Small Cofactors May Assist Protein Emergence from RNA World: Clues from RNA-Protein Complexes

It is now widely accepted that at an early stage in the evolution of life an RNA world arose, in which RNAs both served as the genetic material and catalyzed diverse biochemical reactions. Then, proteins have gradually replaced RNAs because of their superior catalytic properties in catalysis over time. Therefore, it is important to investigate how primitive functional proteins emerged from RNA world, which can shed light on the evolutionary pathway of life from RNA world to the modern world. In this work, we proposed that the emergence of most primitive functional proteins are assisted by the early primitive nucleotide cofactors, while only a minority are induced directly by RNAs based on the analysis of RNA-protein complexes. Furthermore, the present findings have significant implication for exploring the composition of primitive RNA, i.e., adenine base as principal building blocks

The deuteron: structure and form factors

A brief review of the history of the discovery of the deuteron in provided. The current status of both experiment and theory for the elastic electron scattering is then presented.Comment: 80 pages, 33 figures, submited to Advances in Nuclear Physic

THERMAL HISTORY, CHEMICAL-COMPOSITION AND RELATIONSHIP OF COMETS TO THE ORIGIN OF LIFE

It is generally believed that a comet consists basically of a loose conglomeration of frozen gases with embedded material similar to that found in the carbonaceous chondritic meteorites, and consequently that comets may be nearly pristine samples of the original solar nebula1−5. We show here that thermal processing within comets could have played an important part in determining their present state; in particular, we find that liquid water might have been available in some comets over geologically and biologically significant spans of time. It follows that a cometary origin is not excluded for some thermally metamorphosed meteorites and asteroids, that comets may contain quite complex organic molecules, and that comets may have played a role in the origin and conceivably even in the subsequent evolution of terrestrial life