A Partial Allocation Local Search Matheuristic for Solving the School Bus Routing Problem with Bus Stop Selection

This paper addresses the school bus routing problem with bus stop selection, which jointly handles the problems of determining the set of bus stops to visit, allocating each student to one of these bus stops and computing the routes that visit the selected bus stops, so that the total routing cost is minimized and the walking distance of the students is limited by a given value. A fast and efficient matheuristic is developed based on an innovative approach that first partially allocates the students to a set of active stops that they can reach, and computes a set of routes that minimizes the routing cost. Then, a refining process is performed to complete the allocation and to adapt the routes until a feasible solution is obtained. The algorithm is tested on a set of benchmark instances. The computational results show the efficiency of the algorithm in terms of the quality of the solutions yielded and the computing time

The lattice of Fitting classes which are right extensible by soluble groups

In this paper we study the set of Fitting classes which are right extensible by soluble groups ordered by the inclusion relation. The consideration of the associated lattices gives rise to new Fitting classes and it allows to obtain some injectivity criteria for general Fitting classes

Effects of cooking over the stability of fatty acids as bioactive compounds in enriched pasta with a fish by-product

Background and objectives: Fusilli pasta enriched with sea bass concentrate (Dicentrarchus labrax) was developed with the aim of increasing its content in proteins and especially in polyunsaturated fatty acids (PUFA) like Omega-3. Pasta made from two types of cereals (wheat and spelt) and fish by-product with or without a natural antioxidant were cooking prior to consumption, and nutritional and physicochemical characteristics were evaluated. Findings: Enriched developed pasta showed high levels of protein, fat, and fiber, and the fatty acid profiles confirmed a substantial enrichment in bioactive compounds (omega-3 fatty acids). The cooking of pasta before consumption was able to reduce bacterial loads guaranteeing food safety and improving nutritional availability. Furthermore, an increase in the MUFA and PUFA content was revealed, which could represent an advantage to offer a better source of functional ingredients (EPA & DHA). Conclusions: The combination of heat from cooking with formulations containing antioxidants seems to offer a remarkable synergistic effect to preserve unsaturated fatty acids with desirable nutritional properties. Significance and novelty: Pasta enriched with bioactive compounds from fish by-product after cooking treatment before consumption appears to be an effectiveness option to improve healthy human nutrition

Archaeological prospection with corona and wv-3 satellite imagery of the archaeological site of zar tepe (uzbekistan)

Abstract. The use of different data from satellite platforms for archaeological prospecting and remote sensing has been applied since the end of the 20th century. Although the current use of drones with different visible and multispectral sensors for small areas has partially replaced in some cases the use of this type of satellite information due to its higher spatial resolution. The historical importance of satellite imagery is essential to find out about and compare the transformations of the archaeological landscape of the last 60 years since the CORONA satellite program started in 1960. In this paper we propose the evaluation of a proposal for the automation of processes of two photographic reconnaissance correlative satellite programs CORONA (1960-1972), HEXAGON (1971-1986) declassified since 1995 and 2011 respectively, and the commercial satellite WorldView-3 (WV3) (2014) for use in the detection of buried archaeological structures at the archaeological site of Zar Tepe in the southeast of Uzbekistan. This is a site located in the Surkhan Darya region very little known between the first century BC and the fourth century AD. This methodology is part of the IPAEB project (International Pluridisciplinary Archaeological Expedition to Bactria) led by the University of Barcelona, the University of Salamanca and recently in 2019 the University of Zaragoza. IPAEB was started in 2006 in the South of Uzbekistan and is currently trying to explore the urban planning of the Zar Tepe archaeological site and the elements that make up its natural physical environment: evidence of communication routes, smallholdings, irrigation channels, fences and sources of raw materials

As-built 3D heritage city modelling to support numerical structural analysis: application to the assessment of an archaeological remain

