15 research outputs found
Intersect-then-combine approach: improving the performance of somatic variant calling in whole exome sequencing data using multiple aligners and callers
Full text linkFOXP3+ regulatory T cells as biomarkers in human malignancies.
No full textBACKGROUND: Regulatory T cells (Treg) expressing the FOXP3 forkhead transcription factor maintain immunological self-tolerance and can enable tumour cells to escape immunosurveillance. OBJECTIVE: To provide an overview of studies using FOXP3 as a biomarker in human malignancies, particularly in the context of the antibodies used to detect FOXP3 protein expression, the cell populations selected for study, and the detection and scoring methodologies used. METHODS: A personal selection of studies analysing FOXP3 as a marker of Treg cells in human malignancies are discussed. RESULTS/CONCLUSION: FOXP3 is a useful marker that can be used in routine clinical practise to provide both diagnostic and prognostic information in human malignancies. However, the methods and reagents used to detect FOXP3 can have a significant effect on the robustness of experimental findings and conclusions
Defense of the clone: antibody 259D effectively labels human FOXP3 in a variety of applications.
No full textGenome-wide haplotype association study identifies BLM as a risk gene for prostate cancer in Chinese population
No full textThe p90 ribosomal S6 kinase 2 specifically affects mitotic progression by regulating the basal level, distribution and stability of mitotic spindles
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Screening and Identification of the Binding Peptides of Mycoplasma genitalium Protein of Adhesion
No full textUpregulation of DACT2 suppresses proliferation and enhances apoptosis of glioma cell via inactivation of YAP signaling pathway
No full textConcomitant activation of ETS-like transcription factor-1 and Death Receptor-5 via extracellular signal-regulated kinase in withaferin A-mediated inhibition of hepatocarcinogenesis in mice
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