7 research outputs found
Neural model of dopaminergic control of arm movements in Parkinson’s disease bradykinesia
Patients suffering from Parkinson’s disease display a number of
symptoms such a resting tremor, bradykinesia, etc. Bradykinesia is the hallmark
and most disabling symptom of Parkinson’s disease (PD). Herein, a basal
ganglia-cortico-spinal circuit for the control of voluntary arm movements in PD
bradykinesia is extended by incorporating DAergic innervation of cells in the
cortical and spinal components of the circuit. The resultant model simulates
successfully several of the main reported effects of DA depletion on neuronal,
electromyographic and movement parameters of PD bradykinesia