Clinical analysis and evaluation of selected laboratory parameters in patients examined in distant periods after trichinellosis

Since early times, opinions of clinicians in distant sequele of the experienced once trichinellosis remain controversial. A set of studies was performed in 75 patients who had experienced trichinellosis 1, 3, 4, 6, or 7 years earlier. Persistence of the general clinical symptoms and of the motor system symptoms as well as persistence of IgG class antibodies against the E/S antigen of Trichinella sp. it was found in 77.3% examined patients. In 84.0% patients bioelectric disturbances (EMG, ENG) were detected. Parasitological studies and pathomorphological examination of muscle biopsies performed in 24 patients pointed to degradation of Trichinella larvae and to the incompletely extinguished pathological process

New aspects of clinical pathology and electro-physiological muscle disturbances in patients with history of trichinellosis

Clinical studies performed in 44 patients, one, three, four, six or seven years after they had experienced trichinellosis demonstrated the persistence of various general and motor ailments in 88.7 % of the patients. The persisting for many years antibodies against E/S antigen of Trichinella in 86.4 % of examined patients seem to reflect chronic stimulation by the larvae which, as shown by parasitological and histopathological tests, survived longer and underwent gradual destruction in muscles. Bio-electric disturbances in muscles were most frequently of a mixed type, with prevalence of a neural type record. These observations illustrate a disturbed function of motor neurones and of impulse transmission at the myoneural junction in patients chronically infected with Trichinella

New aspects of clinical pathology and electro-physiological muscle disturbances in patients with history of trichinellosis

Clinical studies performed in 44 patients, one, three, four, six or seven years after they had experienced trichinellosis demonstrated the persistence of various general and motor ailments in 88.7 % of the patients. The persisting for many years antibodies against E/S antigen of Trichinella in 86.4 % of examined patients seem to reflect chronic stimulation by the larvae which, as shown by parasitological and histopathological tests, survived longer and underwent gradual destruction in muscles. Bio-electric disturbances in muscles were most frequently of a mixed type, with prevalence of a neural type record. These observations illustrate a disturbed function of motor neurones and of impulse transmission at the myoneural junction in patients chronically infected with Trichinella

Detection of Trichinella sp.invasion and clinical appraisal of patients in the late stage of trichinellosis in a new epidemic focus in Wielkopolska

A clinical and an epidemiological analysis was presented of a trichinellosis focus from Wielkopolska region. The studies included 20 persons and trichinellosis was diagnosed in 15 cases. The focus was characterized by asynchronous invasion with Trichinella sp. in individual affected persons in the course of a prolonged period (around 2.5 months) and by reporting of the patients to the Clinic during approximately 30 to 90 days after the disease signs/symptoms developed. Retrospective analysis and a set of specialized tests permitted to clarify causes of persisting complaints, presented by the patients, as well as to establish the diagnosis at late stages of trichinellosis

Clinical appraisal of patients and detection of serum antibodies by ELISA and CIA tests in late periods of

Results of our studies using ELISA and competitive inhibition assay (CIA) tests fully confirmed the previously experienced trichinellosis and reflected persistent stimulation of antibody production due to the antigen release from Trichinella larvae, which had survived longer and undergone gradual destruction in the muscles. The studies proved that the tests complement each other, yielding concordant results in 86.7 % of cases. Due to its higher specificity, the CIA test can help in interpreting pathological signs/symptoms and in evaluating humoral response activity at late and distant in time periods following the invasion

Clinical appraisal of patients and detection of serum antibodies by ELISA and CIA tests in late periods of Trichinella sp. invasion

Results of our studies using ELISA and competitive inhibition assay (CIA) tests fully confirmed the previously experienced trichinellosis and reflected persistent stimulation of antibody production due to the antigen release from Trichinella larvae, which had survived longer and undergone gradual destruction in the muscles. The studies proved that the tests complement each other, yielding concordant results in 86.7 % of cases. Due to its higher specificity, the CIA test can help in interpreting pathological signs/symptoms and in evaluating humoral response activity at late and distant in time periods following the invasion