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Not AvailableSelection of gastropod shells as shelter by hermit crabs in controlled experiments would provide useful information on the utility of these shells in nature. In this study, shell size and species preferences of Diogenes alias from the northeastern Arabian Sea were quantified by free choice experiments. Males of D. alias, prefer Indothais lacera and Tibia curta, when choice was given; no differences were found for other demographic groups. All hermit crabs occupied larger shells than the shells they occupied in nature. The best correlation was observed between internal volume, weight, and aperture width of the shell with the size of the hermit crab. This pattern has also been reported for other species (i.e., Clibanarius albidigitus, Calcinus tibicen, and C. obscurus). Furthermore, the present study highlights the importance of optimal resources in a scarce environment.Not Availabl

Efficient identification of unknown groundwater pollution sources using linked simulation-optimization incorporating monitoring location impact factor and frequency factor

This study aims to improve the accuracy of groundwater pollution source identification using concentration measurements from a heuristically designed optimal monitoring network. The designed network is constrained by the maximum number of permissible monitoring locations. The designed monitoring network improves the results of source identification by choosing monitoring locations that reduces the possibility of missing a pollution source, at the same time decreasing the degree of non uniqueness in the set of possible aquifer responses to subjected geo-chemical stresses. The proposed methodology combines the capability of Genetic Programming (GP), and linked simulation-optimization for recreating the flux history of the unknown conservative pollutant sources with limited number of spatiotemporal pollution concentration measurements. The GP models are trained using large number of simulated realizations of the pollutant plumes for varying input flux scenarios. A selected subset of GP models are used to compute the impact factor and frequency factor of pollutant source fluxes, at candidate monitoring locations, which in turn is used to find the best monitoring locations. The potential application of the developed methodology is demonstrated by evaluating its performance for an illustrative study area. These performance evaluation results show the efficiency in source identification when concentration measurements from the designed monitoring network are utilized

Co-Processed Excipients for Dispersible Tablets–Part 1: Manufacturability

Co-processed excipients may enhance functionality and reduce drawbacks of traditional excipients for the manufacture of tablets on a commercial scale. The following study aimed to characterise a range of co-processed excipients that may prove suitable for dispersible tablet formulations prepared by direct compression. Co-processed excipients were lubricated and compressed into 10.5-mm convex tablets using a Phoenix compaction simulator. Compression profiles were generated by varying the compression force applied to the formulation and the prepared tablets were characterised for hardness, friability, disintegration and fineness of dispersion. Our data indicates that CombiLac, F-Melt type C and SmartEx QD100 were the top 3 most suitable out of 16 co-processed excipients under the conditions evaluated. They exhibited good flow properties (Carr’s index ˂ 20), excellent tabletability (tensile strength > 3.0 MPa at 0.85 solid fraction), very low friability (< 1% after 15 min), rapid disintegration times (27–49 s) and produced dispersions of ideal fineness (< 250 μm). Other co-processed excipients (including F-Melt type M, Ludiflash, MicroceLac, Pharmaburst 500 and Avicel HFE-102) may be appropriate for dispersible tablets produced by direct compression providing the identified disintegration and dispersion risks were mitigated prior to commercialisation. This indicates that robust dispersible tablets which disintegrate rapidly could be manufactured from a range of co-processed excipients