Spitzer Mid-IR Spectra of Dust Debris Around A and Late B Type Stars: Asteroid Belt Analogs and Power-Law Dust Distributions

Using the Spitzer/Infrared Spectrograph (IRS) low-resolution modules covering wavelengths from 5 to 35 μm, we observed 52 main-sequence A and late B type stars previously seen using Spitzer/Multiband Imaging Photometer (MIPS) to have excess infrared emission at 24 μm above that expected from the stellar photosphere. The mid-IR excess is confirmed in all cases but two. While prominent spectral features are not evident in any of the spectra, we observed a striking diversity in the overall shape of the spectral energy distributions. Most of the IRS excess spectra are consistent with single-temperature blackbody emission, suggestive of dust located at a single orbital radius—a narrow ring. Assuming the excess emission originates from a population of large blackbody grains, dust temperatures range from 70 to 324 K, with a median of 190 K corresponding to a distance of 10 AU. Thirteen stars however, have dust emission that follows a power-law distribution, F_ν = F 0λ^α, with exponent α ranging from 1.0 to 2.9. The warm dust in these systems must span a greater range of orbital locations—an extended disk. All of the stars have also been observed with Spitzer/MIPS at 70 μm, with 27 of the 50 excess sources detected (signal-to-noise ratio > 3). Most 70 μm fluxes are suggestive of a cooler, Kuiper Belt-like component that may be completely independent of the asteroid belt-like warm emission detected at the IRS wavelengths. Fourteen of 37 sources with blackbody-like fits are detected at 70 μm. The 13 objects with IRS excess emission fit by a power-law disk model, however, are all detected at 70 μm (four above, three on, and six below the extrapolated power law), suggesting that the mid-IR IRS emission and far-IR 70 μm emission may be related for these sources. Overall, the observed blackbody and power-law thermal profiles reveal debris distributed in a wide variety of radial structures that do not appear to be correlated with spectral type or stellar age. An additional 43 fainter A and late B type stars without 70 μm photometry were also observed with Spitzer/IRS; results are summarized in Appendix B

Gender and educational leadership in England: a comparison of secondary headteachers' views over time

In the context of gender being a barrier to accessing leadership, this paper presents a comparison of the views of men and women head teacher (principals) of secondary schools in England in the 1990s and in 2004. The same survey instrument was used on both occasions. The perceptions of the head teachers show change in some areas and no change in others. Overall, women are more likely to become head teachers and are now less likely to be categorised into pastoral roles, but in some cases women still meet prejudice from governors and others in the wider community. Women head teachers are more likely to have partners and children than in the 1990s, sharing equally or carrying most of the domestic responsibilities, whereas male colleagues are most likely to have partners who take the majority of responsibility in the home. Essentialist stereotypes about women and men as leaders still prevail, although both the women and men head teachers see themselves as adopting a traditionally ‘feminine’ style of leadership. Women head teachers are likely to see some benefits in being a woman in a role stereotypically associated with men. However, there has been an increase in the proportion of women who feel that they have to prove their worth as a leader, and this may be linked with increased levels of accountability in schools

Women’s Long-Term Reactions to Whole-Body Scanning: A Mixed Methods Approach

This study investigated long-term impacts of whole-body scanning. A total of 91 women completed a retrospective online questionnaire. Quantitative data revealed that 31 (34%) reported greater body dissatisfaction since the scan, and only 6 (7%) reported increased satisfaction. Positive change in satisfaction was predicted by current body satisfaction but not by body mass index (BMI) at time of scanning or by age. BMI did not predict satisfaction with the scanner process or likelihood of being rescanned, though a longer gap between scanning and questionnaire completion predicted satisfaction with the process. Inductive thematic analysis of responses to an open-ended question suggested that although women were comfortable being scanned and wanted to see an accurate and objective view of their size and shape, they also felt threatened and vulnerable when seeing their bodies on the printed output. It is concluded that whole-body scanning should be used with caution, particularly with women with existing body concerns

Clinical and Genotype Characteristics and Symptom Migration in Patients With Mixed Phenotype Transthyretin Amyloidosis from the Transthyretin Amyloidosis Outcomes Survey

