Mathematical modelling of the ischaemic heart

Recent advances in high performance computing combined with increasing knowledge of them kinetics of biochemical reactions and transport processes have allowed us to develop mathematical models that describe various aspects of cardiac physiology. These models include both single cell and three-dimensional tissue models that simulate important features of cardiac electrophysiology, mechanics, and metabolism. We have begun to couple these models with the goal of creating a fully integrated cardiac model that can describe the pathophysiology of the ischaemic heart. Here we present an outline of this work

Mathematical modelling of the heart: cell to organ

Single cell and whole organ mathematical models of cardiac electrophysiology, mechanics and metabolism are presented. The important elements of each model are outlined and, in particular, the methods, techniques and considerations for coupling each element together to create an integrated cardiac model are discussed. Results for both individual tissue and whole organ simulations are presented along with preliminary results from coupled models. (C) 2002 Published by Elsevier Science Ltd

Mathematical modelling of the heart: cell to organ

Single cell and whole organ mathematical models of cardiac electrophysiology, mechanics and metabolism are presented. The important elements of each model are outlined and, in particular, the methods, techniques and considerations for coupling each element together to create an integrated cardiac model are discussed. Results for both individual tissue and whole organ simulations are presented along with preliminary results from coupled models. (C) 2002 Published by Elsevier Science Ltd