6 research outputs found

    Neural model of dopaminergic control of arm movements in Parkinson’s disease bradykinesia

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    Patients suffering from Parkinson’s disease display a number of symptoms such a resting tremor, bradykinesia, etc. Bradykinesia is the hallmark and most disabling symptom of Parkinson’s disease (PD). Herein, a basal ganglia-cortico-spinal circuit for the control of voluntary arm movements in PD bradykinesia is extended by incorporating DAergic innervation of cells in the cortical and spinal components of the circuit. The resultant model simulates successfully several of the main reported effects of DA depletion on neuronal, electromyographic and movement parameters of PD bradykinesia

    Multidisciplinary Perspectives for Alzheimer's and Parkinson's Diseases: Hydrogels for Protein Delivery and Cell-Based Drug Delivery as Therapeutic Strategies

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