Lipid profile of patients with arterial hypertension who underwent COVID-19: possibilities of drug therapy/ LEADER

Aim. To study the dynamics of the lipid profile of hypertensive patients with dyslipidemia who underwent COVID-19.Material and methods. Hypertensive patients with dyslipidemia who underwent COVID-19 [n=126; 58 men and 68 women; median age 60 (56.0; 65.5) years] examined. Patients were included into two groups: group 1 (n=64) received a single pill combination of lisinopril + amlodipine + rosuvastatin; 2 groups (n=62) continued the previous drug treatment. Clinical, demographic, office blood pressure (BP), total cholesterol (TC), low density lipoprotein cholesterol (LDL-c), high density lipoprotein cholesterol, triglycerides, C-reactive protein (CRP) levels were assessed in all patients in 3 visits within 24 weeks.Results. The groups did not differ in prior antihypertensive therapy (except for more frequent use of angiotensin II receptor blockers in group 2, p<0.05), lipid profile and blood pressure parameters at study entry. A decrease in systolic (by 9.5%) and diastolic blood pressure (by 12.1%) after 24 weeks was found in group 1 compared with 4.29% and 5.56%, respectively, in group 2 (p<0.05). A decrease in the level of total cholesterol by 14.5% and LDL-c by 31.4% after 24 weeks was found in group 1 compared with 11.2% and 9.7%, respectively, in group 2 (p<0.05). The level of CRP during the observation period decreased by 53.7% in group 1 versus 43.4% in patients of group 2 (p<0.05).Conclusion. The single pill combination of lisinopril/amlodipine/rosuvastatin in hypertensive patients with dyslipidemia who underwent COVID-19 led to an improvement in lipid profile and blood pressure control

'RadioAstron'-A telescope with a size of 300 000 km: Main parameters and first observational results

The Russian Academy of Sciences and Federal Space Agency, together with the participation of many international organizations, worked toward the launch of the RadioAstron orbiting space observatory with its onboard 10-m reflector radio telescope from the Baikonur cosmodrome on July 18, 2011. Together with some of the largest ground-based radio telescopes and a set of stations for tracking, collecting, and reducing the data obtained, this space radio telescope forms a multi-antenna ground-space radio interferometer with extremely long baselines, making it possible for the first time to study various objects in the Universe with angular resolutions a million times better than is possible with the human eye. The project is targeted at systematic studies of compact radio-emitting sources and their dynamics. Objects to be studied include supermassive black holes, accretion disks, and relativistic jets in active galactic nuclei, stellar-mass black holes, neutron stars and hypothetical quark stars, regions of formation of stars and planetary systems in our and other galaxies, interplanetary and interstellar plasma, and the gravitational field of the Earth. The results of ground-based and inflight tests of the space radio telescope carried out in both autonomous and ground-space interferometric regimes are reported. The derived characteristics are in agreement with the main requirements of the project. The astrophysical science program has begun. © 2013 Pleiades Publishing, Ltd