519 research outputs found

    Predicted Properties of Microhollow Cathode Discharges in Xenon

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    A fluid model has been developed and used to help clarify the physical mechanisms occurring in microhollow cathode discharges (MHCD). Calculated current-voltage (I-V) characteristics and gas temperatures in xenon at 100 Torr are presented. Consistent with previous experimental results in similar conditions, we find a voltage maximum in the I-V characteristic. We show that this structure reflects a transition between a low-current, abnormal discharge localized inside the cylindrical hollow cathode to a higher-current, normal glow discharge sustained by electron emission from the outer surface of the cathode. This transition, due to the geometry of the device, is a factor contributing to the well-known stability of MHCDs

    Geochemical constraints on the origin of enigmatic cemented chalks, Norfolk, UK

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    Very hard cemented chalk stacks and crusts found locally in the upper part of the Cretaceous Chalk of north Norfolk, UK, are related to solution features. The solution features, mainly pipes and caves, formed after deposition of the overlying Middle Pleistocene Wroxham Crag, probably by routing of sub-glacial, or glacial, melt-waters derived from late Pleistocene glaciers. New geochemical (particularly stable isotope) data shows that cementation of the chalks, although related spatially to the solution features, was not caused by glacier-derived waters. The carbon isotope composition of the chalk cements is typically around -9.5‰, indicative of biologically active soils. Moreover, the oxygen isotope compositions of the cements, around -5‰, are incompatible with water d18O values much below -9 to -10‰ (which probably precludes isotopically negative glacier-derived water), as resulting palaeo-temperatures are below zero. Taken together, the isotope data suggest chalk cementation occurred under interglacial conditions similar to the present. Dissolved calcium carbonate for cementation came from dissolution of reworked chalk in overlying MIS 12 glacial tills

    An improved empirical model of electron and ion fluxes at geosynchronous orbit based on upstream solar wind conditions

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    A new empirical model of the electron fluxes and ion fluxes at geosynchronous orbit (GEO) is introduced, based on observations by Los Alamos National Laboratory (LANL) satellites. The model provides flux predictions in the energy range ~1 eV to ~40 keV, as a function of local time, energy, and the strength of the solar wind electric field (the negative product of the solar wind speed and the z component of the magnetic field). Given appropriate upstream solar wind measurements, the model provides a forecast of the fluxes at GEO with a ~1 h lead time. Model predictions are tested against in‐sample observations from LANL satellites and also against out‐of‐sample observations from the Compact Environmental Anomaly Sensor II detector on the AMC‐12 satellite. The model does not reproduce all structure seen in the observations. However, for the intervals studied here (quiet and storm times) the normalized root‐mean‐square deviation < ~0.3. It is intended that the model will improve forecasting of the spacecraft environment at GEO and also provide improved boundary/input conditions for physical models of the magnetosphere.Key PointsNew model of electron and ion fluxes at GEO (driven by ‐vBz) provides a ~1 h forecast of fluxes in the energy range ~1 eV to ~40 keVThe main benefit from the new model is the ability to predict the fluxes at GEO in advanceForecasts are a good match to observations during quiet times and storm timesPeer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/134149/1/swe20339_am.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/134149/2/swe20339.pd

    Hexatic-Herringbone Coupling at the Hexatic Transition in Smectic Liquid Crystals: 4-Ďľ\epsilon Renormalization Group Calculations Revisited

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    Simple symmetry considerations would suggest that the transition from the smectic-A phase to the long-range bond orientationally ordered hexatic smectic-B phase should belong to the XY universality class. However, a number of experimental studies have constantly reported over the past twenty years "novel" critical behavior with non-XY critical exponents for this transition. Bruinsma and Aeppli argued in Physical Review Letters {\bf 48}, 1625 (1982), using a 4−ϵ4-\epsilon renormalization-group calculation, that short-range molecular herringbone correlations coupled to the hexatic ordering drive this transition first order via thermal fluctuations, and that the critical behavior observed in real systems is controlled by a `nearby' tricritical point. We have revisited the model of Bruinsma and Aeppli and present here the results of our study. We have found two nontrivial strongly-coupled herringbone-hexatic fixed points apparently missed by those authors. Yet, those two new nontrivial fixed-points are unstable, and we obtain the same final conclusion as the one reached by Bruinsma and Aeppli, namely that of a fluctuation-driven first order transition. We also discuss the effect of local two-fold distortion of the bond order as a possible missing order parameter in the Hamiltonian.Comment: 1 B/W eps figure included. Submitted to Physical Review E. Contact: [email protected]

    Base-modified UDP-sugars reduce cell surface levels of P-selectin glycoprotein 1 (PSGL-1) on IL-1β-stimulated human monocytes

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    P-selectin glycoprotein ligand-1 (PSGL-1, CD162) is a cell-surface glycoprotein that is expressed, either constitutively or inducibly, on all myeloid and lymphoid cell lineages. PSGL-1 is implicated in cell–cell interactions between platelets, leukocytes and endothelial cells, and a key mediator of inflammatory cell recruitment and transmigration into tissues. Here, we have investigated the effects of the β-1,4-galactosyltransferase inhibitor 5-(5-formylthien-2-yl) UDP-Gal (5-FT UDP-Gal, compound 1) and two close derivatives on the cell surface levels of PSGL-1 on human peripheral blood mononuclear cells (hPBMCs). PSGL-1 levels were studied both under basal conditions, and upon stimulation of hPBMCs with interleukin-1β (IL-1β). Between 1 and 24 hours after IL-1β stimulation, we observed initial PSGL-1 shedding, followed by an increase in PSGL-1 levels on the cell surface, with a maximal window between IL-1β-induced and basal levels after 72 h. All three inhibitors reduce PSGL-1 levels on IL-1β-stimulated cells in a concentration-dependent manner, but show no such effect in resting cells. Compound 1 also affects the cell surface levels of adhesion molecule CD11b in IL-1β-stimulated hPBMCs, but not of glycoproteins CD14 and CCR2. This activity profile may be linked to the inhibition of global Sialyl Lewis presentation on hPBMCs by compound 1, which we have also observed. Although this mechanistic explanation remains hypothetical at present, our results show, for the first time, that small molecules can discriminate between IL-1β-induced and basal levels of cell surface PSGL-1. These findings open new avenues for intervention with PSGL-1 presentation on the cell surface of primed hPBMCs and may have implications for anti-inflammatory drug development
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