209 research outputs found
Leisure and innovation: exploring boundaries
Innovation has been widely debated in various fields. However, except for leisure innovation in ageing and digital leisure, scant research has been done on the relationship between leisure and innovation. This article presents an overview of the field by mapping out the areas of innovation and leisure, suggesting also a taxonomy for innovations in leisure. Considering both supply and demand perspectives, a roadmap for future leisure and innovation research condensed into 10 priority areas is proposed
Balanços energéticos agropecuários: uma importante ferramenta como indicativo de sustentabilidade de agroecossistemas.
No Brasil, pouca atenção se tem dado às formas e caminhos com que os fluxos energéticos se distribuem nos sistemas produtivos. Na agropecuária, a atenção tem sido voltada a novas fontes de energia (biomassa) ou em tecnologia alternativa, visando a racionalização do uso de energia fóssil ou elétrica. Entretanto, a agricultura tem se desenvolvido baseada fortemente na utilização intensiva de máquinas agrícolas, com conseqüente uso de combustíveis fósseis. Um fator de estrangulamento muito forte no consumo energético geral tem sido a utilização massiva de fertilizantes derivados do petróleo nos agroecossistemas. Estudos de Balanços Energéticos visam determinar os pontos de estrangulamento energético fundamentando a busca por tecnologias poupadoras de energia, especialmente aquelas de origem fóssil (combustível, fertilizante, agrotóxicos, energia despendida na fabricação das máquinas e implementos, etc.). No Brasil, a Região Sul, é onde se encontram vários trabalhos buscando uma agricultura mais auto-sustentável, do ponto de vista da utilização da energia. Em vista da possibilidade de eventuais futuras crises energéticas, o presente trabalho procura analisar o estado-da-arte dos estudos em Balanço Energético, no Brasil e no Mundo, como uma ferramenta de indicação da sustentabilidade dos sistemas agropecuários
Upregulation of Haploinsufficient Gene Expression in the Brain by Targeting a Long Non-coding RNA Improves Seizure Phenotype in a Model of Dravet Syndrome
AbstractDravet syndrome is a devastating genetic brain disorder caused by heterozygous loss-of-function mutation in the voltage-gated sodium channel gene SCN1A. There are currently no treatments, but the upregulation of SCN1A healthy allele represents an appealing therapeutic strategy. In this study we identified a novel, evolutionary conserved mechanism controlling the expression of SCN1A that is mediated by an antisense non-coding RNA (SCN1ANAT). Using oligonucleotide-based compounds (AntagoNATs) targeting SCN1ANAT we were able to induce specific upregulation of SCN1A both in vitro and in vivo, in the brain of Dravet knock-in mouse model and a non-human primate. AntagoNAT-mediated upregulation of Scn1a in postnatal Dravet mice led to significant improvements in seizure phenotype and excitability of hippocampal interneurons. These results further elucidate the pathophysiology of Dravet syndrome and outline a possible new approach for the treatment of this and other genetic disorders with similar etiology
Can induced gravity isotropize Bianchi I, V, or IX Universes?
We analyze if Bianchi I, V, and IX models in the Induced Gravity (IG) theory
can evolve to a Friedmann--Roberson--Walker (FRW) expansion due to the
non--minimal coupling of gravity and the scalar field. The analytical results
that we found for the Brans-Dicke (BD) theory are now applied to the IG theory
which has ( being the square ratio of the Higgs to
Planck mass) in a cosmological era in which the IG--potential is not
significant. We find that the isotropization mechanism crucially depends on the
value of . Its smallness also permits inflationary solutions. For the
Bianch V model inflation due to the Higgs potential takes place afterwads, and
subsequently the spontaneous symmetry breaking (SSB) ends with an effective FRW
evolution. The ordinary tests of successful cosmology are well satisfied.Comment: 24 pages, 5 figures, to be published in Phys. Rev. D1
On Physical Equivalence between Nonlinear Gravity Theories
We argue that in a nonlinear gravity theory, which according to well-known
results is dynamically equivalent to a self-gravitating scalar field in General
Relativity, the true physical variables are exactly those which describe the
equivalent general-relativistic model (these variables are known as Einstein
frame). Whenever such variables cannot be defined, there are strong indications
that the original theory is unphysical. We explicitly show how to map, in the
presence of matter, the Jordan frame to the Einstein one and backwards. We
study energetics for asymptotically flat solutions. This is based on the
second-order dynamics obtained, without changing the metric, by the use of a
Helmholtz Lagrangian. We prove for a large class of these Lagrangians that the
ADM energy is positive for solutions close to flat space. The proof of this
Positive Energy Theorem relies on the existence of the Einstein frame, since in
the (Helmholtz--)Jordan frame the Dominant Energy Condition does not hold and
the field variables are unrelated to the total energy of the system.Comment: 37 pp., TO-JLL-P 3/93 Dec 199
Círculos de controle de qualidade: um estudo de caso no Brasil e uma avaliação da experiência francesa
Experimental alternatives for evaluation of progenies and clones in eucalyptus breeding programs
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