undergoing hot bottom burning, but which are very clearly more luminous than the PL relation (these are visually bright and are likely to be among the first stars discovered in more distant intermediate age populations); (2) in the solar neighbourhood there are short period, P<235 days, red stars which are probably more luminous than the PL relation. Similar short-period red stars, with high luminosities, have not been identified in the Magellanic Clouds.Comment: 8 pages, 2 figure, to be published in Mass-Losing Pulsating Stars and their Circumstellar Matter, Y. Nakada & M. Honma (eds) Kluwer ASSL serie

Tunable cavity coupling of the zero phonon line of a nitrogen-vacancy defect in diamond

We demonstrate the tunable enhancement of the zero phonon line of a single nitrogen-vacancy color center in diamond at cryogenic temperature. An open cavity fabricated using focused ion beam milling provides mode volumes as small as 1.24 $\mu$m$^3$. In-situ tuning of the cavity resonance is achieved with piezoelectric actuators. At optimal coupling of the full open cavity the signal from individual zero phonon line transitions is enhanced by about a factor of 10 and the overall emission rate of the NV$^-$ center is increased by 40% compared with that measured from the same center in the absence of cavity field confinement. This result is important for the realization of efficient spin-photon interfaces and scalable quantum computing using optically addressable solid state spin qubits.Comment: 11 pages Main Article + 4 pages Supplementary Info Typos fixed from v

Optimisation of Continuous and Pulsed Cooling in Injection Moulding Processes

The concept of pulsed cooling in injection moulding involves cycling the flow of coolant in order that cooling only takes place as and when it is required, as opposed to continuous cooling, where the coolant in run through the channels throughout the entire process. It is claimed that using the pulsed cooling method, with reduced temperature coolants, may reduce cycle times and overall energy consumption for the injection moulding process, when compared with continuous cooling. It is also suggested that this is not at the expense of component integrity since common defects such as warpage, which could come about due to non-uniform cooling of the component, or impedance of flow of the polymer into the mould cavity during injection, do not normally appear. The study described in this paper uses a previously validated numerical model in order to optimise the cooling phase of the injection moulding process, for both continuous and pulsed cooling, in order to assess the advantages and disadvantages of each method, with respect to cycle times. In addition, the optimisations were carried out with a view to improving cycle times experimentally, taking into consideration the findings of the study

Reconstructing kinase network topologies from phosphoproteomics data reveals cancer-associated rewiring

Understanding how oncogenic mutations rewire regulatory-protein networks is important for rationalizing the mechanisms of oncogenesis and for individualizing anticancer treatments. We report a chemical phosphoproteomics method to elucidate the topology of kinase-signaling networks in mammalian cells. We identified >6,000 protein phosphorylation sites that can be used to infer >1,500 kinase–kinase interactions and devised algorithms that can reconstruct kinase network topologies from these phosphoproteomics data. Application of our methods to primary acute myeloid leukemia and breast cancer tumors quantified the relationship between kinase expression and activity, and enabled the identification of hitherto unknown kinase network topologies associated with drug-resistant phenotypes or specific genetic mutations. Using orthogonal methods we validated that PIK3CA wild-type cells adopt MAPK-dependent circuitries in breast cancer cells and that the kinase TTK is important in acute myeloid leukemia. Our phosphoproteomic signatures of network circuitry can identify kinase topologies associated with both phenotypes and genotypes of cancer cells