Viabilidade de Bifidobacterium animalis (Bb12) em sorvete dietético potencialmente simbiótico de leite cabra, sabor chocolate.

Resumo: O consumo de alimentos funcionais como os probióticos e prebióticos, que ajudam no equilíbrio da microbiota intestinal, pode contribuir de forma relevante para a promoção da saúde. Em virtude da crescente prevalência da diabetes mellitus, o desenvolvimento de um sorvete dietético que permita a adição de prebióticos que possam promover um baixo índice glicêmico, ainda agregado de produtos regionais como o leite de cabras, é promissor. O objetivo deste trabalho foi avaliar a viabilidade do Bifidobacterium animalis (Bb12) em duas formulações de sorvete dietético de leite de cabras potencialmente simbióticos e verificar se houve alteração do pH durante o armazenamento. A viabilidade do probiótico e o pH foram avaliados aos 1, 28 e 56 dias após o processamento do sorvete adicionado com frutooligossacarídeos (FOS) e do sorvete adicionado de inulina, através de contagens em meio MSR-LP. A população de B. animalis nos sorvetes manteve-se superior a 8 log UFC/g durante todo o período de estocagem estudado e o pH de ambos sorvetes manteve-se em torno de 6,0. Os sorvetes desenvolvidos mostraram-se bons veículos para a Bb12, atendendo à legislação brasileira para produtos probióticos

High scale impact in alignment and decoupling in two-Higgs doublet models

The two-Higgs doublet model (2HDM) provides an excellent benchmark to study physics beyond the Standard Model (SM). In this work we discuss how the behaviour of the model at high energy scales causes it to have a scalar with properties very similar to those of the SM -- which means the 2HDM can be seen to naturally favor a decoupling or alignment limit. For a type II 2HDM, we show that requiring the model to be theoretically valid up to a scale of 1 TeV, by studying the renormalization group equations (RGE) of the parameters of the model, causes a significant reduction in the allowed magnitude of the quartic couplings. This, combined with $B$-physics bounds, forces the model to be naturally decoupled. As a consequence, any non-decoupling limits in type II, like the wrong-sign scenario, are excluded. On the contrary, even with the very constraining limits for the Higgs couplings from the LHC, the type I model can deviate substantially from alignment. An RGE analysis similar to that made for type II shows, however, that requiring a single scalar to be heavier than about 500 GeV would be sufficient for the model to be decoupled. Finally, we show that not only a 2HDM where the lightest of the CP-even scalars is the 125 GeV one does not require new physics to be stable up to the Planck scale but this is also true when the heavy CP-even Higgs is the 125 GeV and the theory has no decoupling limit for the type I model.Comment: 28 pages, 19 figure

Implementing Information Management Strategically: An Australian EDRMS Case Study

Organisations in both private and public sectors are increasingly becoming aware of the need to take a strategic approach to the management of corporate information and records. In this paper we present a case study of a successful Electronic Document and Records Management System (EDRMS) implementation within a major Australian capital city council. Guided by Ward and Peppard’s strategic systems framework (2002), the case study highlights a set of strategies which were responsible for the successful outcome of the implementation – and shows just how crucial it is for any organisation to bring with it the people and the processes involved in the creation, management and maintenance of records and information, if a centralised approach is to work over the longer term

Processamento de creme de leite de cabra padronizado pasteurizado.

bitstream/item/58376/1/COT-124.pd

Quantum Correlations in Multipartite Quantum Systems

We review some concepts and properties of quantum correlations, in particular multipartite measures, geometric measures and monogamy relations. We also discuss the relation between classical and total correlationsComment: to be published as a chapter of the book "Lectures on general quantum correlations and their applications" edited by F. Fanchini, D. Soares-Pinto, and G. Adesso (Springer, 2017

Mitochondrial DNA Copy Numbers in Pyramidal Neurons are Decreased and Mitochondrial Biogenesis Transcriptome Signaling is Disrupted in Alzheimer’s Disease Hippocampi

Alzheimer\u27s disease (AD) is the major cause of adult-onset dementia and is characterized in its pre-diagnostic stage by reduced cerebral cortical glucose metabolism and in later stages by reduced cortical oxygen uptake, implying reduced mitochondrial respiration. Using quantitative PCR we determined the mitochondrial DNA (mtDNA) gene copy numbers from multiple groups of 15 or 20 pyramidal neurons, GFAP(+) astrocytes and dentate granule neurons isolated using laser capture microdissection, and the relative expression of mitochondrial biogenesis (mitobiogenesis) genes in hippocampi from 10 AD and 9 control (CTL) cases. AD pyramidal but not dentate granule neurons had significantly reduced mtDNA copy numbers compared to CTL neurons. Pyramidal neuron mtDNA copy numbers in CTL, but not AD, positively correlated with cDNA levels of multiple mitobiogenesis genes. In CTL, but not in AD, hippocampal cDNA levels of PGC1α were positively correlated with multiple downstream mitobiogenesis factors. Mitochondrial DNA copy numbers in pyramidal neurons did not correlate with hippocampal Aβ1-42 levels. After 48 h exposure of H9 human neural stem cells to the neurotoxic fragment Aβ25-35, mtDNA copy numbers were not significantly altered. In summary, AD postmortem hippocampal pyramidal neurons have reduced mtDNA copy numbers. Mitochondrial biogenesis pathway signaling relationships are disrupted in AD, but are mostly preserved in CTL. Our findings implicate complex alterations of mitochondria-host cell relationships in AD

The Vulnerabilities of Orphaned Children Participating in Research: A Critical Review and Factors for Consideration for Participation in Biomedical and Behavioral Research

Orphans are a subpopulation with a unique set of additional vulnerabilities. Increasing focus on children’s rights, pediatric global health, and pediatric research makes it imperative to recognize and address unique vulnerabilities of orphaned children. This paper describes the unique vulnerabilities of the orphaned pediatric population and offers a structured set of factors that require consideration when including orphans in biomedical research. Pediatric orphans are particularly vulnerable due to decreased economic resources, psychosocial instability, increased risk of abuse, and delayed/decreased access to healthcare. These vulnerabilities are significant. By carefully considering each issue in a population in a culturally specific and study-specific manner, researchers can make valuable contributions to the overall health and well-being of this uniquely vulnerable population