14 research outputs found
Effects of transcutaneous electrical nerve stimulation (TENS) on arterial stiffness and blood pressure in resistant hypertensive individuals: study protocol for a randomized controlled trial
EHMTI-0264. Differences of some cytochemical parameters in persons with and without migraine
Effect of metabolic syndrome on monocyte activity in diabetics with coronary atherosclerosis
Relationship between nitric oxide production and arachidonic acid metabolism in platelet membranes of coronary artery disease patients with and without diabetes
587 VASOMOTOR DYSFUNCTION AND ALTERATIONS OF CIRCULATING CYTOKINES IN DIABETIC POLYNEUROPATHY PATIENTS WITH AND WITHOUT MECHANICAL ALLODYNIA
The continuums of impairment in vascular reactivity across the spectrum of cardiometabolic health: a systematic review and network meta-analysis
This study aimed to assess, for the first time, the change in vascular reactivity across the full spectrum of cardiometabolic health. Systematic searches were conducted in MEDLINE and EMBASE databases from their inception to March 13, 2017, including studies that assessed basal vascular reactivity in two or more of the following health groups (aged ≥18 years old): healthy, overweight, obesity, impaired glucose tolerance, metabolic syndrome, or type 2 diabetes with or without complications. Direct and indirect comparisons of vascular reactivity were combined using a network meta-analysis. Comparing data from 193 articles (7226 healthy subjects and 19344 patients), the network meta-analyses revealed a progressive impairment in vascular reactivity (flow-mediated dilation data) from the clinical onset of an overweight status (-0.41%, 95% CI, -0.98 to 0.15) through to the development of vascular complications in those with type 2 diabetes (-4.26%, 95% CI, -4.97 to -3.54). Meta-regressions revealed that for every 1 mmol/l increase in fasting blood glucose concentration, flow-mediated dilation decreased by 0.52%. Acknowledging that the time course of disease may vary between patients, this study demonstrates multiple continuums of vascular dysfunction where the severity of impairment in vascular reactivity progressively increases throughout the pathogenesis of obesity and/or insulin resistance, providing information that is important to enhancing the timing and effectiveness of strategies that aim to improve cardiovascular outcomes.Jordan Loader, Charles Khouri, Frances Taylor, Simon Stewart, Christian Lorenzen, Jean, Luc Cracowski, Guillaume Walther, Matthieu Rousti