Electromechanical wavelength tuning of double-membrane photonic crystal cavities

We present a method for tuning the resonant wavelength of photonic crystal cavities (PCCs) around 1.55 um. Large tuning of the PCC mode is enabled by electromechanically controlling the separation between two parallel InGaAsP membranes. A fabrication method to avoid sticking between the membranes is discussed. Reversible red/blue shifting of the symmetric/anti-symmetric modes has been observed, which provides clear evidence of the electromechanical tuning, and a maximum shift of 10 nm with < 6 V applied bias has been obtained.Comment: 9 pages, 3 figure

Size dependent exciton g-factor in self-assembled InAs/InP quantum dots

We have studied the size dependence of the exciton g-factor in self-assembled InAs/InP quantum dots. Photoluminescence measurements on a large ensemble of these dots indicate a multimodal height distribution. Cross-sectional Scanning Tunneling Microscopy measurements have been performed and support the interpretation of the macro photoluminescence spectra. More than 160 individual quantum dots have systematically been investigated by analyzing single dot magneto-luminescence between 1200nm and 1600 nm. We demonstrate a strong dependence of the exciton g-factor on the height and diameter of the quantum dots, which eventually gives rise to a sign change of the g-factor. The observed correlation between exciton g-factor and the size of the dots is in good agreement with calculations. Moreover, we find a size dependent anisotropy splitting of the exciton emission in zero magnetic field.Comment: 15 pages, 7 figure

Presence of thiamine pyrophosphate in mammalian peroxisomes

<p>Abstract</p> <p>Background</p> <p>Thiamine pyrophosphate (TPP) is a cofactor for 2-hydroxyacyl-CoA lyase 1 (HACL1), a peroxisomal enzyme essential for the α-oxidation of phytanic acid and 2-hydroxy straight chain fatty acids. So far, HACL1 is the only known peroxisomal TPP-dependent enzyme in mammals. Little is known about the transport of metabolites and cofactors across the peroxisomal membrane and no peroxisomal thiamine or TPP carrier has been identified in mammals yet. This study was undertaken to get a better insight into these issues and to shed light on the role of TPP in peroxisomal metabolism.</p> <p>Results</p> <p>Because of the crucial role of the cofactor TPP, we reanalyzed its subcellular localization in rat liver. In addition to the known mitochondrial and cytosolic pools, we demonstrated, for the first time, that peroxisomes contain TPP (177 ± 2 pmol/mg protein). Subsequently, we verified whether TPP could be synthesized from its precursor thiamine, <it>in situ</it>, by a peroxisomal thiamine pyrophosphokinase (TPK). However, TPK activity was exclusively recovered in the cytosol.</p> <p>Conclusion</p> <p>Our results clearly indicate that mammalian peroxisomes do contain TPP but that no pyrophosphorylation of thiamine occurs in these organelles, implying that thiamine must enter the peroxisome already pyrophosphorylated. Consequently, TPP entry may depend on a specific transport system or, in a bound form, on HACL1 translocation.</p

Peroxisomal 2-Hydroxyacyl-CoA Lyase Is Involved in Endogenous Biosynthesis of Heptadecanoic Acid.

Circulating heptadecanoic acid (C17:0) is reported to be a pathology risk/prognosis biomarker and a dietary biomarker. This pathology relationship has been shown to be reliably predictive even when independent of dietary contributions, suggesting that the endogenous biosynthesis of C17:0 is related to the pathological aetiology. Little is known about C17:0 biosynthesis, which tissues contribute to the circulating levels, and how C17:0 is related to pathology. Hacl1+/- mice were mated to obtain Hacl1-/- and Hacl1+/+ control mice. At 14 weeks, they were anesthetized for tissue collection and fatty acid analysis. Compared to Hacl1+/+, C15:0 was not significantly affected in any Hacl1-/- tissues. However, the Hacl1-/- plasma and liver C17:0 levels were significantly lower: ~26% and ~22%, respectively. No significant differences were seen in the different adipose tissues. To conclude, Hacl1 plays a significant role in the liver and plasma levels of C17:0, providing evidence it can be endogenously biosynthesized via alpha-oxidation. The strong inverse association of C17:0 with pathology raises the question whether there is a direct link between α-oxidation and these diseases. Currently, there is no clear evidence, warranting further research into the role of α-oxidation in relation to metabolic diseases

