21 research outputs found
Preliminary study towards a novel experimental model to study localized cutaneous leishmaniasis caused bY Leishmania (Leishmania) mexicana
Full text linkHigh mobility group box 1 levels in large vessel vasculitis are not associated with disease activity but are influenced by age and statins
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Rare intronic variants of TCF7L2 arising by selective sweeps in an indigenous population from Mexico
Full text linkBiological invasion of European tomato crops by Tuta absoluta: ecology, geographic expansion and prospects for biological control
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Kinetics of the biphasic liquid–liquid transesterification of vegetable oils into biodiesel
No full textFreshwater input and ocean connectivity affect habitats and trophic ecology of fishes in Arctic coastal lagoons
No full textA multicenter study confirms CD226
Get PDFJournal Article; Multicenter Study; Research Support, Non-U.S. Gov't;INTRODUCTION
CD226 genetic variants have been associated with a number of autoimmune diseases and recently with systemic sclerosis (SSc). The aim of this study was to test the influence of CD226 loci in SSc susceptibility, clinical phenotypes and autoantibody status in a large multicenter European population.
METHODS
A total of seven European populations of Caucasian ancestry were included, comprising 2,131 patients with SSc and 3,966 healthy controls. Three CD226 single nucleotide polymorphisms (SNPs), rs763361, rs3479968 and rs727088, were genotyped using Taqman 5'allelic discrimination assays.
RESULTS
Pooled analyses showed no evidence of association of the three SNPs, neither with the global disease nor with the analyzed subphenotypes. However, haplotype block analysis revealed a significant association for the TCG haplotype (SNP order: rs763361, rs34794968, rs727088) with lung fibrosis positive patients (PBonf = 3.18E-02 OR 1.27 (1.05 to 1.54)).
CONCLUSION
Our data suggest that the tested genetic variants do not individually influence SSc susceptibility but a CD226 three-variant haplotype is related with genetic predisposition to SSc-related pulmonary fibrosis.This work was supported by the following grants: GENFER from the Spanish Society of Rheumatology, SAF2009-11110 from the Spanish Ministry of Science, CTS-4977 from Junta de AndalucĂa, Spain, in part by Redes Temáticas de InvestigaciĂłn Cooperativa Sanitaria Program, RD08/0075 (RIER) from Instituto de Salud Carlos III (ISCIII), Spain and by Fondo Europeo de Desarrollo Regional (FEDER). The VIDI laureate from the Dutch Association of Research (NWO) and Dutch Arthritis Foundation (National Reumafonds). The Orphan Disease Program grant from the European League Against Rheumatism (EULAR). The Dutch Diabetes Research Foundation (grant 2008.40.001) and the Dutch Arthritis Foundation (Reumafonds, grant NR 09-1-408). DFG WI 1031/6.1. This study was also funded by PI-0590-2010, ConsejerĂa de Salud, Junta de AndalucĂa, Spain.Ye
Accuracy of optical biometry combined with Placido disc corneal topography for intraocular lens power calculation
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