Pain, Gain - Mission

We present a short conceptual framework as an opinion piece for considering learning gain based on Biesta’s three domains of educational purpose: qualification, socialisation and subjectification. We invite readers to reflect on the perspectives given in relation to different institutions mission statements around teaching and learning, and consider if the focus on developing methods for measuring learning gain is premature, given the lack of consensus regarding the nature of the learning to be measured

Correcting the chromatic anisometropia of red-green glasses and its effect on stereoaccuracy

Negative effects on stereoaccuracy induced by commonly used red-green filters have been a subject of recent investigation1. This study was designed to determine if correcting, with lenses, the chromatic anisometropia induced by these red-green filters could increase the accuracy of stereopsis. The lens power difference needed to correct the chromatic anisometropia was found to be 0.37°, divided between the two eyes. In the control condition the subjects viewed the Randot Circle Stereotest with only the required polarizing glasses. One of the remaining two test conditions used the polarizers in combination with red-green filters, while for the other condition the chromatic anisometropia from the red-green filters was corrected with appropriate lenses. The amount of light transmitted by the filters was kept constant. The chromatic anisometropia correction over the red-green filters significantly reduced stereopsis errors induced by the red-green filters alone (21%, p \u3c 0.05). However, the correction only partially restored stereopsis to control values. A mild anisometropic correction added to the red-green glasses could help improve stereopsis in most individuals

The Sunyaev-Zel'dovich temperature of the intracluster medium

The relativistic Sunyaev-Zel'dovich (SZ) effect offers a method, independent of X-ray, for measuring the temperature of the intracluster medium (ICM) in the hottest systems. Here, using N-body/hydrodynamic simulations of three galaxy clusters, we compare the two quantities for a non-radiative ICM, and for one that is subject both to radiative cooling and strong energy feedback from galaxies. Our study has yielded two interesting results. Firstly, in all cases, the SZ temperature is hotter than the X-ray temperature and is within ten per cent of the virial temperature of the cluster. Secondly, the mean SZ temperature is less affected by cooling and feedback than the X-ray temperature. Both these results can be explained by the SZ temperature being less sensitive to the distribution of cool gas associated with cluster substructure. A comparison of the SZ and X-ray temperatures (measured for a sample of hot clusters) would therefore yield interesting constraints on the thermodynamic structure of the intracluster gas.Comment: This version accepted for publication in MNRAS following minor revisio

Pseudopeptidic ligands: exploring the self-assembly of isopthaloylbisglycine (H2IBG) and divalent metal ions

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Unravelling the molecular control of calvarial suture fusion in children with craniosynostosis

Craniosynostosis, the premature fusion of calvarial sutures, is a common craniofacial abnormality. Causative mutations in more than 10 genes have been identified, involving fibroblast growth factor, transforming growth factor beta, and Eph/ephrin signalling pathways. Mutations affect each human calvarial suture (coronal, sagittal, metopic, and lambdoid) differently, suggesting different gene expression patterns exist in each human suture. To better understand the molecular control of human suture morphogenesis we used microarray analysis to identify genes differentially expressed during suture fusion in children with craniosynostosis. Expression differences were also analysed between each unfused suture type, between sutures from syndromic and non-syndromic craniosynostosis patients, and between unfused sutures from individuals with and without craniosynostosis.Anna K Coussens, Christopher R Wilkinson, Ian P Hughes, C Phillip Morris, Angela van Daal, Peter J Anderson and Barry C Powel

Patterns of Amygdala Region Pathology in LATE-NC: Subtypes that Differ with Regard to TDP-43 Histopathology, Genetic Risk Factors, and Comorbid Pathologies

