10 research outputs found

    Drug transporters: recent advances concerning BCRP and tyrosine kinase inhibitors

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    Multidrug resistance is often associated with the (over)expression of drug efflux transporters of the ATP-binding cassette (ABC) protein family. This minireview discusses the role of one selected ABC-transporter family member, the breast cancer resistance protein (BCRP/ABCG2), in the (pre)clinical efficacy of novel experimental anticancer drugs, in particular tyrosine kinase inhibitors

    ABC Transporters in Multi-Drug Resistance and ADME-Tox of Small Molecule Tyrosine Kinase Inhibitors

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    Structure and function of BCRP, a broad specificity transporter of xenobiotics and endobiotics

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    Corporate distress and turnaround: integrating the literature and directing future research

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