4 research outputs found
Factor VII deficiency: a novel missense variant and genotype–phenotype correlation in patients from Southern Italy
Assessment of aPTT-based clot waveform analysis for the detection of haemostatic changes in different types of infections
A therapeutic combination of two small molecule toxin inhibitors provides broad preclinical efficacy against viper snakebite
Epigenetics in cancer stem cells
Compelling evidence have demonstrated that bulk tumors can arise from a unique subset of cells commonly termed “cancer stem cells” that has been proposed to be a strong driving force of tumorigenesis and a key mechanism of therapeutic resistance. Recent advances in epigenomics have illuminated key mechanisms by which epigenetic regulation contribute to cancer progression. In this review, we present a discussion of how deregulation of various epigenetic pathways can contribute to cancer initiation and tumorigenesis, particularly with respect to maintenance and survival of cancer stem cells. This information, together with several promising clinical and preclinical trials of epigenetic modulating drugs, offer new possibilities for targeting cancer stem cells as well as improving cancer therapy overall