Transactive response (TAR) DNA-binding protein 43 kDa (TDP-43) pathology is a hallmark of limbic-predominant agerelated TDP-43 encephalopathy (LATE). The amygdala is afected early in the evolution of LATE neuropathologic change (LATE-NC), and heterogeneity of LATE-NC in amygdala has previously been observed. However, much remains to be learned about how LATE-NC originates and progresses in the brain. To address this, we assessed TDP-43 and other pathologies in the amygdala region of 184 autopsied subjects (median age=85 years), blinded to clinical diagnoses, other neuropathologic diagnoses, and risk genotype information. As previously described, LATE-NC was associated with older age at death, cognitive impairment, and the TMEM106B risk allele. Pathologically, LATE-NC was associated with comorbid hippocampal sclerosis (HS), myelin loss, and vascular disease in white matter (WM). Unbiased hierarchical clustering of TDP-43 inclusion morphologies revealed discernable subtypes of LATE-NC with distinct clinical, genetic, and pathologic associations. The most common patterns were: Pattern 1, with lamina II TDP-43+processes and preinclusion pathology in cortices of the amygdala region, and frequent LATE-NC Stage 3 with HS; Pattern 2, previously described as type-β, with neurofbrillary tangle-like TDP-43 neuronal cytoplasmic inclusions (NCIs), high Alzheimer’s disease neuropathologic change (ADNC), frequent APOE ε4, and usually LATE-NC Stage 2; Pattern 3, with round NCIs and thick neurites in amygdala, younger age at death, and often comorbid Lewy body disease; and Pattern 4 (the most common pattern), with tortuous TDP43 processes in subpial and WM regions, low ADNC, rare HS, and lower dementia probability. TDP-43 pathology with features of patterns 1 and 2 were often comorbid in the same brains. Early and mild TDP-43 pathology was often best described to be localized in the “amygdala region” rather than the amygdala proper. There were also important shared attributes across patterns. For example, all four patterns were associated with the TMEM106B risk allele. Each pattern also demonstrated the potential to progress to higher LATE-NC stages with confuent anatomical and pathological patterns, and to contribute to dementia. Although LATE-NC showed distinct patterns of initiation in amygdala region, there was also apparent shared genetic risk and convergent pathways of clinico-pathological evolution

Accumbens D2-MSN hyperactivity drives antipsychotic-induced behavioral supersensitivity

Antipsychotic-induced dopamine supersensitivity, or behavioral supersensitivity, is a problematic consequence of long-term antipsychotic treatment characterized by the emergence of motor abnormalities, refractory symptoms, and rebound psychosis. The underlying mechanisms are unclear and no approaches exist to prevent or reverse these unwanted effects of antipsychotic treatment. Here we demonstrate that behavioral supersensitivity stems from long-lasting pre, post and perisynaptic plasticity, including insertion of Ca2+-permeable AMPA receptors and loss of D2 receptor-dependent inhibitory postsynaptic currents (IPSCs) in D2 receptor-expressing medium spiny neurons (D2-MSNs) in the nucleus accumbens core (NAcore). The resulting hyperexcitability, prominent in a subpopulation of D2-MSNs (21%), caused locomotor sensitization to cocaine and was associated with behavioral endophenotypes of antipsychotic treatment resistance and substance use disorder, including disrupted extinction learning and augmented cue-induced cocaine-seeking behavior. Chemogenetic restoration of IPSCs in D2-MSNs in the NAcore was sufficient to prevent antipsychotic-induced supersensitivity, pointing to an entirely novel therapeutic direction for overcoming this condition

Reactivity of vanadium oxytrichloride with [beta]-diketones and diesters as precursors for vanadium nitride and carbide

Vanadium(V) oxytrichloride was reacted with 2,4-pentanedione, diethyl malonate, and diethyl succinate under inert conditions, forming compounds: dichloro(oxo)(2,4-pentanedione) vanadium(V) [1], dichloro(oxo)(diethyl malonate) vanadium(IV) [2] and dichloro(oxo)(diethyl succinate) vanadium(IV) [3]. Compounds 1–3 are coordinated to the vanadium centre through the two carbonyl oxygen atoms of the bidentate ligand. It was determined by X-ray crystallography that the structures of the resulting complexes were significantly different, resulting in a monomeric complex (1), a tetrameric ring (2) and a 1D coordination polymer (3). Following the synthesis and isolation of 1–3, they were tested as precursors for vanadium nitride and vanadium carbide by annealing under nitrogen and argon respectively at 1200 °C for 24 h. The resulting materials were characterised by: XRD, EDS, XPS and TEM