244 research outputs found

    Out-of-hospital cardiac arrest and survival in a patient with Noonan syndrome and multiple lentigines: a case report

    Get PDF
    BACKGROUND: A 9-year-old Arabic boy attending middle school presented with an out-of-hospital cardiac arrest due to ventricular fibrillation recorded by Holter electrocardiographic monitoring. He had a background history of Noonan syndrome with multiple lentigines (also known as LEOPARD syndrome), a rare condition of autosomal dominant inheritance with approximately 200 cases reported worldwide. CASE PRESENTATION: Apart from characteristic features, the boy was known to have asymmetric septal hypertrophy with a maximum wall thickness of 24 mm measured by cardiovascular magnetic resonance imaging. A day prior to the event, he attended cardiology follow-up at our institution, and Holter monitoring was commenced. Following cardiopulmonary resuscitation by bystanders and paramedics, he reverted back into sinus rhythm after a total downtime of 24 min. He was initially treated in the intensive care unit and underwent implantable cardioverter defibrillator implantation. He has made a full recovery and remains at the top of his class. CONCLUSION: This case demonstrates that sudden cardiac arrest in patients with secondary forms of hypertrophic cardiomyopathy is not necessarily protected by apparently favorable phenotypes and that events may be preceded by non-sustained ventricular tachycardia observed by Holter monitoring. Implantable cardioverter defibrillator implantation plays a critical role in both primary and secondary prevention in patients at high risk of out-of-hospital cardiac arrest

    Geomorphological insight into changing tectonic regime, Pasinler Basin, Turkey

    Get PDF
    The Pasinler Basin, in the East Anatolian Contractional Province, features a suite of geomorphological zones, visible in the field, air photographs and Landsat and SRTM DEM imagery. These zones reflect past and current tectonically influenced processes. Collins et al: Geomorphological insight into changing tectonic regime, Pasinler Basin, Turkey. 2 of 26 Remnants of the Erzurum-Kars plateau representing Mio-Pliocene volcanism, associated with transtensional tectonics, have been modified by two stages of drainage development: an earlier, shallow valley network, which was modified following uplift and tilting to form the present system characterised by deep narrow valleys that supply alluvial fan complexes. These fans discharge onto the present, aggradation-dominated basin floor. Initial normal faulting induced massive slope failures on the basin’s northern margin. This extensional phase within the basin was reversed by the Late Pleistocene, with thrust faults modifying and producing landforms, and affecting sediment sequences, along both the north and south basin margins. The shift from a transtensional regime and associated volcanism to normal faulting in the Pliocene-Early Pleistocene, and then to the present compression-dominated regime appears to correspond with regional tectonic changes resulting from collision of the Arabian microplate and the subsequent westward movement of the Anatolian microplate
    corecore