Near Infrared Spectroscopic Monitoring During Cardiopulmonary Exercise Testing Detects Anaerobic Threshold

Cardiopulmonary exercise testing (CPET) provides assessment of the integrative responses involving the pulmonary, cardiovascular, and skeletal muscle systems. Application of exercise testing remains limited to children who are able to understand and cooperate with the exercise protocol. Near-infrared spectroscopy (NIRS) provides a noninvasive, continuous method to monitor regional tissue oxygenation (rSO2). Our specific aim was to predict anaerobic threshold (AT) during CPET noninvasively using two-site NIRS monitoring. Achievement of a practical noninvasive technology for estimating AT will increase the compatibility of CPET. Patients without structural or acquired heart disease were eligible for inclusion if they were ordered to undergo CPET by a cardiologist. Data from 51 subjects was analyzed. The ventilatory anaerobic threshold (VAT) was computed on VCO2 and respiratory quotient post hoc using the standard V-slope method. The inflection points of the regional rSO2 time-series were identified as the noninvasive regional NIRS AT for each of the two monitored regions (cerebral and kidney). AT calculation made using an average of kidney and brain NIRS matched the calculation made by VAT for the same patient. Two-site NIRS monitoring of visceral organs is a predictor of AT

Magnetic field driven enhanced ferroelectric switching in self-grown ferroelectric-ferromagnetic composite in the BiFeO3-BaTiO3 multiferroic alloy system

Over the years attempts have been made to compensate for the inherent weaknesses in the bulk state of the multiferroic BiFeO3, such as high leakage current and the absence of ferromagnetic correlation, and exploit its magnetoelectric potential by forming solid solutions with other perovskites. Studies in the recent few years have shown that alloying of BiFeO3 with BaTiO3, both with and without additives, can induce both ferroelectric and ferromagnetic switching. While the coexistence of both the ferroic orders is encouraging from the view point of technological applications, the origin of ferromagnetism in this system remains elusive. Here, we synthesized such compositions and carried out a detailed structural analysis employing magnetic separation of the powder particles. We found that the origin of ferromagnetism lies in the spontaneous precipitation of a minor ( ~ 1 wt %) barium hexaferrite (BaFe9O19) phase, often undetected in routine x-ray diffraction studies of powders sampled from the entire specimen. We also demonstrate that inspite of the insignificant fraction the ferrimagnetic phase, this self-grown composite exhibit noticeably enhanced ferroelectric switching in the presence of external magnetic field. We obtained a dc magnetoelectric coupling of ~ 9 x 10-8 s/m, a value which is comparable to what has been reported for layered ferroelectric/ferromagnetic laminates and bilayer thin film ferroelectric-ferromagnetic hetrostructures. Our study suggests that reasonably large magnetoelectric coupling is realizable in simple 0-3 ferroelectric-ferromagnetic bulk composites provided synthesis strategies are developed which induces spontaneous precipitation of the ferromagnetic phase in small volume fraction to ensure good insulating behaviour of the composite thus developed.Comment: 21 pages, 7 figure

Reachability under Contextual Locking

The pairwise reachability problem for a multi-threaded program asks, given control locations in two threads, whether they can be simultaneously reached in an execution of the program. The problem is important for static analysis and is used to detect statements that are concurrently enabled. This problem is in general undecidable even when data is abstracted and when the threads (with recursion) synchronize only using a finite set of locks. Popular programming paradigms that limit the lock usage patterns have been identified under which the pairwise reachability problem becomes decidable. In this paper, we consider a new natural programming paradigm, called contextual locking, which ties the lock usage to calling patterns in each thread: we assume that locks are released in the same context that they were acquired and that every lock acquired by a thread in a procedure call is released before the procedure returns. Our main result is that the pairwise reachability problem is polynomial-time decidable for this new programming paradigm as well. The problem becomes undecidable if the locks are reentrant; reentrant locking is a \emph{recursive locking} mechanism which allows a thread in a multi-threaded program to acquire the reentrant lock multiple times.Comment: A preliminary version appears in TACAS 201

Economics of Production of Green Peas (Pisum sativum L.) in Punjab

The economics of production and factors influencing the productivity of green peas in Punjab have been studied using the primary data from pea growers. The data have been analysed using simple tabular and functional analyses. The results have revealed that the green peas and wheat are the main crops in rabi season. It has been noticed that 75.85 per cent of the farmers purchase pea seeds from dealers. The yield of green peas has been found the highest on small farms among all the farm-size categories. The total cost incurred has been higher in large than small and medium farmers due to more use of inputs by the former. The gross and net returns have been found higher in large than small and medium farmers due to realization of higher prices by them and exploring of other markets due to their higher marketable surpluses. The functional analysis has revealed that the fertilizers, irrigation and machinery are the impact variables, influencing the productivity of green peas positively. The returns over variable costs in the case of peas have been higher by 129 per cent than those in wheat (main competing crop). It has been argued that the farmers be advised by the agricultural extension experts to adopt green pea cultivation for improving the efficiency of the farms through increased income per unit of land. Moreover, it will provide impetus to the diversification program of the state government and improve the soil health.Agricultural and Food Policy,

Near Infrared Spectroscopy Describes Physiologic Payback Associated With Excess Postexercise Oxygen Consumption in Healthy Controls and Children With Complex Congenital Heart Disease

Exercise creates a physiologic burden with recovery from such effort crucial to adaptation. Excess postexercise oxygen consumption (EPOC) refers to the body’s increased metabolic need after work. This investigation was designed to determine the role of near infrared spectroscopy (NIRS) in the description of exercise recovery in healthy controls (NL) and children with congenital heart disease (CHD). Subjects were recruited with exercise testing performed to exhaustion. Exercise time (EXT), heart rate (HR), and oxygen consumption (VO2) were measured. Four-site NIRS (brain, kidney, deltoid, and vastus lateralis) were measured during exercise and into recovery to establish trends. Fifty individuals were recruited for each group (NL = 26 boys and 24 girls; CHD = 33 boys and 17 girls). Significant differences existed between EXT, VO2, and peak HR (P \u3c 0.01). NIRS values were examined at four distinct intervals: rest, peak work, and 2 and 5 min after exercise. Significant cerebral hyperemia was seen in children with CHD post exercise when compared to normal individuals in whom redistribution patterns were directed to somatic muscles. These identified trends support an immediate compensation of organ systems to re-establish homeostasis in peripheral beds through enhanced perfusion. Noninvasive NIRS monitoring helps delineate patterns of redistribution associated with EPOC in healthy adolescents and children with CHD