TRANSCOLONOSCOPIC EXTRAPERITONEAL CECOSTOMY - A NEW THERAPEUTIC and TECHNICAL PROPOSAL

ALBERT EINSTEIN HOSP,DEPT ENDOSCOPY,BR-01401 São Paulo,BRAZILWeb of Scienc

Effects of ethanol on energy balance of rats and the inappropriateness of intraperitoneal injection

Energy balance of female rats that were either injected daily with ethanol or received the alcohol by gavage was determined and the results compared with saline animals. Food intake, feces elimination, and body weight were recorded daily. After a 20-day period of treatment the animals were sacrificed and the energy content of the carcasses and feces was determined by bomb calorimetry. the results indicated that ethanol-injected animals underwent an impairment in the energy balance, with losses in body weight and body energy. Also, there was a decrease in metabolizable energy intake. the results of a group of saline rats pair-fed to alcohol-injected rats showed that the impairment of the energy balance was not only a consequence of the decreased energy intake, because the ethanol-fed animals had an energy balance that was worse than the one of the pair-fed rats, even though both had eaten the same amount of food Nevertheless, when alcohol was given by gavage, no alteration in the energy balance parameters was detected. Macroscopic observation of the abdominal cavity showed adherences in the gut of the alcohol-injected animals. It is concluded that the ethanol by itself does not alter the energy balance; however, depending on the route of administration it could indirectly impair the energy balance. Copyright (C) 1996 Elsevier Science Inc.Universidade Federal de São Paulo,ESCOLA PAULISTA MED,DEPT FISIOL,DISCIPLINA FISIOL RENAL & TERMOMETAB,BR-04023900 São Paulo,SP,BRAZILUniversidade Federal de São Paulo,ESCOLA PAULISTA MED,DEPT CIRUGIA,DISCIPLINA TECN OPERAT & CIRURGIA EXPT,BR-04023900 São Paulo,SP,BRAZILUniversidade Federal de São Paulo,ESCOLA PAULISTA MED,DEPT FISIOL,DISCIPLINA FISIOL RENAL & TERMOMETAB,BR-04023900 São Paulo,SP,BRAZILUniversidade Federal de São Paulo,ESCOLA PAULISTA MED,DEPT CIRUGIA,DISCIPLINA TECN OPERAT & CIRURGIA EXPT,BR-04023900 São Paulo,SP,BRAZILWeb of Scienc

Evaluation of the longitudinal musculature of segments of the distal colon interposed following extended jejunum-ileum resection

Several morbid conditions may necessitate extensive intestinal resection, leading to short-bower syndrome. When clinical treatment becomes inefficient, a surgical approach is necessary. Distal colon interposition is one of the viable techniques. the interposition of colon segments between remnants of the small bower improved lifestyle, increased transit time, and diminished diarrhea. the aim of this study is to observe the longitudinal muscular contractions after distal colon interposition. Sixteen male Wistar rats (EPM-1) were submitted to an 80% small bowel resection associated with a partial colectomy of the distal colon immediately after the bifurcation of the middle colic artery followed by a 3-cm isoperistaltic distal colon interposition. After 70 days, the animals were submitted to euthanasia and segments of the jejunum, ileum, remnant colon, and interposed colon were prepared for pharmacological tests. the isometric contractions were measured by a poligraph. After 30 minutes, the dose/effect curves were obtained for both metacholine and barium chloride stimulation through the extraluminal surface (serosa). After this period, we observed a significant increase in the length, diameter, and thickness of the intestinal wall. Regarding the sensibility (pD(2)), no difference was found (interposed colon = 7.21 +/- 0.2; remnant colon = 7.65 +/- 0.1; remnant jejunum 7.46 +/- 0.1, and remnant ileum 7.57 +/- 0.1), even though the animals were submitted to different procedures. in relation to the maximal effect (E-max), the longitudinal muscle contraction responses (interposed colon = 11.79 +/- 0.1; remnant jejunum = 15.42 +/- 0.2; and remnant ileum = 11.48 +/- 0.2) were lower than those of the remnant colon (E-max = 22.42 +/- 0.1). This means that there was a possible adaptation of colonic segments to their new location. (C) 1999 Wiley-Liss, Inc.Universidade Federal de São Paulo, Escola Paulista Med, Dept Surg, Discipline Operat Tech & Expt Surg, São Paulo, BrazilUniversidade Federal de São Paulo, Escola Paulista Med, Dept Surg, Discipline Operat Tech & Expt Surg, São Paulo, BrazilWeb of Scienc