4 research outputs found
Allopurinol and oxypurinol are hydroxyl radical scavengers
AbstractAllopurinol is a scavenger of the highly reactive hydroxyl radical (k2 approx. 109 M−1s−1). One product of attack of hydroxyl radical upon allopurinol is oxypurinol, which is a major metabolite of allopurinol. Oxypurinol is a better hydroxyl radical scavenger than is allopurinol (k2 approx. 4 × 109 M−1s−1) and it also reacts with the myeloperoxidase-derived oxidant hypochlorous acid. Hence the protective actions of allopurinol against reperfusion damage after hypoxia need not be entirely due to xanthine oxidase inhibition
Evaluating the effects of active morning commutes on students' overall daily walking activity in Singapore: Do walkers walk more?
10.1016/j.jth.2018.01.002Journal of Transport & Health8220-24