Process for Transforming Teicoplanin Factor A2 Component 1 into Teicoplanin Factor A2 Component 3

The present invention refers to a process for transforming teicoplanin factor A2 component 1 into teicoplanin factor A2 component 3 by means of a chemical reaction which includes the catalytical hydrogenation of the substrate

Oxidation of benzylic alcohols and ethers to carbonyl derivatives by nitric acid in dichloromethane

Nitric acid in dichloromethane may be successfully employed for the oxidation of benzylic alcohols and ethers to the corresponding carbonyl compounds. The proposed method proved to be of general applicability, affording very good yields of aldehydes and ketones and showing interesting chemoselectivity in many instances, allowing competitive aromatic nitration to be avoided, as well as - in the case of aldehydes - any further oxidation to carboxylic acids. The reaction probably proceeds by a radical mechanism, the active species in the oxidation process being NO2. Competitive formation of nitro esters was observed in some cases, whereas poor results were obtained with allylic and non-benzylic substrates

Process for Transforming Teicoplanin Factor A2 Component 1 into Teicoplanin Factor A2 Component 3

The present invention refers to a process for transforming teicoplanin factor A2 component 1 into teicoplanin factor A2 component 3 by means of a chemical reaction which includes the catalytical hydrogenation of the substrate

Process for Preparing Antibiotic L 17054

The present invention is directed to a chemical process for preparing the antibiotic substance denominated antibiotic L 17054 and its pharmaceutically acceptable salts by selectively hydrolizing teicoplanin or a factor or compound thereof with a concentrated strong organic acid

Aromatic Tertiary Amines and n-Butyl Nitrite

The reaction between alkyl nitrites, particularly n-butyl nitrite, and tertiary aromatic amines under a variety of experimental conditions promptly yielded products of N-dealkylation-N-nitrosation, ring nitration, ipso-substitution and, occasionally, combinations of these processes. Aminoethers were detected as final products and intermediates on the way to N-nitrosations. Reaction pathways are suggested for some of the observed behaviours on the basis of experimental evidences whereas other alternatives are discarded

Process for Preparing Antibiotic L 17392 (Deglucoteicoplanin)

Process for preparing antibiotic L 17392 by catalytically hydrogenating a deglucoteicoplanin ester of formula (I), wherein A, B and Z represent hydrogen atoms, R represents benzyl or substituted benzyl, wherein the phenyl group is substituted with at least a substituent selected from chloro, bromo, fluoro, nitro, (C1-C3)alkyl, (C1-C3)alkoxy and the like, with the exclusion of the tri-nitro phenyl group, or acid addition salts thereof, to catalytic hydrogenolysis in the presence of a poisoned hydrogenation catalyst at a temperature from 10C to 40C and a pressure between ambient pressure and 5 atm, in an inert organic solvent preferably in the presence of a mineral acid

Process for Preparing Antibiotic L 17392 (Deglucoteicoplanin)

Process for preparing antibiotic L, 17392 by catalytically hydrogenating a deglucoteicoplanin ester of formula Formula II wherein A, B and Z represent hydrogen atoms, R represents benzyl or substituted benzyl, wherein the phenyl group is substituted with at least a substituent selected from chloro, bromo, fluoro, nitro, (C1-C3)alkyl, (C1-C3)alkoxy and the like, with the exclusion of the tri-nitro phenyl group, or acid addition salts thereof, to catalytic hydrogenolysis in the presence of a poisoned hydrogenation catalyst at a temperature from 10 DEG C. to 40 DEG C. and a pressure between ambient pressure and 5 atm, in an inert organic solvent preferably in the presence of a mineral acid

Chemical Process for Preparing Antibiotic L 17392 (Deglucoteicoplanin) and its Salts

The present invention is directed to a chemical process for preparing antibiotic L 17392 (deglucoteicoplanin) and its salts with bases and acids by submitting a teicoplanin compound or a teicoplanin-like compound to controlled strong acidic hydrolysis conditions

Chemical Process for Preparing Antibiotic L 17054

The present invention is directed to a chemical process for preparing the antibiotic substance denominated antibiotic L 17054 and its pharmaceutically acceptable salts by selectively hydrolizing teicoplanin or a factor or compound thereof with a concentrated strong organic acid

Nucleophilic Substitution in Diphenylmethyl Derivatives. I. Formolysis of Diarylmethyl Derivatives: an alpha-Substituent Effect

The reactions of formic acid with and without addition of sodium formate with diphenylmethanol (4) and chlorodiphenylmethane (3) were compared to those with hydroxydiphenylacetic (benzilic) acid (12a) and chlorodiphenylacetic acid (14a). Formic acid did not favour any S(N)1-type reaction on 4, but a strong catalysis by iodide ion was observed. Sodium formate rapidly performed the substitution of the chlorine in 3. A similar outcome was obtained with chloro acid 14a, but the rationalization of the results is different. Chloro acid 14a and its methyl ester 14b were prompt to react, but the equilibria were shifted to alpha-formyloxy products 13 only by the addition of HCOONa. HCOOH was unable to perform any reduction on either 3 and 4 or 12a and 14a, a fact which was taken as evidence for concerted substitution mechanisms on ion pairs or betaine 15. Mechanistic implications are drawn