Young ghosts: ethical and methodological issues of historical research in children's geographies

This paper was published in the journal, Children's Geographies [© Taylor & Francis] and the definitive version is available at: http://dx.doi.org/10.1080/14733285.2012.693838Geographers researching children and young people have often been at the forefront of disciplinary debates in geography surrounding methodological practice and ethical considerations (Matthews et al. 1998, Valentine 1999, Pain 2004, Hemming 2008, Hopkins and Bell 2008, van Blerk and Barker 2008). In this short paper, I want to focus on a less-popular research method used by children’s geographers – archival methods (cf. Gagen 2000, 2001) – and reflect specifically on some of its methodological and ethical challenges. I argue that thinking about historical research can challenge children’s geographers to consider other types of encounter from that of the (embodied) encounter between a researcher and a child (Horton 2008). These different and multiple encounters include those between the (adult) creator of ‘material’ and a young person, a young person (as creator) and their intended audience, and the further encounter between a young person from the past and a present-day researcher during fieldwork. The spatial and temporal deferral in some of these encounters suggests a re-thinking of how we approach and conceptualise research ‘with’ young people. Furthermore, these (dis)embodied encounters can challenge ethical norms in children’s geographies such as consent, confidentiality and positionality in different but overlapping ways. I contend that children’s geographers are well versed in these ethical issues, some of which transfer well into the practice of historical research. For example, issues surrounding children’s ‘voice’ and responsibility are quite similar (as I later discuss), but there is a difference between contemporary and historical research in terms of the media involved (your own tape recordings or someone else’s recorded tapes; fresh participatory artwork or dust-covered diaries) and a different retrieval process (direct embodied research with young people or deferred connections in another building, time and place)

Measurements of differential production cross sections for a Z boson in association with jets in pp collisions at root s=8 TeV

Peer reviewe

New insights into the genetic etiology of Alzheimer's disease and related dementias

Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele

A measurement of B(D+S → φl+ν) B(D+S → φπ+)

Using the CLEO II detector at CESR, we have measured the ratio of branching fractions B (D + S → φl + ν) B (D + S → φπ + ) = 0.54 ± 0.05 ± 0.04 . We use this measurement to obtain a model dependent estimate of B (D + S → φπ + )

Repositioning of the global epicentre of non-optimal cholesterol

High blood cholesterol is typically considered a feature of wealthy western countries1,2. However, dietary and behavioural determinants of blood cholesterol are changing rapidly throughout the world3 and countries are using lipid-lowering medications at varying rates. These changes can have distinct effects on the levels of high-density lipoprotein (HDL) cholesterol and non-HDL cholesterol, which have different effects on human health4,5. However, the trends of HDL and non-HDL cholesterol levels over time have not been previously reported in a global analysis. Here we pooled 1,127 population-based studies that measured blood lipids in 102.6 million individuals aged 18 years and older to estimate trends from 1980 to 2018 in mean total, non-HDL and HDL cholesterol levels for 200 countries. Globally, there was little change in total or non-HDL cholesterol from 1980 to 2018. This was a net effect of increases in low- and middle-income countries, especially in east and southeast Asia, and decreases in high-income western countries, especially those in northwestern Europe, and in central and eastern Europe. As a result, countries with the highest level of non-HDL cholesterol—which is a marker of cardiovascular risk—changed from those in western Europe such as Belgium, Finland, Greenland, Iceland, Norway, Sweden, Switzerland and Malta in 1980 to those in Asia and the Pacific, such as Tokelau, Malaysia, The Philippines and Thailand. In 2017, high non-HDL cholesterol was responsible for an estimated 3.9 million (95% credible interval 3.7 million–4.2 million) worldwide deaths, half of which occurred in east, southeast and south Asia. The global repositioning of lipid-related risk, with non-optimal cholesterol shifting from a distinct feature of high-income countries in northwestern Europe, north America and Australasia to one that affects countries in east and southeast Asia and Oceania should motivate the use of population-based policies and personal interventions to improve nutrition and enhance access to treatment throughout the world.</p