我国人力资源开发及教育对策研究

人力资源是一切资源中最重要的资源，在知识经济时代，人力资源在经济增长中越来越起到决定性的作用，人力资源开发的成败关系到一个国家未来综合国力及国际竞争实力的强弱。教育是人力资源开发的根本途径，是人力资源开发的核心和关键，教育的规模和质量直接影响到人力资源的数量与质量，关系到一国未来经济发展的潜力。本文的重点是探讨和研究我国人力资源开发与教育的对策。全文共分为四章，主要内容包括： 第一章主要对人力资源开发的理论基础进行概述。全章分为两节。第一节介绍舒尔茨的人力资本理论。本节重点介绍：人力资本与物质资本的涵义，指明人力资本与物质资本的区别；人力资本在经济发展中的地位和作用；人力资本投资内涵；人力资...学位：工商管理硕士院系专业：管理学院工商管理教育中心_工商管理硕士(MBA)学号：19971510

Holographic flows in non-Abelian T-dual geometries

We use non-Abelian T-duality to construct new N=1 solutions of type IIA supergravity (and their M-theory lifts) that interpolate between AdS_5 geometries. We initiate a study of the holographic interpretation of these backgrounds as RG flows between conformal fixed points. Along the way we give an elegant formulation of non-Abelian T-duality when acting on a wide class of backgrounds, including those corresponding to such flows, in terms of their SU(2) structure

Correlates of protection against symptomatic and asymptomatic SARS-CoV-2 infection

The global supply of COVID-19 vaccines remains limited. An understanding of the immune response that is predictive of protection could facilitate rapid licensure of new vaccines. Data from a randomized efficacy trial of the ChAdOx1 nCoV-19 (AZD1222) vaccine in the United Kingdom was analyzed to determine the antibody levels associated with protection against SARS-CoV-2. Binding and neutralizing antibodies at 28 days after the second dose were measured in infected and noninfected vaccine recipients. Higher levels of all immune markers were correlated with a reduced risk of symptomatic infection. A vaccine efficacy of 80% against symptomatic infection with majority Alpha (B.1.1.7) variant of SARS-CoV-2 was achieved with 264 (95% CI: 108, 806) binding antibody units (BAU)/ml: and 506 (95% CI: 135, not computed (beyond data range) (NC)) BAU/ml for anti-spike and anti-RBD antibodies, and 26 (95% CI: NC, NC) international unit (IU)/ml and 247 (95% CI: 101, NC) normalized neutralization titers (NF50) for pseudovirus and live-virus neutralization, respectively. Immune markers were not correlated with asymptomatic infections at the 5% significance level. These data can be used to bridge to new populations using validated assays, and allow extrapolation of efficacy estimates to new COVID-19 vaccines

Cellular processes of v-Src transformation revealed by gene profiling of primary cells - Implications for human cancer

<p>Abstract</p> <p>Background</p> <p>Cell transformation by the Src tyrosine kinase is characterized by extensive changes in gene expression. In this study, we took advantage of several strains of the Rous sarcoma virus (RSV) to characterize the patterns of v-Src-dependent gene expression in two different primary cell types, namely chicken embryo fibroblasts (CEF) and chicken neuroretinal (CNR) cells. We identified a common set of v-Src regulated genes and assessed if their expression is associated with disease-free survival using several independent human tumor data sets.</p> <p>Methods</p> <p>CEF and CNR cells were infected with transforming, non-transforming, and temperature sensitive mutants of RSV to identify the patterns of gene expression in response to v-Src-transformation. Microarray analysis was used to measure changes in gene expression and to define a common set of v-Src regulated genes (CSR genes) in CEF and CNR cells. A clustering enrichment regime using the CSR genes and two independent breast tumor data-sets was used to identify a 42-gene aggressive tumor gene signature. The aggressive gene signature was tested for its prognostic value by conducting survival analyses on six additional tumor data sets.</p> <p>Results</p> <p>The analysis of CEF and CNR cells revealed that cell transformation by v-Src alters the expression of 6% of the protein coding genes of the genome. A common set of 175 v-Src regulated genes (CSR genes) was regulated in both CEF and CNR cells. Within the CSR gene set, a group of 42 v-Src inducible genes was associated with reduced disease- and metastasis-free survival in several independent patient cohorts with breast or lung cancer. Gene classes represented within this group include DNA replication, cell cycle, the DNA damage and stress responses, and blood vessel morphogenesis.</p> <p>Conclusion</p> <p>By studying the v-Src-dependent changes in gene expression in two types of primary cells, we identified a set of 42 inducible genes associated with poor prognosis in breast and lung cancer. The identification of these genes provides a set of biomarkers of aggressive tumor behavior and a framework for the study of cancer cells characterized by elevated Src kinase activity.</p

