17 research outputs found
Efficacy and Tolerability of Aprepitant for the Prevention of Chemotherapy-Induced Nausea and Vomiting in Patients With Breast Cancer After Moderately Emetogenic Chemotherapy
PURPOSE: This is the first study in which the NK(1)-receptor antagonist, aprepitant (APR), was evaluated for the prevention of chemotherapy-induced nausea and vomiting (CINV) with moderately emetogenic chemotherapy. PATIENTS AND METHODS: Eligible breast cancer patients were naive to emetogenic chemotherapy and treated with cyclophosphamide +/- doxorubicin or epirubicin. Patients were randomly assigned to either an aprepitant regimen (day 1, APR 125 mg, ondansetron (OND) 8 mg, and dexamethasone 12 mg before chemotherapy and OND 8 mg 8 hours later; days 2 through 3, APR 80 qd) [DOSAGE ERROR CORRECTED] or a control regimen (day 1, OND 8 mg and dexamethasone 20 mg before chemotherapy and OND 8 mg 8 hours later; days 2 through 3, OND 8 mg bid). Data on nausea, vomiting, and use of rescue medication were collected with a self-report diary. The primary efficacy end point was the proportion of patients with complete response, defined as no vomiting and no use of rescue therapy, during 120 hours after initiation of chemotherapy in cycle 1. The secondary end point was the proportion of patients with an average item score higher than 6 of 7 on the Functional Living Index-Emesis questionnaire. RESULTS: Of 866 patients randomized, 857 patients (99%) were assessable. Overall complete response was greater with the aprepitant regimen than with the control regimen (50.8% v 42.5%; P = .015). More patients in the aprepitant group reported minimal or no impact of CINV on daily life (63.5% v 55.6%; P = .019). Both treatments were generally well tolerated. CONCLUSION: The aprepitant regimen was more effective than the control regimen for prevention of CINV in patients receiving both an anthracycline and cyclophosphamide.published_or_final_versio
Biomarkers of a five-domain translational substrate for schizophrenia and schizoaffective psychosis
Recovery of bovine lysozyme from transgenic sugarcane stalks: extraction, membrane filtration, and purification
The natural expression of individual differences in self-reported level of response to alcohol during ecologically assessed drinking episodes
New olefin block copolymers of ethylene/1-hexene synthesized by iron and zirconocene catalysts in the presence of ZnEt2
Controllable preparation of branched polyethylene with different microstructures via chain transfer ethylene polymerization catalyzed by α-diimine Ni complex/methylaluminoxane/diethylzinc
The Influence of Purpose in Life on Alcohol Self-Regulation Failure Among Male Inpatients with Alcohol Use Disorder: the Mediation Effects of Self-Control and Abstinence Self-Efficacy
Gravity orientation in social wasp comb cells (Vespinae) and the possible role of embedded minerals
The Materials Super Highway: Integrating High-Throughput Experimentation into Mapping the Catalysis Materials Genome
Tacticity, Regio and Stereoregularity
This chapter focus on the polypropylene tacticity. The stereoregularity and regioregularity of the processes catalyzed by heterogeneous and homogeneous Ziegler-Natta catalysts are discussed. The amazing variety of molecular architectures available for polypropylene-based materials are summarized together with the catalytic mechanisms for tacticity control. The main techniques applied for the determination of PP tacticity are reported as well as the outstanding development of new catalyst systems able to achieve unprecedented PP microstructures