Reversible acylation of elastase by gamma-lactam analogues of beta-lactam inhibitors

The reaction of a monocyclic γ-lactam with the serine protease elastase occurs via reversible formation of a hydrolytically labile acyl-enzyme complex; in contrast analogous β-lactam inhibitors irreversibly react to form a relatively stable acyl-enzyme complex

Reversible acylation of elastase by y-lactam analogues of B-lactam inhibitors

The reaction of a monocyclic gamma-lactam with the serine protease elastase occurs via reversible formation of a hydrolytically labile acyl-enzyme complex; in contrast analogous beta-lactam inhibitors irreversibly react to form a relatively stable acyl-enzyme complex. (C) 1997 Elsevier Science Ltd.</p

Reversible acylation of elastase by y-lactam analogues of B-lactam inhibitors

The reaction of a monocyclic gamma-lactam with the serine protease elastase occurs via reversible formation of a hydrolytically labile acyl-enzyme complex; in contrast analogous beta-lactam inhibitors irreversibly react to form a relatively stable acyl-enzyme complex. (C) 1997 Elsevier Science Ltd.</p

Nondermatoscopic Digital Imaging of Pigmented Lesions

Background/aims: Pigmented lesions are often difficult to evaluate clinically. Improvement of diagnostic accuracy by dermatoscopy has attracted much interet. With advanced digital imaging measurement of assymmetry, border irregularity and relative color as well as texture characteristics, lesional depth and changes in lesional area are now possible, the object of this review is to conclude the present status of these techniques and their potential. Conclusions: Digital imaging of pigmented lesions to this date include acquiring and storing of images, quantification of clinical features including asymmetry, and teledermatology with transfer of images. Predicted uses include malignancy evaluation, delineation of depth of invasion and the development of large collections of pigment lesions observations. The field is rapidly expanding. As of 1994, it is unknown what role digital imaging will ultimately play in clinical dermatology