Nano-optomechanical fiber-tip sensing

Nano-optomechanical sensors exploit light confinement at the nanoscale to enable very precise measurements of displacement, force, acceleration, and mass. Their application is hampered by the complex optical set-ups or packaging schemes required to couple light to and from the nano-optomechanical resonator. In this work, we present a fiber-coupled nano-optomechanical sensor that requires no coupling optics. This is achieved by directly placing a nano-optomechanical structure, a double membrane photonic crystal (DM-PhC), on the facet of a fiber, using a simple and scalable wafer-to-fiber transfer method. The device is probed in reflection and has a resonance at telecom wavelengths with a relatively broad spectral width of 3–10 nm, which is advantageous for a simple read-out and achieves a displacement imprecision of $$10\,{{\rm{fm}}}/{\sqrt{{\rm{Hz}}}}$$. Using resonant driving and a ringdown measurement, we can induce and monitor mechanical oscillations with an nm-scale amplitude via the fiber, which allows for tracking the mechanical resonant frequency and the mechanical linewidth with imprecisions of 79 and 12 Hz, respectively, at integration times of 4.5 s. We further demonstrate the application of this fiber-tip sensor to the measurement of pressure, using the effect of collisional damping on the mechanical linewidth, leading to the imprecision of $$9\times {10}^{-4}\,{\rm{mbar}}$$with an integration time of 290 s. This combination of optomechanics and fiber-tip sensing may open the way to a new generation of fiber sensors with unprecedented functionality, ultrasmall footprint, and low-cost readout

The influence of human resource practices on perceived work ability and the preferred retirement age: A latent growth modelling approach

Organisations are challenged to extend working lives of older workers. However, there is little empirical evidence available on how organisations should do this. This study aims to fill this gap by testing the effect of Human Resource (HR) practices on perceived work ability and the preferred retirement age. Based on the Conversation of Resources theory, we expected that the use of HR practices has a positive effect on perceived work ability and preferred retirement age. We have conducted latent growth curve modelling to test our hypotheses amongst 12,444 employees aged 45 and older at four time points. The results indicate that developmental practices are positively related to work ability, whereas maintenance practices are negatively related to work ability and the preferred retirement age. Accommodative practices are negatively related to the intercepts of both outcomes but not to the slopes, whereas utilisation practices are not related to the outcomes at all.publishedVersio

Glial β-Oxidation regulates drosophila energy metabolism

The brain's impotence to utilize long-chain fatty acids as fuel, one of the dogmas in neuroscience, is surprising, since the nervous system is the tissue most energy consuming and most vulnerable to a lack of energy. Challenging this view, we here show in vivo that loss of the Drosophila carnitine palmitoyltransferase 2 (CPT2), an enzyme required for mitochondrial β-oxidation of long-chain fatty acids as substrates for energy production, results in the accumulation of triacylglyceride-filled lipid droplets in adult Drosophila brain but not in obesity. CPT2 rescue in glial cells alone is sufficient to restore triacylglyceride homeostasis, and we suggest that this is mediated by the release of ketone bodies from the rescued glial cells. These results demonstrate that the adult brain is able to catabolize fatty acids for cellular energy production.This work was partially supported by the Flanders Fund for Scientific Research (FWO G 0.666.10N), NEUROBRAINNET IAP 7/16, Flemish Government Methusalem Grant, Spanish Ministry of Science (SAF2010-14906) and Innovation Ingenio-Consolider (CSD2010-00045) and Spanish Ministry of Economy and Competitiveness (SAF2013-45392).Peer Reviewe