Terrestrial laser scanning is a widely used technology to digitise archaeological, architectural and cultural heritage. This allows for modelling the assets’ real condition in comparison with traditional data acquisition methods. This paper, based on the case study of the basilica in the Baelo Claudia archaeological ensemble (Tarifa, Spain), justifies the need of accurate heritage modelling against excessively simplified approaches in order to support structural safety analysis. To do this, after validating the 3D meshing process from point cloud data, the semi-automatic digital reconstitution of the basilica columns is performed. Next, a geometric analysis is conducted to calculate the structural alterations of the columns. In order to determine the structural performance, focusing both on the accuracy and suitability of the geometric models, static and modal analyses are carried out by means of the finite element method (FEM) on three different models for the most unfavourable column in terms of structural damage: (1) as-built (2) simplified and (3) ideal model without deformations. Finally, the outcomes show that the as-built modelling enhances the conservation status analysis of the 3D heritage city (in terms of realistic compliance factor values), although further automation still needs to be implemented in the modelling process

Hydrogen as energy storage for wind energy

Nowadays, problems associated with greenhouse gases emission and fuel ending, makes that renewable energy sources and hydrogen technology have high interest for governments and researchers, and become an option for an environmentaly sustainable world. Renewable energy sources, like solar energy and wind energy, have been used for the last three decades to produce electricity. Researchers and companies have improved the efficiency of this kind of systems, but they have a problem due to energy source temporality that does a fluctuation in systems power output. This fluctuation makes sometimes energy demand is higher than energy produced by the system and vice versa. Hydrogen Technology, actuating as energy storage, may solve this problem. In this paper, a wind-hydrogen installation will be described. Also, its behavior in relation to different electric demand will be analysed

How the other half lives: CRISPR-Cas's influence on bacteriophages

CRISPR-Cas is a genetic adaptive immune system unique to prokaryotic cells used to combat phage and plasmid threats. The host cell adapts by incorporating DNA sequences from invading phages or plasmids into its CRISPR locus as spacers. These spacers are expressed as mobile surveillance RNAs that direct CRISPR-associated (Cas) proteins to protect against subsequent attack by the same phages or plasmids. The threat from mobile genetic elements inevitably shapes the CRISPR loci of archaea and bacteria, and simultaneously the CRISPR-Cas immune system drives evolution of these invaders. Here we highlight our recent work, as well as that of others, that seeks to understand phage mechanisms of CRISPR-Cas evasion and conditions for population coexistence of phages with CRISPR-protected prokaryotes.Comment: 24 pages, 8 figure

Fisetin protects against cardiac cell death through reduction of ROS production and caspases activity

Myocardial infarction (MI) is a leading cause of death worldwide. Reperfusion is considered as an optimal therapy following cardiac ischemia. However, the promotion of a rapid elevation of O2 levels in ischemic cells produces high amounts of reactive oxygen species (ROS) leading to myocardial tissue injury. This phenomenon is called ischemia reperfusion injury (IRI). We aimed at identifying new and effective compounds to treat MI and minimize IRI. We previously studied heart regeneration following myocardial injury in zebrafish and described each step of the regeneration process, from the day of injury until complete recovery, in terms of transcriptional responses. Here, we mined the data and performed a deep in silico analysis to identify drugs highly likely to induce cardiac regeneration. Fisetin was identified as the top candidate. We validated its effects in an in vitro model of MI/IRI in mammalian cardiac cells. Fisetin enhances viability of rat cardiomyocytes following hypoxia/starvation - reoxygenation. It inhibits apoptosis, decreases ROS generation and caspase activation and protects from DNA damage. Interestingly, fisetin also activates genes involved in cell proliferation. Fisetin is thus a highly promising candidate drug with clinical potential to protect from ischemic damage following MI and to overcome IRI.This work was supported by FNR, the Luxembourg National Research Fund, FNR-CORE INFUSED project. At the NorLux Laboratory and the Proteome and Genome Research Unit of LIH, it was also supported by funding from Luxembourg’s Ministry of Higher Education and Research (MESR).S