12 research outputs found
Improved shear correction factors for deflection of simply supported very thick rectangular auxetic plates
Transfer of the Avoidance Function in Equivalence Classes Using Loss of Points as the Aversive Stimulus
Physiological and Physicochemical Responses of Potato to Selenium Biofortification in Tropical Soil
Radiopacity and cytotoxicity of Portland cement associated with niobium oxide micro and nanoparticles
Increasing Selenium and Yellow Pigment Concentrations in Foxtail Millet (Setaria italica L.) Grain with Foliar Application of Selenite
Reduction of Cd accumulation in Se-biofortified rice by using fermented manure and fly ash
Stem Cell-Based and Tissue Engineering Approaches for Skeletal Muscle Repair
Skeletal muscle tissue exhibits significant regeneration capacity upon injury or disease. This intrinsic regeneration potential is orchestrated by stem cells termed satellite cells, which undergo activation and differentiation in response to muscle insult, giving rise to fusion-competent myogenic progenitors responsible for tissue rejuvenation. Skeletal muscle diseases such as Duchenne muscular dystro-phy are characterized by progressive loss of muscle mass which precipitates reduced motility, paralysis, and in some occurrences untimely death. A manifold of muscle pathologies involve a failure to efficiently regenerate the muscle tissue, rendering stem cell-based approaches an attractive therapeutic strategy. Here we will present past and contemporary methods to treat skeletal muscle degeneration by stem cell therapy, covering prominent challenges facing this technology and potential means to overcome current hurdles. A primary focus of this chapter is directed toward illustrating innovative ways to utilize stem cells alone or in conjunction with biomaterials and tissue engineering techniques to remedy Duchenne muscular dystrophy or volumetric muscle loss