Introduction: Transthyretin amyloidosis (ATTR amyloidosis) is primarily associated with a cardiac or neurologic phenotype, but a mixed phenotype is increasingly described. Methods: This study describes the mixed phenotype cohort in the Transthyretin Amyloidosis Outcomes Survey (THAOS). THAOS is an ongoing, longitudinal, observational survey of patients with ATTR amyloidosis, including both hereditary (ATTRv) and wild-type disease, and asymptomatic carriers of pathogenic transthyretin variants. Baseline characteristics of patients with a mixed phenotype (at enrollment or reclassified during follow-up) are described (data cutoff: January 4, 2022). Results: Approximately one-third of symptomatic patients (n = 1185/3542; 33.5%) were classified at enrollment or follow-up as mixed phenotype (median age, 66.5 years). Of those, 344 (29.0%) were reclassified to mixed phenotype within a median 1–2 years of follow-up. Most patients with mixed phenotype had ATTRv amyloidosis (75.7%). The most frequent genotypes were V30M (38.9%) and wild type (24.3%). Conclusions: These THAOS data represent the largest analysis of a real-world mixed phenotype ATTR amyloidosis population to date and suggest that a mixed phenotype may be more prevalent than previously thought. Patients may also migrate from a primarily neurologic or cardiologic presentation to a mixed phenotype over time. These data reinforce the need for multidisciplinary evaluation at initial assessment and follow-up of all patients with ATTR amyloidosis. Trial Registration: ClinicalTrials.gov: NCT00628745

Lignin-derived electrospun freestanding carbons as alternative electrodes for redox flow batteries

Based on information provided the embargo period/end date is 12 monthsBased on information provided the embargo period/end date is 12 month

Thoracic Operations for Pulmonary Nodules Are Frequently Not Futile in Patients with Benign Disease

IntroductionPulmonary nodules often require operative resection to obtain a diagnosis. However, 10 to 30% of operations result in a benign diagnosis. Our purpose was to determine whether negative thoracic operations are futile by describing the pathological diagnoses; determining new diagnoses and treatment changes initiated based on operative findings; and assessing morbidity, mortality, and cost of the procedure.MethodsAt our academic medical center, 278 thoracic operations were performed for known or suspected cancer between January 1, 2005, and April 1, 2009. We collected and summarized data pertaining to preoperative patient and nodule characteristics, pathologic diagnosis, postoperative treatment changes resulting from surgical resection, perioperative morbidity and mortality, and hospital charges for patients with benign pathology.ResultsTwenty-three percent (65/278) of patients who underwent surgical resection for a suspicious nodule had benign pathology. We report granulomatous disease in 57%, benign tumors in 15%, fibrosis in 12%, and autoimmune and vascular diseases in 9%. Definitive diagnosis or treatment changes occurred in 85% of cases. Surgical intervention led to a new diagnosis in 69%, treatment course changes in 68% of benign cases, medication changes in 38%, new consultation in 31%, definitive treatment in 9%, and underlying disease management in 34%. There was no intraoperative, in-hospital, or 30-day mortality. Postoperative in-hospital events occurred in seven patients. The mean total cost was $25,515 with a mean cost per day of$7618.ConclusionsPatients with a benign diagnosis after surgical resection for a pulmonary nodule received a new diagnosis or had a treatment course change in 85% of the cases

The left superior temporal gyrus is a shared substrate for auditory short-term memory and speech comprehension: evidence from 210 patients with stroke

Competing theories of short-term memory function make specific predictions about the functional anatomy of auditory short-term memory and its role in language comprehension. We analysed high-resolution structural magnetic resonance images from 210 stroke patients and employed a novel voxel based analysis to test the relationship between auditory short-term memory and speech comprehension. Using digit span as an index of auditory short-term memory capacity we found that the structural integrity of a posterior region of the superior temporal gyrus and sulcus predicted auditory short-term memory capacity, even when performance on a range of other measures was factored out. We show that the integrity of this region also predicts the ability to comprehend spoken sentences. Our results therefore support cognitive models that posit a shared substrate between auditory short-term memory capacity and speech comprehension ability. The method applied here will be particularly useful for modelling structure–function relationships within other complex cognitive domains

Popular attitudes to memory, the body, and social identity : the rise of external commemoration in Britain, Ireland, and New England

A comparative analysis of samples of external memorials from burial grounds in Britain, Ireland and New England reveals a widespread pattern of change in monument style and content, and exponential growth in the number of permanent memorials from the 18th century onwards. Although manifested in regionally distinctive styles on which most academic attention has so far been directed, the expansion reflects global changes in social relationships and concepts of memory and the body. An archaeological perspective reveals the importance of external memorials in articulating these changing attitudes in a world of increasing material consumption

Levodopa does not affect expression of reinforcement learning in older adults

Dopamine has been implicated in learning from rewards and punishment, and in the expression of this learning. However, many studies do not fully separate retrieval and decision mechanisms from learning and consolidation. Here, we investigated the effects of levodopa (dopamine precursor) on choice performance (isolated from learning or consolidation). We gave 31 healthy older adults 150 mg of levodopa or placebo (double-blinded, randomised) 1 hour before testing them on stimuli they had learned the value of the previous day. We found that levodopa did not affect the overall accuracy of choices, nor the relative expression of positively or negatively reinforced values. This contradicts several studies and suggests that overall dopamine levels may not play a role in the choice performance for values learned through reinforcement learning in older adults