56 research outputs found
Prevalence of Pediatric Functional Gastrointestinal Disorders Utilizing the Rome IV Criteria
Objective: To assess the prevalence of functional gastrointestinal (GI) disorders in children 0-18 years old according to the newly established Rome IV diagnostic criteria as reported by parents in a representative community sample. Study design: A cross-sectional study in which mothers (n = 1255) of children aged 0-18 years old in the US were recruited to complete an online survey about their child's GI symptoms, quality of life (QoL), and other health conditions. Results: Based on the Rome IV criteria, 24.7% of infants and toddlers aged 0-3 years and 25.0% of children and adolescents aged 4-18 years fulfilled symptom-based criteria for a functional GI disorder. The most common functional GI disorders were infant regurgitation among infants (24.1%) and functional constipation among both toddlers (18.5%) and children and adolescents (14.1%). QoL was diminished in pediatric patients with functional GI disorders (median = 71.69 vs median = 87.60; z = −11.41; P <.001). Children were more likely to qualify for a functional GI disorder if their parent qualified for a functional GI disorder (35.4% vs 23.0%; P <.001). Conclusions: Based on Rome IV criteria, functional GI disorders are common in pediatric populations of all ages and are associated with decreased QoL
Meditation-induced bliss viewed as release from conditioned neural (thought) patterns that block reward signals in the brain pleasure center
The nucleus accumbens orchestrates processes related to reward and pleasure,
including the addictive consequences of repeated reward (e.g., drug addiction and
compulsive gambling) and the accompanying feelings of craving and anhedonia.
The neurotransmitters dopamine and endogenous opiates play interactive roles in
these processes. They are released by natural rewards (i.e., food, water, sex, money,
play, etc.) and are released or mimicked by drugs of abuse. Repeated drug use
induces conditioned down-regulation of these neurotransmitters, thus causing
painful suppression of everyday pleasure. As with many spiritual traditions,
Buddhism provides strong advice against the pursuit of worldly pleasures to
attain the ‘‘good life.’’ In contrast, many forms of meditation give rise to an
immense and abiding joy. Most of these practices involve ‘‘stilling the mind,’’
whereby all content-laden thought (e.g., fantasies, daydreams, plans) ceases, and
the mind enters a state of openness, formlessness, clarity, and bliss. This can be
explained by the Buddhist suggestion that almost all of our everyday thoughts are
a form of addiction. It follows that if we turn off this internal ‘‘gossip of ego,’’ we
will find relief from the biochemical dopamine/opiate down-regulation, which is,
perhaps, the perpetual concomitant of our daily rumination
Meditation-induced bliss viewed as release from conditioned neural (thought) patterns that block reward signals in the brain pleasure center
Chronic Intestinal Pseudo-Obstruction: Pediatric Case Presentations and Review of the Literature
Targeted Delivery of an Antisense Oligonucleotide in the Retina: Uptake, Distribution, Stability, and Effect
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