694 research outputs found
Simulations of Weighted Tree Automata
Simulations of weighted tree automata (wta) are considered. It is shown how
such simulations can be decomposed into simpler functional and dual functional
simulations also called forward and backward simulations. In addition, it is
shown in several cases (fields, commutative rings, Noetherian semirings,
semiring of natural numbers) that all equivalent wta M and N can be joined by a
finite chain of simulations. More precisely, in all mentioned cases there
exists a single wta that simulates both M and N. Those results immediately
yield decidability of equivalence provided that the semiring is finitely (and
effectively) presented.Comment: 17 pages, 2 figure
Effects of amlodipine and lisinopril on left ventricular mass and diastolic function in previously untreated patients with mild to moderate diastolic hypertension
Punctuated equilibria and 1/f noise in a biological coevolution model with individual-based dynamics
We present a study by linear stability analysis and large-scale Monte Carlo
simulations of a simple model of biological coevolution. Selection is provided
through a reproduction probability that contains quenched, random interspecies
interactions, while genetic variation is provided through a low mutation rate.
Both selection and mutation act on individual organisms. Consistent with some
current theories of macroevolutionary dynamics, the model displays
intermittent, statistically self-similar behavior with punctuated equilibria.
The probability density for the lifetimes of ecological communities is well
approximated by a power law with exponent near -2, and the corresponding power
spectral densities show 1/f noise (flicker noise) over several decades. The
long-lived communities (quasi-steady states) consist of a relatively small
number of mutualistically interacting species, and they are surrounded by a
``protection zone'' of closely related genotypes that have a very low
probability of invading the resident community. The extent of the protection
zone affects the stability of the community in a way analogous to the height of
the free-energy barrier surrounding a metastable state in a physical system.
Measures of biological diversity are on average stationary with no discernible
trends, even over our very long simulation runs of approximately 3.4x10^7
generations.Comment: 20 pages RevTex. Minor revisions consistent with published versio
Guiding the Way to Gamma-Ray Sources: X-ray Studies of Supernova Remnants
Supernova remnants have long been suggested as a class of potential
counterparts to unidentified gamma-ray sources. The mechanisms by which such
gamma-rays can arise may include emission from a pulsar associated with a
remnant, or a variety of processes associated with energetic particles
accelerated by the SNR shock. Imaging and spectral observations in the X-ray
band can be used to identify properties of the remnants that lead to gamma-ray
emission, including the presence of pulsar-driven nebulae, nonthermal X-ray
emission from the SNR shells, and the interaction of SNRs with dense
surrounding material.Comment: 16 pages, 11 figures, To appear in the proceedings of the workshop:
"The Nature of the Unidentified Galactic Gamma-Ray Sources" held at INAOE,
Mexico, October 2000, (A.Carraminana, O. Reiner and D. Thompson, eds.
Untargeted Metabolome Analysis of Alcohol-Exposed Pregnancies Reveals Metabolite Differences That Are Associated with Infant Birth Outcomes
Prenatal alcohol exposure can produce offspring growth deficits and is a leading cause of neurodevelopmental disability. We used untargeted metabolomics to generate mechanistic insight into how alcohol impairs fetal development. In the Western Cape Province of South Africa, 52 women between gestational weeks 5–36 (mean 18.5 ± 6.5) were recruited, and they provided a finger-prick fasting bloodspot that underwent mass spectrometry. Metabolomic data were analyzed using partial least squares-discriminant analyses (PLS-DA) to identify metabolites that correlated with alcohol exposure and infant birth outcomes. Women who consumed alcohol in the past seven days were distinguished by a metabolite profile that included reduced sphingomyelins, cholesterol, and pregnenolones, and elevated fatty acids, acyl and amino acyl carnitines, and androsterones. Using PLS-DA, 25 of the top 30 metabolites differentiating maternal groups were reduced by alcohol with medium-chain free fatty acids and oxidized sugar derivatives having the greatest influence. A separate ortho-PLS-DA analysis identified a common set of 13 metabolites that were associated with infant length, weight, and head circumference. These included monoacylglycerols, glycerol-3-phosphate, and unidentified metabolites, and most of their associations were negative, implying they represent processes having adverse consequences for fetal development
Comparing HIV case detection in prison during opt-in vs. Opt-out testing policies
Routine HIV screening in health
care settings, including prisons and jails,
is recommended by the US Centers for
Disease Control and Prevention to
enhance the detection of HIV infection
Species abundance distributions: moving beyond single prediction theories to integration within an ecological framework
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/75247/1/j.1461-0248.2007.01094.x.pd
- …