Growth Differentiation Factor 15 Is Associated with Platelet Reactivity in Patients with Acute Coronary Syndrome

Bleeding events in patients with acute coronary syndrome (ACS) are a risk factor for adverse outcomes, including mortality. We investigated the association of growth differentiation factor (GDF)-15, an established predictor of bleeding complications, with on-treatment platelet reactivity in ACS patients undergoing coronary stenting receiving prasugrel or ticagrelor. Platelet aggregation was measured by multiple electrode aggregometry (MEA) in response to adenosine diphosphate (ADP), arachidonic acid (AA), thrombin receptor-activating peptide (TRAP, a protease-activated receptor-1 (PAR-1) agonist), AYPGKF (a PAR-4 agonist) and collagen (COL). GDF-15 levels were measured using a commercially available assay. GDF-15 correlated inversely with MEA ADP (r = −0.202, p = 0.004), MEA AA (r = −0.139, p = 0.048) and MEA TRAP (r = −0.190, p = 0.007). After adjustment, GDF-15 was significantly associated with MEA TRAP (β = −0.150, p = 0.044), whereas no significant associations were detectable for the other agonists. Patients with low platelet reactivity in response to ADP had significantly higher GDF-15 levels (p = 0.005). In conclusion, GDF-15 is inversely associated with TRAP-inducible platelet aggregation in ACS patients treated with state-of-the-art antiplatelet therapy and significantly elevated in patients with low platelet reactivity in response to ADP

Can Volunteered Geographic Information be a participant in eEnvironment and SDI?

We investigate the potential role Volunteered Geographic Information (VGI) can play in eEvironment and various Spatial Data Infrastructures (SDI) on a local, regional, and national level. eEnvironment is the use and promotion of ICT for the purposes of environmental assessment and protection, spatial planning, and the sustainable use of natural resources. An SDI provides an institutionally sanctioned, automated means for posting, discovering, evaluating, and exchanging geospatial information by participating information producers and users. A key common theme shared by both definitions is public participation and user-centric services. We pose the research question: is VGI (an example of public participation and collaboration) is ready to participate in eEnvironment and SDI