BPMNt : a proposal for flexible process tailoring representation in BPMN /

Business Process Model and Notation (BPMN) is a de-facto standard for business process modeling, which focuses on the representation of the process behavior. However, it can also succeed in representing the behavior of software processes, since they are a type of business process. Although BPMN has been extensively used for modeling processes in different domains, its standard specification does not have any mechanism to support users in activities related to process adaptation (tailoring). Moreover, researches extending BPMN are based on complex consolidated models, which hamper the analysis and maintenance of individual variant process models and are not appropriate for application domains in which process variations are difficult to predict, such as in software development processes. Thus, our objective was to provide a BPMN-compliant extension and associated mechanisms for specifying flexible process tailoring on models produced with this language while ensuring the correctness of adapted process models and explicitly capturing change traces. We have focused our research on the domains of Software Process Engineering (SPE) and Business Process Management (BPM). At last, we evaluated the applicability of the proposal for representing realistic tailoring scenarios in both domains.BPMN (Business Process Model and Notation) é um padrão para modelagem de processos de negócio, que tem seu foco na representação do comportamento de processos. No entanto, ele pode também ser usado para representar o comportamento de processos de software, já que eles são um tipo de processo de negócio. Embora BPMN tem sido extensivamente usado para modelar processos em diferentes domínios, sua especificação padrão não possui nenhum mecanismo para apoiar usuários em atividades relacionadas à adaptação de processos. Pesquisas que estendem o padrão são baseadas em modelos complexos, que dificultam a análise e manutenção de modelos variantes, e não são apropriadas para domínios de aplicação onde variações de processo são difíceis de predizer, como em processos de desenvolvimento de software. Assim, nosso objetivo foi fornecer uma extensão para BPMN, chamada BPMNt, e mecanismos de suporte para especificar, de modo flexível, adaptações em processos modelados com esta linguagem. BPMNt deve também garantir a corretude de modelos adaptados e explicitamente capturar rastros de mudanças realizadas. Essa pesquisa teve como foco os domínios de Engenharia de Processos de Software e Gerenciamento de Processos de Negócio. Por fim, nós avaliamos a aplicabilidade da proposta para representar cenários de adaptação reais em ambos os domínios

Ionospheric response to the 2009 sudden stratospheric warming over the equatorial, low, and middle latitudes in the South American sector

The present study investigates the ionospheric total electron content (TEC) and F-layer response in the Southern Hemisphere equatorial, low, and middle latitudes due to major sudden stratospheric warming (SSW) event, which took place during January-February 2009 in the Northern Hemisphere. In this study, using 17 ground-based dual frequency GPS stations and two ionosonde stations spanning latitudes from 2.8°N to 53.8°S, longitudes from 36.7°W to 67.8°W over the South American sector, it is observed that the ionosphere was significantly disturbed by the SSW event from the equator to the midlatitudes. During day of year 26 and 27 at 14:00 UT, the TEC was two times larger than that observed during average quiet days. The vertical TEC at all 17 GPS and two ionosonde stations shows significant deviations lasting for several days after the SSW temperature peak. Using one GPS station located at Rio Grande (53.8°S, 67.8°W, midlatitude South America sector), it is reported for the first time that the midlatitude in the Southern Hemisphere was disturbed by the SSW event in the Northern Hemisphere.Fil: Fagundes, P. R.. Universidade do Vale do Paraíba; BrasilFil: Goncharenko, L. P.. Massachusetts Institute of Technology; Estados UnidosFil: De Abreu, A. J.. Universidade do Vale do Paraíba; BrasilFil: Venkatesh, K.. Universidade do Vale do Paraíba; BrasilFil: Pezzopane, M.. Istituto Nazionale Di Geofisica E Vulcanologia; ItaliaFil: De Jesus, R.. Universidade do Vale do Paraíba; BrasilFil: Gende, Mauricio Alfredo. Universidad Nacional de La Plata. Facultad de Ciencias Astronómicas y Geofísicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Coster, A. J.. Massachusetts Institute of Technology; Estados UnidosFil: Pillat, V. G.. Universidade do Vale do Paraíba; Brasi

Multifractal analysis of vertical total electron content (VTEC) at equatorial region and low latitude, during low solar activity

This paper analyses the multifractal aspects of the GPS data (measured during a period of low solar activity) obtained from two Brazilian stations: Belém (01.3° S, 48.3° W) and São José dos Campos (SJC) (23.2° S, 45.9° W). The results show that the respective geographic sites show important scaling differences as well as similarities when their multifractal signatures for vertical total electron content (VTEC) are compared. The <I>f</I>(&alpha;) spectra have a narrow shape for great scales, which indicates the predominance of deterministic phenomena, such as solar rotation (27 days) over intermittent phenomena. Furthermore, the <I>f</I>(&alpha;) spectra for both sites have a strong multifractality degree at small scales. This strong multifractality degree observed at small scales (1 to 12 h) at both sites is because the ionosphere over Brazil is a non-equilibrium system. The differences found were that Belém presented a stronger multifractality at small scales (1 h to 12 h) compared with SJC, particularly in 2006. The reason for this behaviour may be associated with the location of Belém, near the geomagnetic equator, where at this location the actions of X-rays, ultraviolet, and another wavelength from the Sun are more direct, strong, and constant throughout the whole year. Although the SJC site is near ionospheric equatorial anomaly (IEA) peaks, this interpretation could explain the higher values found for the intermittent parameter μ for Belém compared with SJC. Belém also showed the presence of one or two flattening regions for <I>f</I>(&alpha;) spectra at the same scales mentioned before. These differences and similarities also were interpreted in terms of the IEA content, where this phenomenon is an important source of intermittence due the presence of the VTEC peaks at ±20° geomagnetic latitudes

