905 research outputs found
Perceived support for innovation and individual innovation readiness as mediators between transformational leadership and innovative work behaviour
While transformational leadership is often seen to induce innovative work behaviour of employees, little is known about the psychological mechanisms through which this effect occurs. This research conceptualises the mediating effect of perceived support for innovation and individual innovation readiness in a series between transformational leadership on innovative work behaviour. We use the responses of 428 employees from six service organisations in Singapore to test our three-path mediation model. As hypothesised, the data supported the three-path mediation model. Results revealed a partial mediating role of support for innovation and a fully mediating role of individual innovation readiness. This finding is useful for designing and implementing effective human resource and organisational development interventions, with the objective of facilitating innovation in the workforce
Support for innovation and individual innovation readiness as mediators between transformational leadership and innovative work behaviour:An empirical study within Singaporean service organizations
Changes in the world’s economic landscape is forcing companies, especially those in the service industry, to stay relevant by introducing innovative service options and solutions. Employee innovative behavior has become an important condition for these businesses to succeed in this dynamic environment. While transformational leadership is often seen to induce innovative work behavior in employees, little is known about the psychological mechanisms through which this effect occurs. Our research conceptualizes the mediating effect of perceived support for innovation and individual innovation readiness in a series: between transformational leadership and actual innovative work behavior. We use the responses of 428 employees from six service organizations in Singapore to test our three-path mediation model. As hypothesized, the data supported the three-path mediation model. The results reveal a partial mediating role of support for innovation and a fully mediating role of individual innovation readiness. This finding is useful for designing and implementing effective human resource and organizational development interventions, with the objective of facilitating innovation in workforce within the service-type contexts
Heat and Work Along Individual Trajectories of a Quantum Bit
We use a near quantum limited detector to experimentally track individual quantum state trajectories of a driven qubit formed by the hybridization of a waveguide cavity and a transmon circuit. For each measured quantum coherent trajectory, we separately identify energy changes of the qubit as heat and work, and verify the first law of thermodynamics for an open quantum system. We further establish the consistency of these results by comparison with the master equation approach and the two-projective-measurement scheme, both for open and closed dynamics, with the help of a quantum feedback loop that compensates for the exchanged heat and effectively isolates the qubit
Simulation of Beam-Beam Effects and Tevatron Experience
Effects of electromagnetic interactions of colliding bunches in the Tevatron
had a variety of manifestations in beam dynamics presenting vast opportunities
for development of simulation models and tools. In this paper the computer code
for simulation of weak-strong beam-beam effects in hadron colliders is
described. We report the collider operational experience relevant to beam-beam
interactions, explain major effects limiting the collider performance and
compare results of observations and measurements with simulations.Comment: 23 pages, 17 figure
Dimeric FcγR ectodomains detect pathogenic anti-platelet factor 4-heparin antibodies in heparin-induced thromobocytopenia
Background
Heparin‐induced thrombocytopenia (HIT) is a major and potentially fatal consequence of antibodies produced against platelet factor 4 (PF4)–heparin complexes following heparin exposure. Not all anti‐PF4–heparin antibodies are pathogenic, so overdiagnosis can occur, with resulting inappropriate use of alternative anticoagulation therapies that have associated risks of bleeding. However, definitive platelet functional assays are not widely available for routine analysis.
Objectives
To assess the utility of dimeric recombinant soluble FcγRIIa (rsFcγRIIa) ectodomains for detecting HIT antibodies.
Patients/Methods
Plasma from 27 suspected HIT patients were tested for pathogenic anti‐PF4–heparin antibodies by binding of a novel dimeric FcγRIIa ectodomain probe. Plasmas were also tested by the use of PF4–heparin IgG ELISA, the HemosIL AcuStar HIT IgG‐specific assay, and a serotonin release assay (SRA).
Results
The dimeric rsFcγRIIa test produced no false positives and excluded four samples that were positive by IgG ELISA. In this small patient cohort, the novel assay correctly assigned 93% of the suspected HIT patients, with two of the HIT patients being scored as false negatives. The improved discrimination of the novel assay over the IgG ELISA, which scored four false positives, supports the mechanistic interpretation that binding of dimeric rsFcγRIIa detects pairs of closely spaced IgG antibodies in PF4–heparin immune complexes.