D-branes in λ-deformations

We show that the geometric interpretation of D-branes in WZW models as twisted conjugacy classes persists in the $\lambda$--deformed theory. We obtain such configurations by demanding that a monodromy matrix constructed from the Lax connection of the $\lambda$--deformed theory continues to produce conserved charges in the presence of boundaries. In this way the D-brane configurations obtained correspond to ``integrable'' boundary configurations. We illustrate this with examples based on $SU(2)$ and $SL(2,\mathbb{R})$, and comment on the relation of these D-branes to both non-Abelian T-duality and Poisson-Lie T-duality. We show that the D2 supported by D0 charge in the $\lambda$--deformed theory map, under analytic continuation together with Poisson-Lie T-duality, to D3 branes in the $\eta$-deformation of the principal chiral model

Correlates of protection against symptomatic and asymptomatic SARS-CoV-2 infection

The global supply of COVID-19 vaccines remains limited. An understanding of the immune response that is predictive of protection could facilitate rapid licensure of new vaccines. Data from a randomized efficacy trial of the ChAdOx1 nCoV-19 (AZD1222) vaccine in the United Kingdom was analyzed to determine the antibody levels associated with protection against SARS-CoV-2. Binding and neutralizing antibodies at 28 days after the second dose were measured in infected and noninfected vaccine recipients. Higher levels of all immune markers were correlated with a reduced risk of symptomatic infection. A vaccine efficacy of 80% against symptomatic infection with majority Alpha (B.1.1.7) variant of SARS-CoV-2 was achieved with 264 (95% CI: 108, 806) binding antibody units (BAU)/ml: and 506 (95% CI: 135, not computed (beyond data range) (NC)) BAU/ml for anti-spike and anti-RBD antibodies, and 26 (95% CI: NC, NC) international unit (IU)/ml and 247 (95% CI: 101, NC) normalized neutralization titers (NF50) for pseudovirus and live-virus neutralization, respectively. Immune markers were not correlated with asymptomatic infections at the 5% significance level. These data can be used to bridge to new populations using validated assays, and allow extrapolation of efficacy estimates to new COVID-19 vaccines

Non-Abelian coset string backgrounds from asymptotic and initial data

We describe hierarchies of exact string backgrounds obtained as non-Abelian cosets of orthogonal groups and having a space--time realization in terms of gauged WZW models. For each member in these hierarchies, the target-space backgrounds are generated by the ``boundary'' backgrounds of the next member. We explicitly demonstrate that this property holds to all orders in ____alpha'. It is a consequence of the existence of an integrable marginal operator build on, generically, non-Abelian parafermion bilinears. These are dressed with the dilaton supported by the extra radial dimension, whose asymptotic value defines the boundary. Depending on the hierarchy, this boundary can be time-like or space-like with, in the latter case, potential cosmological applications

NS5-branes on an ellipsis and novel marginal deformations with parafermions

We consider NS5-branes distributed along the circumference of an ellipsis and explicitly construct the corresponding gravitational background. This provides a continuous line of deformations between the limiting cases, considered before, in which the ellipsis degenerates into a circle or into a bar. We show that a slight deformation of the background corresponding to a circle distribution into an ellipsoidal one is described by a novel non-factorizable marginal perturbation of bilinears of dressed parafermions. The latter are naturally defined for the circle case since, as it was shown in the past, the background corresponds to an orbifold of the exact conformal field theory coset model SU(2)/U(1) times SL(2,R)/U(1). We explore the possibility to define parafermionic objects at generic points of the ellipsoidal families of backgrounds away from the circle point. We also discuss a new limiting case in which the ellipsis degenerates into two infinitely stretched parallel bars and show that the background is related to the Eguchi-Hanson metric, via T-duality

Supersymmetric deformations of F1-NS5-branes and their exact CFT description

We consider certain classes of operators in the exact conformal field theory SL(2,R) x SU(2) x U(1)^4 describing strings in an AdS(3) x S(3) x T4 geometry supported by Neveu--Schwarz 3-form fluxes. This background arises in the near-horizon limit of a system of NS5-branes wrapped on a 4-torus and F1-branes smeared on the 4-torus when both types of branes are located at the same point in their common transverse space. We find a class of operators that lead to spacetime supersymmetric deformations. It is remarkable that most of these operators are not chiral primary with respect to the N=2 superconformal algebra on the wordsheet. A subset of these worldsheet conformal field theory deformations admits an interpretation either as a geometric deformation of the brane system or as a deformation of the distribution of the F1-branes, viewed as smooth instantons, inside the wrapped NS5-brane worldvolume. The 2-dimensional conformal field theory, however, seems to lack operators corresponding to arbitrary NS5-brane deformations, in contrast to pure NS5-brane systems where all geometric deformations can be accounted for by chiral primary operators