5 research outputs found
Crystal Structure of the PAC1R Extracellular Domain Unifies a Consensus Fold for Hormone Recognition by Class B G-Protein Coupled Receptors
- Author
- A Cauvin
- A Miyata
- AA Pioszak
- AA Pioszak
- AA Pioszak
- AC Karaplis
- AJ McCoy
- Augen Pioszak
- B Ahren
- C Martinez
- C Parthier
- C Parthier
- C Sun
- Chenghai Zhang
- CR Underwood
- CRR Grace
- D Reglodi
- D Spengler
- D Vaudry
- E Potterton
- E ter Haar
- F Jamen
- GM Morris
- GM Morris
- GN Murshudov
- H. Eric Xu
- HC Lam
- K Pal
- Karl-Wilhelm Koch
- KJ Ressler
- Kunchithapadam Swaminathan
- L Buscail
- M Basille
- M Stoffel
- NA Baker
- NM Sherwood
- P Emsley
- P Robberecht
- PE Gottschall
- PK Campard
- PM Sexton
- R Maiti
- RA Laskowski
- S Bailey
- S Cavallaro
- S Runge
- S Runge
- SB Needleman
- Shiva Kumar
- SR Rawlings
- SRJ Hoare
- T Dickinson
- Z Otwinowski
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2010
- Field of study
Pituitary adenylate cyclase activating polypeptide (PACAP) is a member of the PACAP/glucagon family of peptide hormones, which controls many physiological functions in the immune, nervous, endocrine, and muscular systems. It activates adenylate cyclase by binding to its receptor, PAC1R, a member of class B G-protein coupled receptors (GPCR). Crystal structures of a number of Class B GPCR extracellular domains (ECD) bound to their respective peptide hormones have revealed a consensus mechanism of hormone binding. However, the mechanism of how PACAP binds to its receptor remains controversial as an NMR structure of the PAC1R ECD/PACAP complex reveals a different topology of the ECD and a distinct mode of ligand recognition. Here we report a 1.9 Å crystal structure of the PAC1R ECD, which adopts the same fold as commonly observed for other members of Class B GPCR. Binding studies and cell-based assays with alanine-scanned peptides and mutated receptor support a model that PAC1R uses the same conserved fold of Class B GPCR ECD for PACAP binding, thus unifying the consensus mechanism of hormone binding for this family of receptors
Delineating the Factors and Cellular Mechanisms Involved in the Survival of Cerebellar Granule Neurons
- Author
- A Allais
- A Falluel-Morel
- A Falluel-Morel
- A Falluel-Morel
- A Tabuchi
- AM Kenney
- AM Marini
- B Barneda-Zahonero
- B Barneda-Zahonero
- B Monti
- B Monti
- BJ Gonzalez
- C Angley
- C Fernández
- D Chrysis
- D Vaudry
- D Vaudry
- DA Linseman
- E Raoult
- FX Zhang
- H Castel
- H Dudek
- H Hahn
- J Alder
- J Moran
- José Rodríguez-Álvarez
- JY Chang
- KA Wood
- L Journot
- M Basille-Dugay
- M Kokubo
- M Lafon-Cazal
- M Villalba
- M Wiedmann
- N Aubert
- N Dahmane
- PK Campard
- R Balázs
- RD Burgoyne
- S Pons
- S Subramaniam
- S Tanaka
- SL Anne
- SR D’Mello
- SR D’Mello
- SS Zhokhov
- SV Bhave
- TM Miller
- V Sée
- X Xifro
- X Xifró
- X Xifró
- Xavier Xifró
- Y Obara
- YA Mei
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Ethanol-Induced Neurodegeneration: Basic Mechanisms and Therapeutic Approaches
- Author
- A Benraiss
- A Dahchour
- A Haubek
- A Leon
- A Pfefferbaum
- A Pfefferbaum
- A Pfefferbaum
- A Pfefferbaum
- A Tutus
- AA Farooqui
- AC Bowling
- AD Thomson
- AJ Harding
- AJ Roberts
- AJ Scheetz
- B Malinowska
- B Tabakoff
- B Tabakoff
- B Tabakoff
- BA Eldadah
- BF Grant
- BJ Mason
- BJ Song
- BL Chenard
- BR Ryu
- C Behl
- C Harper
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- C Ikonomidou
- CB Johansson
- CG Gross
- CR Goodlett
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- D Beracochea
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- DR Lynch
- DW Choi
- DW Walker
- E Climent
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- E Gould
- EH Sinz
- EL Abel
- EV Sullivan
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- F Berton
- F Doetsch
- F Gardoni
- F Majewski
- F Terro
- F Vaccarino
- FH Gage
- FJ Antonawich
- FT Crews
- FX Zhang
- FX Zhang
- G Cambonie
- G Ekstrom
- G Halliday
- G Kempermann
- G Rammes
- G Schroth
- GJ Lees
- GS Robertson
- H Houi
- H Praag van
- H Song
- HC Becker
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- I Ferrer
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2003
- Field of study
Oestrogen as a neuroprotective hormone
- Author
- A Aranda
- A Ferreira
- A Nadal
- A Paganini-Hill
- A Paganini-Hill
- A Paganini-Hill
- A Schlegel
- AJC Slooter
- B Antonsson
- B Moosmann
- BB Sherwin
- BL Neurgaren
- BS McEwen
- C Behl
- C Behl
- C Behl
- C Donaghue
- C Forsell
- C Kawas
- CA Singer
- CA Singer
- CD Toran-Allerand
- CE Powell
- CE Weaver
- CE Weaver
- CH Wetzel
- Christian Behl
- CJ Pike
- CM Klinge
- CS Woolley
- D Manthey
- D Schubert
- DB Dubal
- DD Murphy
- DE Dluzen
- DJ Selkoe
- DM Lonard
- E Barrett-Connor
- E Enmark
- E Gould
- E Kuppers
- E Vegeto
- EV Jensen
- F Sohrabji
- G Gudino-Cabrera
- G Setalo
- GG Kuiper
- GGJM Kuiper
- GK Gouras
- GL Greene
- H Fillit
- H Payami
- H Vedder
- H Zheng
- HA Cameron
- HB Xin
- HS Chae
- HX Xu
- I Azcoitia
- I Azcoitia
- IS Nethrapalli
- J Bishop
- J Shi
- JF Couse
- JJ Watters
- JM Hall
- K Honda
- K Pettersson
- K Sugioka
- KA Hossmann
- KL Chambliss
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- MX Tang
- N Vasudevan
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- P Cohen
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- PJ Shughrue
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- R Rupprecht
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- S Belcredito
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- S Nolen-Hoeksema
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- S Takahashi
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- SH Yang
- SM Belcher
- T Finkel
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- T Ikezu
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- T Okamoto
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- TA Ishunina
- TE Freyaldenhoven
- TM Saleh
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- Y Sagara
- Y Zhang
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2001
- Field of study