Conclusions
This study found the cell‐free, function‐based dimeric rsFcγRIIa assay to be convenient, simple, and potentially predictive of HIT. The assay had improved specificity over the IgG ELISA, and correlated strongly with the AcuStar HIT IgG‐specific assay, warranting further evaluation of its potential to identify HIT in larger patient cohorts
Models of electron transport in single layer graphene
The main features of the conductivity of doped single layer graphene are
analyzed, and models for different scattering mechanisms are presented.Comment: 15 pages. Submitted to the Proceedings of the ULTI symposium on
Quantum Phenomena and Devices at Low Temperatures, Espoo, Finland, to be
published in the Journ. of Low. Temp. Phy
Comments on: "Starting solutions for some unsteady unidirectional flows of a second grade fluid," [Int. J. Eng. Sci. 43 (2005) 781]
A significant mathematical error is identified and corrected in a recent
highly-cited paper on oscillatory flows of second-grade fluids [Fetecau &
Fetecau (2005). Int. J. Eng. Sci., 43, 781--789]. The corrected solutions are
shown to agree identically with numerical ones generated by a finite-difference
scheme, while the original ones of Fetecau & Fetecau do not. A list of other
recent papers in the literature that commit the error corrected in this Comment
is compiled. Finally, a summary of related erroneous papers in this journal is
presented as an Appendix.Comment: 8 pages, 2 figures (4 images), elsarticle class; accepted for
publication in International Journal of Engineering Scienc
Genetic and bioinformatic analyses of the expression and function of PI3K regulatory subunit PIK3R3 in an Asian patient gastric cancer library
10.1186/1755-8794-5-34BMC Medical Genomics5
Isotopic composition of fragments in multifragmentation of very large nuclear systems: effects of the chemical equilibrium
Studies on the isospin of fragments resulting from the disassembly of highly
excited large thermal-like nuclear emitting sources, formed in the ^{197}Au +
^{197}Au reaction at 35 MeV/nucleon beam energy, are presented. Two different
decay systems (the quasiprojectile formed in midperipheral reactions and the
unique source coming from the incomplete fusion of projectile and target in the
most central collisions) were considered; these emitting sources have the same
initial N/Z ratio and excitation energy (E^* ~= 5--6 MeV/nucleon), but
different size. Their charge yields and isotopic content of the fragments show
different distributions. It is observed that the neutron content of
intermediate mass fragments increases with the size of the source. These
evidences are consistent with chemical equilibrium reached in the systems. This
fact is confirmed by the analysis with the statistical multifragmentation
model.Comment: 9 pages, 4 ps figure
Analysis of acoustic emission during the melting of embedded indium particles in an aluminum matrix: a study of plastic strain accommodation during phase transformation
Acoustic emission is used here to study melting and solidification of
embedded indium particles in the size range of 0.2 to 3 um in diameter and to
show that dislocation generation occurs in the aluminum matrix to accommodate a
2.5% volume change. The volume averaged acoustic energy produced by indium
particle melting is similar to that reported for bainite formation upon
continuous cooling. A mechanism of prismatic loop generation is proposed to
accommodate the volume change and an upper limit to the geometrically necessary
increase in dislocation density is calculated as 4.1 x 10^9 cm^-2 for the
Al-17In alloy. Thermomechanical processing is also used to change the size and
distribution of the indium particles within the aluminum matrix. Dislocation
generation with accompanied acoustic emission occurs when the melting indium
particles are associated with grain boundaries or upon solidification where the
solid-liquid interfaces act as free surfaces to facilitate dislocation
generation. Acoustic emission is not observed for indium particles that require
super heating and exhibit elevated melting temperatures. The acoustic emission
work corroborates previously proposed relaxation mechanisms from prior internal
friction studies and that the superheat observed for melting of these
micron-sized particles is a result of matrix constraint.Comment: Presented at "Atomistic Effects in Migrating Interphase Interfaces -
Recent Progress and Future Study" TMS 201
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