IRI-2001 model predictions compared with ionospheric data observed at Brazilian low latitude stations

International audienceIn this work, the F-region critical frequency (foF2) and peak height (hmF2) measured by digital ionosondes at two Brazilian low-latitude stations, namely Palmas (10.17° S, 48.20° W, dip ?10.80°) and São José dos Campos (23.20° S, 45.86° W, dip ?38.41°), are compared with the IRI-2001 model predictions. The comparison at the latter station shows quite a reasonable agreement for both parameters. The former station exhibits a better agreement for hmF2 than for foF2. In general, the model generates good results, although some improvements are still necessary to implement in order to obtain better simulations for equatorial ionospheric regions

PROGRAMA GRÁFICO DESENVOLVIDO EM PYTHON PARA ANÁLISE E FILTRAGEM AUTOMÁTICA DA VARIABILIDADE DA FREQUÊNCIA CARDÍACA

  O TRR-Filter é um programa desenvolvido para filtragem de séries temporais de intervalos RR (duração de um batimento cardíaco completo). Este artigo apresenta o processo de reestruturação do programa TRR–Filter para a linguagem Python com a meta de torna-lo portátil entre sistemas operacionais, além de adicionar outras funcionalidades. O TRR-Filter realiza filtragens automáticas de batimentos cardíacos e plota tacogramas com os dados originais e filtrados que foi feito por Dos Santos et al (2016). O programa foi feito com sucesso e está nas fases finais de testagem

SISTEMA DE MONITORAMENTO AUTOMATIZADO

Atualmente existe uma grande necessidade de ter sistemas que auxiliem no monitoramento de ambientes, por exemplo: uma residência; permitindo assim que o usuário possa controlar e ter acesso a tudo que acontece quando o mesmo estiver ausente. Este projeto propõe realizar o desenvolvimento de um sistema de monitoramento automatizado, cujo objetivo é identificar a presença de pessoas e capturar temperaturas de um ambiente. O sistema é composto por um microcontrolador Arduíno, no qual estará acoplado: uma Webcam, sensores de presença e temperatura e um módulo wifi, que possibilitará o envio dos dados capturados ao servidor web. No protótipo desenvolvido foram implantados todos os recursos definidos com base nos requisitos do usuário, dentre os quais podem-se destacar: permitir detectar a presença de pessoas em ambiente, capturar imagens, capturar temperatura em um intervalo de tempo específico e enviar todos os dados para o servidor; permitir que o usuário visualize as informações capturadas através de um site; gerar relatórios e gráficos com as informações capturadas e permitir que o usuário exporte as informações em formato de arquivo.

Multifunctional PLGA nanoparticles combining transferrin-targetability and pH-stimuli sensitivity enhanced doxorubicin intracellular delivery and in vitro antineoplastic activity in MDR tumor cells

Targeted delivery aims to enhance cellular uptake and improve therapeutic outcome with higher disease specificity. The expression of transferrin receptor (TfR) is upregulated on tumor cells, which make the protein Tf and its receptor vastly relevant when applied to targeting strategies. Here, we proposed Tf-decorated pH-sensitive PLGA nanoparticles containing the chemosensitizer poloxamer as a carrier for doxorubicin delivery to tumor cells (Tf-DOX-PLGA-NPs), aiming at alleviating multidrug resistance (MDR). We performed a range of in vitro studies to assess whether targeted NPs have the ability to improve DOX antitumor potential on resistant NCI/ADR-RES cells. All evaluations of the Tf-decorated NPs were performed comparatively to the nontargeted counterparts, aiming to evidence the real role of NP surface functionalization, along with the benefits of pH-sensitivity and poloxamer, in the improvement of antiproliferative activity and reversal of MDR. Tf-DOX-PLGA-NPs induced higher number of apoptotic events and ROS generation, along with cell cycle arrest. Moreover, they were efficiently internalized by NCI/ADR-RES cells, increasing DOX intracellular accumulation, which supports the greater cell killing ability of these targeted NPs with respect to MDR cells. Altogether, these findings supported the effectiveness of the Tf-surface modification of DOX-PLGA-NPs for an improved antiproliferative activity. Therefore, our pH-responsive Tf-inspired NPs are a promising smart drug delivery system to overcome MDR effect at some extent, enhancing the efficacy of DOX antitumor therapy

Ionospheric response to the 2009 sudden stratospheric warming over the equatorial, low, and middle latitudes in the South American sector

The present study investigates the ionospheric total electron content (TEC) and F-layer response in the Southern Hemisphere equatorial, low, and middle latitudes due to major sudden stratospheric warming (SSW) event, which took place during January-February 2009 in the Northern Hemisphere. In this study, using 17 ground-based dual frequency GPS stations and two ionosonde stations spanning latitudes from 2.8°N to 53.8°S, longitudes from 36.7°W to 67.8°W over the South American sector, it is observed that the ionosphere was significantly disturbed by the SSW event from the equator to the midlatitudes. During day of year 26 and 27 at 14:00 UT, the TEC was two times larger than that observed during average quiet days. The vertical TEC at all 17 GPS and two ionosonde stations shows significant deviations lasting for several days after the SSW temperature peak. Using one GPS station located at Rio Grande (53.8°S, 67.8°W, midlatitude South America sector), it is reported for the first time that the midlatitude in the Southern Hemisphere was disturbed by the SSW event in the Northern Hemisphere.Facultad de Ciencias Astronómicas y Geofísica