15 research outputs found
Localization elements and zip codes in the intracellular transport and localization of messenger RNAs in Saccharomyces cerevisiae
In vivo imaging and tracking of host–microbiota interactions via metabolic labeling of gut anaerobic bacteria
Proximity-CLIP provides a snapshot of protein-occupied RNA elements in subcellular compartments
Towards a complete map of the human long non-coding RNA transcriptome.
Gene maps, or annotations, enable us to navigate the functional landscape of our genome. They are a resource upon which virtually all studies depend, from single-gene to genome-wide scales and from basic molecular biology to medical genetics. Yet present-day annotations suffer from trade-offs between quality and size, with serious but often unappreciated consequences for downstream studies. This is particularly true for long non-coding RNAs (lncRNAs), which are poorly characterized compared to protein-coding genes. Long-read sequencing technologies promise to improve current annotations, paving the way towards a complete annotation of lncRNAs expressed throughout a human lifetime