30 research outputs found
Miniaturized parallel screens to identify chromatographic steps required for recombinant protein purification
Breeding objectives for the Boran breed in Kenya: Model development and application to pasture-based production systems
Growth, reproductive, and productive performance of Begait cattle under different herd management systems in northern Ethiopia
Reduced Ulcerogenic Potential and Antiarthritic Effect of Chitosan–Naproxen Sodium Complexes
Mathematical Modeling of Colloidal Particles Transport in the Medium Treated by Nanofluids: Deep Bed Filtration Approach
A deep bed filtration model has been developed to quantify the effect of nanoparticles (NPs) on mitigating fines migration in porous media. The filtration coefficients representing the total kinetics of particles capture were obtained by fitting the model to the laboratory data. Based on the optimum filtration coefficients, the model was utilized to history match the particle concentration breakthrough profiles observed in twelve core flood tests. In the flooding experiments, the effect of five types of metal oxide NPs, γ-Al2O3, CuO, MgO, , and ZnO, on migrating fines were investigated. In each test, a stable suspension was injected into the already NP-treated core and effluents’ fines concentration was measured based on turbidity analysis. In addition, zeta potential analysis was done to obtain the surface charge (SC) of the NP-treated medium. It was found that the presence of NPs on the medium surface results in SC modification of the bed and as a result, enhances the filter performance. Furthermore, the ionic strength of the nanofluid was recognized as an important parameter which governs the capability of NPs to modify the SC of the bed. The remedial effect of NPs on migrating fines is quantitatively explained by the matched filtration coefficients. The SC of the medium soaked by γ-Al2O3 nanofluid is critically increased; therefore, the matched filtration coefficient is of remarkably high value and as a result, the treated medium tends to adsorb more than 70 % of suspended particles. The predicted particle concentration breakthrough curves well matched with the experimental data.Danial Arab, Peyman Pourafshary, Shahaboddin Ayatollah
Influence of Testing Parameters on In Vitro Tramadol Release from Poloxamer Thermogels using the Immersion Cell Method
Evaluation of powder and tableting properties of chitosan
The aim of this study was to analyze the process of tablet formation and the properties of the resulting tablets for 3 N-deacetylated chitosans, with a degree of deacetylation of 80%, 85%, or 90%. Material properties, such as water content, particle size and morphology, glass transition temperature, and molecular weight were studied. The process of tablet formation was analyzed by 3-D modeling, Heckel analysis, the pressure time function, and energy calculations in combination with elastic recovery dependent on maximum relative density and time. The crushing force and the morphology of the final tablets were analyzed. Chitosans sorb twice as much water as microcrystalline cellulose (MCC), the particle size is comparable to Avicel PH 200, a special type of MCC, the particles look like shells, and the edges are bent. Molecular weight ranges from 80 000 to 210 000 kDa, the glass transition temperature (Tg) was not dependent on molecular weight. The chitosans deform ductilely as MCC; however, plastic deformation with regard to time and also pressure plasticity are higher than for MCC, especially for Chit 85, which has the lowest crystallinity and molecular weight. At high densification, fast elastic decompression is higher. 3-D modeling allowed the most precise analysis. Elastic recovery after tableting is higher than for MCC tablets and continues for some time after tableting. The crushing force of the resulting tablets is high owing to a reversible exceeding of Tg in the amorphous parts of the material. However, the crushing force is lower compared with MCC, since the crystallinity and the Tg of the chitosans are higher than for MCC. In summation, chitosans show plastic deformation during compression combined with high elasticity after tableting. Highly mechanically stable tablets result