11 research outputs found
SERUM ELIMINATION HALF-LIFE OF TAMOXIFEN AND ITS METABOLITES IN PATIENTS WITH ADVANCED BREAST-CANCER
THE BIOAVAILABILITY OF TAMOPLEX (TAMOXIFEN) .3. A STEADY-STATE STUDY IN BREAST-CANCER PATIENTS
Serum and urine levels of tamoxifen and its metabolites in patients with advanced breast cancer after a loading dose and at steady-state levels
SERUM ELIMINATION HALF-LIFE OF TAMOXIFEN AND ITS METABOLITES IN PATIENTS WITH ADVANCED BREAST-CANCER
THE BIOAVAILABILITY OF TAMOPLEX (TAMOXIFEN) .3. A STEADY-STATE STUDY IN BREAST-CANCER PATIENTS
NEW INSIGHTS INTO THE TAMOXIFEN PHARMACOKINETICS CONSTITUTE A BASIS FOR A LOADING DOSE SCHEME
NEW INSIGHTS INTO THE TAMOXIFEN PHARMACOKINETICS CONSTITUTE A BASIS FOR A LOADING DOSE SCHEME
Randomised phase III study of biweekly 24-h infusion of high-dose 5FU with folinic acid and oxaliplatin versus monthly plus 5-FU/folinic acid in first-line treatment of advanced colorectal cancer
Background: A phase III study was started to compare oxaliplatin/5FU/LV in the first-line with bolus FU/LV in metastatic colorectal cancer. Patients and methods: 302 patients were randomised and received bolus 5-FU 425 mg/m(2) day 1-5, FA 20 mg/m(2) day 1-5, q 4 wk or oxaliplatin 85 mg/m(2), 2 h-infusion, FA 200 mg/m(2), 1-h infusion. 5-FU 2600 mg/m(2), 24-h infusion day 1, q 2 wk. The primary endpoint was response rate (RR). Results: The median follow-up is 31.8 months, 90.4% of the patients have died. Confirmed RR, progression free survival (PFS; months) and median overall survival (OS; months) in 5FU/LV versus 5FU/LV/oxaliplatin were respectively 18.5% versus (vs) 33.8% (P = 0.004), 5.6 vs 6.7 (P = 0.016) and 13.3 vs 13.8 (P = 0.619). In the 5FU/LV/oxaliplatin arm less grade 3/4 toxicity was measured for diarrhoea, stomatitis, an increase in idiosyncratic side effects and neurosensory events compared with 5FU/LV. The quality of life (QOL) was equal in both arms. Second line treatment was given in 62% of the patients, crossover of 5FU/LV to 5FU/LV/oxaliplatin occurred in 14%. Conclusions: Oxaliplatin in the first-line resulted in an increased RR and PFS with less grade 3/4 mucositis/diarrhoea compared with 5FU/LV alone. Idiosyncratic side effects deserve attention with oxaliplatin. Despite a low treatment cross over rate, OS in both groups was comparable