Formulation and Evaluation of Prulifloxacin Sustained Release Matrix Tablets

Prulifloxacin is a chemotherapeutic antibiotic of Fluor quinolone drug used to treat a various urinary tract infections. It has short half-life, makes the sustained release (SR) forms extremely advantageous. Sustained release tablets results in increased bioavailability. The purpose of the present study was to develop a sustain release matrix drug delivery system (SR) containing Prulifloxacin as a model drug by using various proportions of polymers such as HPMC E15, HPMC K15. The sustained release formulations of Prulifloxacin were prepared by direct compression method. Optimization of formulation was done by studying effect of drug to polymer ratio on drug release. FT-IR studies indicated absence of any interaction between Prulifloxacin, polymers (HPMC E15 and HPMC K15) and excipients. Ten formulations were prepared and Formulation F8 possesses good drug release property. The tablets were also evaluated for its hardness, friability and other In-vitro evaluation tests. All parameters complied with IP limits. Drug release was diffusion controlled and followed Zero order kinetics. Non-Fickian diffusion was the drug release mechanism for all the tablets formulated. Keywords: Sustained drug delivery system, Prulifloxacin, HPMCE15, HPMCK1

Formulation, evaluation & comparison of traditional poly herbal shampoo powders with marketed formulation

The aim of present work is to formulate poly herbal powder by using different natural herbs like Aswagandha, Tulsi, Ginger, Hibiscus, Aloe vera, Amla and Soap nut to have safety and effectiveness which can avoid toxic effects by chemical ingredients and prepared formulations were compared with marketed poly herbal shampoo. Prepared formulation strengths hair growth, prevents hair fall, dandruff and also acts as antibacterial conditioner and foaming agent without affecting or damaging hair. All the herbs have been selected to formulate poly herbal traditional shampoo powder on the basis of traditional system with scientific modern uses of poly herbs. In this present work herbs like Aswagandha, Tulsi, Ginger, Hibiscus, Aloe vera, Amla and Soap nut were collected, dried, powdered and sieved by passing through sieve no.60, stored in an air tight container and used for further formulation. Then the powders were formulated into four different formulations namely F1, F2, F3, F4 and evaluated for their organoleptic properties like color, odor and texture etc., General powder characteristics like angle of repose, bulk density and true density etc. and physiochemical properties like pH, moisture content, total ash contents, acid insoluble ash, other parameters evaluated were dirt dispersion and foaming capacity. All the four formulations offered good results in all the evaluation tests. The organoleptic characteristics were found to be good, general powder characteristics results were in specified limits and physicochemical evaluation like pH, foaming action, Dirt dispersion were found to yield good satisfactory results. So, the present work successfully formulated poly herbal traditional shampoo powder which meets the modern uses of hair without causing any damage to both skin and hair. Further the Scope of work need to be extended to carry out the stability studies.  Keywords: Poly herbal, Traditiona